Evaluation of the influence of yellow sand dust on aggravation of allergies

• Project/Area Number: 25460793
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Kanazawa University
• Principal Investigator: Higashi Tomomi 金沢大学, 医学系, 助教 (20293342)
• Co-Investigator(Kenkyū-buntansha): 中村 裕之 金沢大学, 医学系, 教授 (30231476) ; 福冨 友馬 独立行政法人国立病院機構(相模原病院臨床研究センター), 診断・治療薬開発研究室, 室長 (30463110) ; 藤村 政樹 金沢大学, 医学系, 協力研究員 (90190066) ; 西條 清史 金沢大学, 医学系, 教授 (00178469)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 黄砂 / 慢性咳嗽 / 鼻アレルギー / 臨床疫学 / PM2.5 / 環境要因 / 喘息 / 咳喘息 / アトピー咳嗽 / アレルギー / 花粉症 / 疫学

Outline of Final Research Achievements

In this study, we investigated the relationship between atmospheric pollutant chemicals such as yellow sand dust and PM 2.5 in the environment and the allergic symptoms aggravation in recently increasing allergic diseases. Daily symptoms of patients were investigated by using an allergy diary and statistical analysis was made on relationships with yellow sand dust and other environmental substance concentrations every day.
As a result, it is reported for the first time in Japan and overseas that allergic symptoms such as cough and itchy eyes appear in patients with allergic diseases, even in low-density yellow sand dust which is not judged as Kosa day, aggravating as the concentration of yellow sand increases did. In addition, the concentrations of PM 2.5, PAHs, NO 2, SO 2, metals, etc. were also found to be associated with allergic symptoms worsening.

Research Products

• [Journal Article] 大気環境中物質とアレルギー症状の関係 (2017)
  • Author(s): 東 朋美
  • Journal Title: アレルギーの臨床 Volume: 37 Pages: 74-78
  • Peer Reviewed
• [Journal Article] Genistein and menaquinone-4 treatment-induced alterations in the expression of mRNAs and their products are beneficial to osteoblastic MC3T3-El cell functions (2017)
  • Author(s): Katsuyama M, Demura M, Katsuyama H, Tanii H, Saijoh K
  • Journal Title: Molecular Medicine Reports Volume: 16 Pages: 873-880
  • Peer Reviewed / Open Access
• [Journal Article] Association between posttraumatic stress disorder (PTSD) severity and ego structure of the Nanai people (2017)
  • Author(s): Ota Y, Korshunova N, Demura M, Katsuyama M, Katsuyama H, Rahayu SR, Saijoh K
  • Journal Title: Environ Health Prev Med Volume: 22 Pages: 59-59
• [Journal Article] Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study. (2016)
  • Author(s): Anyenda EO, Higashi T, Kambayashi Y, Nguyen TT, Michigami Y, Fujimura M, Hara J, Tsujiguchi H, Kitaoka M, Asakura H, Hori D, Yamada Y, Hayashi K, Hayakawa K, Nakamura H
  • Journal Title: Int J Environ Res Public Health Volume: 13(8) Issue: 8 Pages: 800-805
  • DOI: 10.3390/ijerph13080800
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Exposure to daily ambient particulate polycyclic aromatic hydrocarbons and cough occurrence in adult chronic cough patients (2016)
  • Author(s): Anyenda EO, Higashi T, Kambayashi Y, Nguyen TTT, Michigan Y, et al.
