Factors involved in exacerbation of inflammation of metabolic syndrome and risk prediction using biomarkers

• Project/Area Number: 25460811
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Wakayama Medical University
• Principal Investigator: Takeshita Tatsuya 和歌山県立医科大学, 医学部, 教授 (20150310)
• Co-Investigator(Kenkyū-buntansha): 牟礼 佳苗 和歌山県立医科大学, 医学部, 准教授 (90268491)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 飲酒 / 多型 / アルコール脱水素酵素 / アルデヒド脱水素酵素 / アセトアルデヒド / アディポネクチン / メタボリックシンドローム / PPARG / 遺伝型 / 8-イソプロスタン / 酸化ストレス / 糖代謝 / インスリン抵抗性 / 脂質 / アルコール感受性 / 生活習慣 / 肥満

Outline of Final Research Achievements

We examined relationships between the ALDH2 and ADH1B genotypes, alcohol drinking behavior and serum adiponectin levels in 541 male workers. Total serum adiponectin, high molecular weight adiponectin levels in heavy drinkers (more than or equal to 12 units or more per week) were significantly lower than non- or light drinkers.
We examined relationships between the ALDH2 and ADH1B genotypes and alcohol sensitivity (facial flushing) or alcohol drinking behavior in 718 men (357 middle-aged and 361 older). We observed significant difference in alcohol sensitivity and alcohol drinking behavior only in the older men.

Research Products

• [Journal Article] Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men (2016)
  • Author(s): Hashimoto M, Watanabe M, Uematsu Y, Hattori S, Miyai N, Utsumi M, Oka M, Hayashida M, Kinoshita K, Arita M, Takeshita T
  • Journal Title: Environ Health Prev Med Volume: 21 Issue: 3 Pages: 138-148
  • DOI: 10.1007/s12199-016-0507-5
  • NAID: 50009953559
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Age and gender differences in the influences of eNOS T-786C polymorphism on arteriosclerotic parameters in general population in Japan (2016)
  • Author(s): Hashimoto M, Miyai N, Hattori S, Iwahara A, Utsumi M, Arita M, Takeshita T
  • Journal Title: Environ Health Prev Med Volume: 01 Apr Issue: 4 Pages: 1-9
  • DOI: 10.1007/s12199-016-0527-1
  • NAID: 210000000447
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Orthostatic blood pressure changes and subclinical markers of atherosclerosis (2015)
  • Author(s): Takahashi M, Miyai N, Nagano S, Utsumi M, Oka M, Yamamoto M, Shiba M, Uematsu Y, Nishimura Y, Takeshita T, and Arita M
  • Journal Title: Am J Hypertension Volume: 28 Issue: 9 Pages: 1134-1140
  • DOI: 10.1093/ajh/hpu301
  • Peer Reviewed
• [Journal Article] Urinary 8-iso-prostaglandin F2a as a marker of metabolic risks in the general Japanese population: The ROAD study. (2015)
  • Author(s): Mure K, Yoshimura N, Hashimoto M, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Takeshita T
  • Journal Title: Obesity 23:1517-1524, 2015. Volume: 23 Issue: 7 Pages: 1517-1524
  • DOI: 10.1002/oby.21130
  • Peer Reviewed
• [Journal Article] Genetic Polymorphisms in ADH1B and ALDH2 are Associated with Colorectal Tumors in Japan: A Case-control Study. (2015)
  • Author(s): Shiotani A, Ishikawa H, Mutoh M, Takeshita T, Nakamura T, Morimoto K, Sakai T, Wakabayashi K, Matsuura N
  • Journal Title: J Cancer Therapy Volume: 6 Issue: 12 Pages: 1054-1062
  • DOI: 10.4236/jct.2015.612115
• [Journal Article] Roles of the ALDH2 and ADH1B genotypes on the association between alcohol intake and serum adiponectin levels among Japanese male workers (2014)
  • Author(s): Maeda S, Mure K, Mugitani K, Watanabe Y, Iwane M, Mohara O, Takeshita T
  • Journal Title: Alcohol Clin Exp Res 38: 1559-1566, 2014 Volume: 38 Issue: 6 Pages: 1559-1566
  • DOI: 10.1111/acer.12406
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Habitual coffee consumption inversely associated with metabolic syndrome-related biomarkers involving adiponectin (2013)
  • Author(s): Mure K
  • Journal Title: Nutrition Volume: 29 Issue: 7-8 Pages: 982-987
  • DOI: 10.1016/j.nut.2013.01.011
  • Peer Reviewed
• [Journal Article] Is visceral fat really a coronary risk factor? (2013)
  • Author(s): Shimamoto Y
  • Journal Title: Int Heart J Volume: 54 Pages: 273-278
  • Peer Reviewed
• [Presentation] eNOS遺伝子多型が摂取塩分量と血圧・動脈硬化指標との関連に与える影響 (2015)
  • Author(s): 牟礼佳苗、橋本麿和、渡部益隆、岡檀、服部園美、宮井信行、内海みよ子、有田幹雄、竹下達也
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山市
  • Year and Date: 2015-03-27 – 2015-03-28
• [Presentation] PPARG遺伝子多型が加齢に伴う疾患に関する指標に与える影響 (2015)
  • Author(s): 渡部益隆、牟礼佳苗、橋本麿和、服部園美、宮井信行、内海みよ子、上松右二、有田幹雄、竹下達也
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山市
  • Year and Date: 2015-03-27 – 2015-03-28
• [Presentation] 日本人高齢者におけるAD1B、ALDH2遺伝子型と飲酒行動との関連 (2015)
  • Author(s): 橋本麿和、渡部益隆、服部園美、上松右二、有田幹雄、竹下達也
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山市
  • Year and Date: 2015-03-27 – 2015-03-28
• [Presentation] 地域コホートにおけるNutrigenetics研究－eNOS遺伝子多型と不飽和脂肪酸－ (2015)
  • Author(s): 牟礼佳苗、有田幹雄、竹下達也
  • Organizer: 第14回日本分子予防環境医学研究会
  • Place of Presentation: 大阪市
  • Year and Date: 2015-02-13 – 2015-02-14
• [Presentation] 日本人におけるeNOSのT-786C遺伝子型と動脈硬化との関連性 (2014)
  • Author(s): 橋本麿和
  • Organizer: 日本衛生学会
  • Place of Presentation: 岡山市
• [Presentation] 後期高齢者におけるPPARG遺伝子型と尿中イソプラスタン及び炎症マーカーとの関連 (2014)
  • Author(s): 渡部益隆
  • Organizer: 日本衛生学会
  • Place of Presentation: 岡山市