Chronic stress state promotes cancer metastatic ability
| Project/Area Number |
25460918
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Kinki University |
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Principal Investigator |
ICHIDA Seiji 近畿大学, 薬学部, 講師 (00125121)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIDA Shozo 近畿大学, 薬学部, 教授 (40208187)
FUNAKAMI Yoshinori 近畿大学, 薬学部, 講師 (70449833)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 慢性ストレス / がん / 転移 / 自然免疫 / マクロファージ / 肺胞マクロファージ / 貪食能 |
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| Outline of Final Research Achievements |
We investigated whether chronic stress influences on cancer metastatic ability using a lung cancer metastasis model B16BL6 cell. As a result, we obtained the following findings. 1) The cancer metastasis and the tumor growth in B16BL6 cell were promoted in chronically stressed mice. 2) The number of NK cell and alveolar macrophage and the phagocytic activity of the macrophage in the chronically stressed mice were decreased.
It is suggested from these results suggest that the cancer metastatic ability of B16BL6 cell in chronically stressed mice is prompted so that the immunocompetence of the alveolar macrophage is decreased in the chronically stressed mice.
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Report
(4 results)
Research Products
(6 results)