  • Journal Title: Atmos Environ Volume: 140 Pages: 34-41
  • DOI: 10.1016/j.atmosenv.2016.05.042
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 黄砂やPM2.5とアレルギー (2016)
  • Author(s): 東 朋美
  • Journal Title: アレルギーの臨床 Volume: 36 Pages: 72-76
  • Peer Reviewed
• [Journal Article] 大気環境中物質とアレルギーの関係 (2016)
  • Author(s): 東 朋美
  • Journal Title: アレルギーの臨床 Volume: 36 Pages: 1392-1396
  • Peer Reviewed
• [Journal Article] A Longitudinal Study of Association between Heavy Metals and Itchy Eyes, Coughing in Chronic Cough Patients: Related with Non-Immunoglobulin E Mediated Mechanism (2016)
  • Author(s): Thao Thi Thu Nguyen , Tomomi Higashi , Yasuhiro Kambayashi , Enoch Olando Anyenda , Yoshimasa Michigami , Johsuke Hara , Masaki Fujimura , Hiromasa Tsujiguchi , Masami Kitaoka , Hiroki Asakura , Daisuke Hori , Yuri Hibino, Tadashi Konoshita and Hiroyuki Nakamura
  • Journal Title: Int. J. Environ. Res. Public Health Volume: 13 Issue: 1 Pages: 110-123
  • DOI: 10.3390/ijerph13010110
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of the toxicity of a Kosa (Asian duststorm) event from view of food poisoning: observation of Kosa cloud behavior and real-time PCR analyses of Kosa bioaerosols during May 2011 in Kanazawa, Japan (2015)
  • Author(s): 2.Kobayashi F, Iwata K, Maki T, Kakikawa M, Higashi T, Yamada M, Ichinose T, Iwasaka Y
  • Journal Title: Air Quality, Atmosphere and health Volume: in press Issue: 1 Pages: 3-14
  • DOI: 10.1007/s11869-015-0333-8
  • Peer Reviewed / Open Access
• [Journal Article] Factors associated with tuberculosis cases in Semarang District, Indonesia: case–control study performed in the area where case detection rate was extremely low. (2015)
  • Author(s): Sri Ratna Rahayu, Hironobu Katsuyama, Masashi Demura, Midori Katsuyama, Yoko Ota, Hideji Tanii, Tomomi Higashi, Ngakan Putu Djaja Semadi, Kiyofumi Saijoh.
  • Journal Title: Environ Health Prev Med Volume: 20 Issue: 4 Pages: 253-261
  • DOI: 10.1007/s12199-015-0443-9
  • NAID: 50009646081
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 長引く咳への黄砂やPM2.5の影響 (2015)
  • Author(s): 東 朋美
  • Journal Title: アレルギーの臨床 Volume: 35 Pages: 61-65
  • Peer Reviewed
• [Journal Article] Exacerbation of daily cough and allergic symptpms in adult patients with chronic cough by Asian dust: A hospital-based study in Kanazawa (2014)
  • Author(s): Higashi T, Kambayashi Y, Ohkura N, Fujimura M, Nakanishi S, Yoshizaki T, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Hitomi Y, and Nakamura H
  • Journal Title: Atmospheric Environment Volume: in press Pages: 537-543
  • DOI: 10.1016/j.atmosenv.2014.01.041
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Asian dust on daily cough occurrence in patients with chronic cough: A panel study. (2014)
  • Author(s): Higashi T, Kambayashi Y, Ohkura N, Fujimura M, Nakai S, Honda Y, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Anyenda EO, Hitomi Y, Nakamura H.
  • Journal Title: Atmospheric Environment Volume: 92 Pages: 506-513
  • DOI: 10.1016/j.atmosenv.2014.04.034
  • NAID: 120005463354
  • Peer Reviewed / Open Access
• [Journal Article] 黄砂とアレルギー疾患 (2014)
  • Author(s): 東 朋美、神林康弘、藤村政樹、大倉徳幸、吉崎智一、中西清香、西條清史、早川和一、小林史尚、道上義正、人見嘉哲、中村裕之
  • Journal Title: エアロゾル研究 Volume: 29 Pages: 212-217
  • NAID: 130003393430
  • Peer Reviewed / Open Access
• [Journal Article] Exacerbation of daily cough and allergic symptoms in adult patients with chronic cough by Asian Dust: A hospital-based study in Kanazawa. (2014)
  • Author(s): Tomomi Higashi, Yasuhiro Kambayashi, Noriyuki Ohkura, Masaki Fujimura, Sayaka Nakanishi, Tomokazu Yoshizaki, Kiyofumi Saijoh, Kazuichi Hayakawa, Fumihisa Kobayashi, Yoshimasa Michigami, Yoshiaki Hitomi, Hiroyuki Nakamura.
