| Project/Area Number |
25460716
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
JU YOUNG-JIN 東京医科歯科大学, 医学部附属病院, 非常勤講師 (10436636)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJI KUNIKAZU 東京医科歯科大学, 医歯学総合研究科, 准教授 (20323694)
MUNETA TAKESHI 東京医科歯科大学, 医歯学総合研究科, 教授 (50190864)
TSUJI KUNIKAZU 東京医科歯科大学, 再生医療研究センター, 教授 (10345291)
AKAZAWA CHIHIRO 東京医科歯科大学, 保健衛生学研究科, 教授 (80291160)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 変形性膝関節症 / 疼痛 / Osteoarthritis / Synovitis / Pain / Mesenchymal Stem Cells / Osteopontin / Cytokine / 関節疼痛 / 前十字靭帯再建術 / 炎症性サイトカイン / オステオポンチン / マクロファージ / CD105 / 関節液 / 炎症 |
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| Outline of Final Research Achievements |
This study was aimed to analyze the molecular mechanisms of joint pain associated with knee osteoarthritis. In this study we reported that intra-articular injection of mesenchymal stem cells isolated from syonovial membrane in the knee joint had chondroprotective and anti-inflammatory effects in monoiodoacetic acid (MIA)-induced osteoarthritis model in rats. In addition, we reported that joint pain induced by the intra-articular injection of MIA was significantly alleviated by the intra-articular injection of mesenchymal stem cells. This effect was observed only when we injected mesenchymal stem cells in the acute phase (within 1 to 5 days) of joint inflammation induced by MIA injection. These data suggest that mesenchymal stem cells might have some inhibitory effects on the pro-inflammatory mediators functioning in the immediate early stage after joint injury.
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