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Epidemiological study on the genetic polymorphisms and methylation effects of physical activity for lifestyle disease prevention

Research Project

Project/Area Number 25460759
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionSaga University

Principal Investigator

Hara Megumi  佐賀大学, 医学部, 准教授 (90336115)

Co-Investigator(Kenkyū-buntansha) 田中 恵太郎  佐賀大学, 医学部, 教授 (50217022)
西田 裕一郎  佐賀大学, 医学部, 講師 (50530185)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords遺伝子損傷 / 身体活動 / メチル化 / 遺伝子修復酵素 / がん / 身体活動量 / 遺伝子多型
Outline of Final Research Achievements

Genetic damage due to reactive oxygen species increases with age and contributes to the onset of cancer. In this study, we examined the relationship between physical activity and DNA damage, and DNA damage repair gene methylation. The concentration of urinary 8-hydroxdeoxyguanosine (8-OHdG), a DNA damage marker, was negatively correlated with the total body activity level in females and negatively correlated with mid- to high-intensity physical activity levels in males. On the other hand, DNA methylation in the promoter region of 8-oxoguanine DNA glycosylase 1 (hOGG1), a gene damage repair enzyme, was positively correlated with the amount of physical activity. Higher amount of physical activity increases endogenous antioxidant capacity and DNA damage decreases. Conversely, DNA damage increases when the amount of physical activity is low, so the promoter region of DNA is low in order to express hOGG1 Suggesting the possibility of methylation.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 2014 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (3 results) Remarks (5 results)

  • [Journal Article] Intensity-specific effect of physical activity on urinary levels of 8-hydroxydeoxyguanosine in middle-aged Japanese2016

    • Author(s)
      Hara M, Nishida Y, Shimanoe C, et. al.
    • Journal Title

      Cancer Science

      Volume: 107 Issue: 11 Pages: 1653-1659

    • DOI

      10.1111/cas.13070

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Factors Associated With Non-participation in a Face-to-Face Second Survey Conducted 5 Years After the Baseline Survey2015

    • Author(s)
      Hara M, Shimanoe C, Otsuka Y, Nishida Y, Nanri H, Horita M, Yasukata J, Miyoshi N, Yamada Y, Higaki Y, Tanaka K.
    • Journal Title

      Journal of Epidemiology

      Volume: 25 Issue: 2 Pages: 117-125

    • DOI

      10.2188/jea.JE20140116

    • NAID

      130004704585

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Associations Between <i>hOGG1</i> Ser326Cys Polymorphism and Increased Body Mass Index and Fasting Glucose Level in the Japanese General Population2014

    • Author(s)
      Hara M, Nakamura K, Nanri H, Nishida Y, Hishida A, Kawai S, Hamajima N, Kita K, Suzuki S, Mantjoro E M, Ohnaka K, Uemura H, Matsui D, Oze I, Mikami H, Kubo M and Tanaka H on behalf of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group.
    • Journal Title

      Journal of Epidemiology

      Volume: 24 Issue: 5 Pages: 379-384

    • DOI

      10.2188/jea.JE20140002

    • NAID

      130004449419

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose in the Japanese general population.2014

    • Author(s)
      Hara M, Nakamura K, Nanri H, Nishida Y, Hishida A, Kawai S, Hamajima N, Kita K, Suzuki S, Mantjoro E M, Ohnaka K, Uemura H, Matsui D, Oze I, Mikami H, Kubo M and Tanaka H
    • Journal Title

      J Epidemiol

      Volume: 未定

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Objectively measured physical activity and inflammatory cytokine levels in middle-aged Japanese people2014

    • Author(s)
      Nishida Y, Higaki Y, Taguchi N, Hara M, Nakamura K, Nanri H, Imizumi T, Sakamoto T, Horita M, Shinchi K, Tanaka K
    • Journal Title

      Preventive Medicine

      Volume: 未定

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gender-specific associations of perceived stress and coping strategies with C-reactive protein in middle-aged and older men and women2014

    • Author(s)
      Shimanoe C, Otsuka Y, Hara M, Nanri H, Nishida Y, Nakamura K, Higaki Y, Imaizumi T, Taguchi N, Sakamoto T, Horita M, Shinchi K, Tanaka K
    • Journal Title

      International Journal of Behavioral Medicine

      Volume: 未定 Issue: 5 Pages: 821-832

    • DOI

      10.1007/s12529-013-9341-y

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ミトコンドリアハプログループDが身体活動量と尿中8OHdG濃度の関連に及ぼす影響2017

    • Author(s)
      原めぐみ、西田裕一郎、福典之、田口尚人、島ノ江千里、堀田美加子、河井一明、李 云善、葛西順、葛西宏、檜垣靖樹、田中恵太郎
    • Organizer
      第27回日本疫学会学術総会
    • Place of Presentation
      甲府
    • Year and Date
      2017-01-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 加齢とhOGG1遺伝子プロモーター領域のメチル化の関連2016

    • Author(s)
      原 めぐみ、西田 裕一郎、島ノ江 千里、堀田 美加子、田中 恵太郎
    • Organizer
      第26回日本疫学会学術総会
    • Place of Presentation
      米子
    • Year and Date
      2016-01-21
    • Related Report
      2015 Research-status Report
  • [Presentation] Association between moderate/vigorous intensity of physical activity and urinary levels of 8-hydroxydeoxyguanosine2015

    • Author(s)
      Megumi Hara, Yuichiro Nishida, Chisato Shimanoe, Yasuko Otsuka, Hinako Nanri, Yasuki Higaki, Mikako Horita, Kazuaki Kawai, Yun-Shan Li, Jun Kasai, Hiroshi Kasai, Keitaro Tanaka
    • Organizer
      The 25th Annual Scientific Meeting of the Japan Epidemiological Association
    • Place of Presentation
      Nagoya
    • Year and Date
      2015-01-22 – 2015-01-23
    • Related Report
      2014 Research-status Report
  • [Remarks] 佐賀大学医学部社会医学講座予防医学分野

    • URL

      http://www.prevent.med.saga-u.ac.jp/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 佐賀大学医学部社会医学講座予防医学分野 研究業績

    • URL

      http://www.prevent.med.saga-u.ac.jp/gyoseki.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 佐賀大学医学部社会医学講座予防医学分野 業績

    • URL

      http://www.prevent.med.saga-u.ac.jp/lecture.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 佐賀大学医学部社会医学講座予防医学分野 原めぐみ

    • URL

      http://www.prevent.med.saga-u.ac.jp/hara.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 佐賀大学医学部社会医学講座予防医学分野

    • URL

      http://www.prevent.med.saga-u.ac.jp/index.html

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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