  • Journal Title: Atmospheric Environment Volume: 印刷中
  • NAID: 120005418493
  • Peer Reviewed
• [Journal Article] Asian dust (Kosa) in allergic diseases. (2014)
  • Author(s): Higashi T, Kambayashi Y, Fujimura M, Ohkura N, Yoshizaki T, Nakanishi S, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Hitomi Y, Nakamura H.
  • Journal Title: Earozoru Kenkyu (in Japanese), Volume: 29 (S1) Pages: 212-217
  • NAID: 40020005750
  • Peer Reviewed
• [Journal Article] Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy (2013)
  • Author(s): Kitano A
  • Journal Title: PLoS One Volume: 8 Issue: 2 Pages: 15-15
  • DOI: 10.1371/journal.pone.0055289
  • URL: http://www.kanazawa-u.ac.jp/~ganken/shuyoseigyo/
  • Peer Reviewed
• [Presentation] 慢性咳嗽患者、気管支喘息患者の咳症状への黄砂とPM2.5の影響 (2017)
  • Author(s): 原丈介，〇東 朋美，山村健太，大倉徳幸，阿保未来，上野貴雄，吉崎智一，西條淸史，笠原寿郎
  • Organizer: 第48回日本職業・環境アレルギー学会
• [Presentation] 黄砂によるスギ花粉症患者の症状への影響 (2017)
  • Author(s): 上野貴雄、東朋美、原丈介、笠原寿郎、西條清史、吉崎智一
  • Organizer: 第48回日本職業・環境アレルギー学会
• [Presentation] miRNA-mediated crosstalk between Wnt3a and TGFP3 in osteoblast differentiation (2017)
  • Author(s): Shigeko Fushimi, Tsutomu Nohno, Shin-ichiro Nishimatsu, Naoki Katase, Kumiko, Terada, Midori Katsuyama, Masashi Demura, Kiyofumi Saijoh, Hitoshi Nagatsuka, Hironobu Katsuyama
  • Organizer: EXPERIMENTAL BIOLOGY
  • Int'l Joint Research
• [Presentation] 黄砂はアレルギー性気道疾患の臨床症状を修飾するかvol.3 ～慢性咳嗽患者の咳症状への黄砂やPM2.5の影響～ (2015)
  • Author(s): 東 朋美
  • Organizer: 第42回北陸アレルギー研究会
  • Place of Presentation: 金沢都ホテル(石川県）
  • Year and Date: 2015-12-05
• [Presentation] 黄砂を含む環境中化学物質の呼吸器疾患への影響 (2015)
  • Author(s): 中村裕之、東 朋美
  • Organizer: 第25回日本産業衛生学会 産業医・産業看護全国協議会 シンポジウム「PM2.5の環境問題の現状と今後」
  • Place of Presentation: 周南市文化会館（山口県）
  • Year and Date: 2015-09-16
  • Invited
• [Presentation] Clinical Epidemiological Study about Asian dust(kosa) effect on chronic cough patients (2015)
  • Author(s): Tomomi Higashi, Hiroyuki Nakamura, Masaki Fujimura, Johsuke Hara, Yasuhiro Kambayashi, Anyenda Enoch Olando, Takayoshi Ueno,Yasuhito Imai, Shizuko Takahara, and Kiyofumi Saijoh.
  • Organizer: 9th Asian Aerosol Conference (AAC2015)
  • Place of Presentation: Kanazawa Tokyu Hotel, Kanazawa, Japan
  • Year and Date: 2015-06-25
  • Int'l Joint Research
• [Presentation] 黄砂を含む環境中化学物質の呼吸器疾患への影響に対するゼロ次予防 (2015)
  • Author(s): 中村裕之，神林康弘，東 朋美
  • Organizer: 第13回日本予防医学会学術集会
  • Place of Presentation: フレンドパーク石川（石川県勤労者福祉文化会館）
  • Year and Date: 2015-06-21
  • Invited
• [Presentation] 大気粒子状物質中PAHやPM2.5やSO2と成人慢性咳嗽患者における咳症状との関連 (2015)
  • Author(s): Anyenda Enoch Olando，神林康弘，東朋美，Nguyen Thi Thu Thao，道上義正，原丈介, 藤村政樹，辻口博聖，北岡政美，朝倉大貴，堀大介，三苫純子，中村剛，木戸康人, 能登裕幸，日比野由利，中村裕之.
