| Project/Area Number |
25460696
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IEKO Masahiro 北海道医療大学, 歯学部, 教授 (50250436)
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| Research Collaborator |
HIRANAKA Natsumi
KUMAGAI kyoko
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肥満症 / 第VII因子活性化プロテアーゼ / 第VII因子 / 脂肪細胞 / 病態マーカー |
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| Outline of Final Research Achievements |
In this research, we investigated the role of factor seven activating protease in the obesity-related organs and metabolic disorders. We obtained several findings such as gene expression of factor seven activating protease in skeletal muscle cells. During the research period, we discovered a novel finding that adipocytes secrete coagulation factor seven, which is one of substrates of factor seven activating protease. Moreover, the secretion is enhanced by two independent factors, tumor necrosis factor-alpha and isoproterenol. The factors are implicated as mediators of tissue inflammation and sympathetic activation, both of which are involved in the pathogenesis of obesity. These results suggest that factor seven derived from adipocytes could be a clinical biomarker for the pathogenesis of obesity.
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