  • Organizer: 第13回日本予防医学会学術集会
  • Place of Presentation: フレンドパーク石川（石川県勤労者福祉文化会館）
  • Year and Date: 2015-06-21
• [Presentation] 慢性咳嗽患者における重金属と目のかゆみと咳との関連-IgEレベルによる違い (2015)
  • Author(s): Nguyen Thi Thu Thao，神林康弘，東朋美，Anyenda Enoch Olando，道上義正，原丈介, 藤村政樹，辻口博聖，北岡政美，朝倉大貴，堀大介，三苫純子1)，中村剛，木戸康人, 能登裕幸，日比野由利，中村裕之.
  • Organizer: 第13回日本予防医学会学術集会
  • Place of Presentation: フレンドパーク石川（石川県勤労者福祉文化会館）
  • Year and Date: 2015-06-21
• [Presentation] 越境大気汚染の慢性咳嗽への影響評価 (2014)
  • Author(s): 東朋美、神林康弘、藤村政樹、早川和一、西條清史、杉本伸夫、中井里史、本田靖、小林史尚、人見嘉哲、中村裕之
  • Organizer: 第55回大気環境学会年会 健康影響分科会「越境大気汚染の健康影響評価とその課題
  • Place of Presentation: 愛媛大学城北キャンパス
  • Year and Date: 2014-09-17 – 2014-09-19
  • Invited
• [Presentation] Evaluation of Health Effects of Aerosol by Epidemiological Approach (2014)
  • Author(s): T. Higashi
  • Organizer: First Seminar of the JSPS Core-to-Core Program
  • Place of Presentation: Nagoya University, Nagoya, Japan
  • Year and Date: 2014-08-04 – 2014-08-09
  • Invited
• [Presentation] マクロ環境の話題（０次予防の取り組み例）～ 黄砂を含む環境中化学物質によるアレルギー疾患のゼロ次予防 (2014)
  • Author(s): 中村裕之、東 朋美
  • Organizer: 第12回 日本予防医学会学術集会 特別企画シンポジウム「革新的な予防医学の0次予防を加えた教育・研究の取り組み」
  • Place of Presentation: 日本科学未来館、東京
  • Year and Date: 2014-06-28 – 2014-06-29
  • Invited
• [Presentation] 黄砂と慢性咳嗽に関する臨床疫学 (2014)
  • Author(s): 東朋美、神林康弘、藤村政樹、西條清史、早川和一、杉本伸夫、中井里史、本田靖、人見嘉哲、中村裕之
  • Organizer: 第84回日本衛生学会学術総会 大気環境と健康に関する連携研究会シンポジウム「PM2.5と黄砂の健康影響update」
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-05-25 – 2014-05-27
  • Invited
• [Presentation] 黄砂の健康影響と予防法としてのサクランの活用 (2014)
  • Author(s): 東 朋美・中村裕之
  • Organizer: 第５回サクラン研究会 年次大会 第１２回 高資源循環ポリマーセンターシンポジウム
  • Place of Presentation: 北陸先端科学技術大学院大学マテリアルサイエンス研究科
• [Presentation] 黄砂と慢性咳嗽に関する臨床疫学 (2014)
  • Author(s): 東朋美、神林康弘、藤村政樹、西條清史、早川和一、杉本伸夫、中井里史、本田靖、人見嘉哲、中村裕之
  • Organizer: 第84回日本衛生学会学術総会 大気環境と健康に関する連携研究会シンポジウム
  • Place of Presentation: 岡山コンベンションセンター
  • Invited
• [Presentation] アスピリンが好塩基球のIgE依存的活性化に及ぼす影響.
  • Author(s): 堀井雅恵 福冨友馬、東馬智子、東朋美、北岡政美，三苫純子、朝倉大貴，神林康弘、人見嘉哲、谷地江昭宏、中村裕之.
  • Organizer: JSIT2013第20回日本免疫毒性学会学術大会
  • Place of Presentation: 東海大学代々木キャンパス