Chronic stress state promotes cancer metastatic ability

• Project/Area Number: 25460918
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Kinki University
• Principal Investigator: ICHIDA Seiji 近畿大学, 薬学部, 講師 (00125121)
• Co-Investigator(Renkei-kenkyūsha): NISHIDA Shozo 近畿大学, 薬学部, 教授 (40208187) ; FUNAKAMI Yoshinori 近畿大学, 薬学部, 講師 (70449833)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 慢性ストレス / がん / 転移 / 自然免疫 / マクロファージ / 肺胞マクロファージ / 貪食能

Outline of Final Research Achievements

We investigated whether chronic stress influences on cancer metastatic ability using a lung cancer metastasis model B16BL6 cell. As a result, we obtained the following findings. 1) The cancer metastasis and the tumor growth in B16BL6 cell were promoted in chronically stressed mice. 2) The number of NK cell and alveolar macrophage and the phagocytic activity of the macrophage in the chronically stressed mice were decreased.
It is suggested from these results suggest that the cancer metastatic ability of B16BL6 cell in chronically stressed mice is prompted so that the immunocompetence of the alveolar macrophage is decreased in the chronically stressed mice.

Research Products

• [Presentation] SARTストレス誘発肺胞マクロファージ貪食能低下に対するβ2受容体刺激薬サルブタモールの改善効果とそのシグナル伝達経路について (2015)
  • Author(s): 植芝 慧子，大友 栞，杉原小雪，山村愛美，船上 仁範，和田 哲幸，市田 成志
  • Organizer: 日本薬学会 第135年会
  • Place of Presentation: デザイン・クリエイティブセンター神戸（兵庫県神戸市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] The adrenergic agonists improve the impaired phagocytosis of alveolar macrophages in chronically stressed mice (2014)
  • Author(s): Yoshinori Funakami, Keiko Ueshiba, Chisato Nishijima, Nozomi Tashiro, Tetsuyuki Wada, Seiji Ichida.
  • Organizer: Pharmacology 2014 (British Pharmacological Society)
  • Place of Presentation: London, England
  • Year and Date: 2014-12-16 – 2014-12-18
• [Presentation] SARTストレス誘発肺胞マクロファージの機能異常に対する自律神経系の関与 (2014)
  • Author(s): 植芝慧子，船上仁範，大友 栞，杉原小雪，山村愛美，和田哲幸，市田成志
  • Organizer: 生体機能と創薬シンポジウム2014
  • Place of Presentation: 近畿大学薬学部（大阪府東大阪市）
  • Year and Date: 2014-08-28 – 2014-08-29
• [Presentation] SARTストレスによる肺胞マクロファージの貪食能低下は交感神経系の活性化によって改善する (2014)
  • Author(s): 植芝慧子
  • Organizer: 日本薬学会 第134 年会（熊本）
  • Place of Presentation: 熊本市総合体育館（熊本県熊本市）
• [Presentation] Diazepam improves the functional disorder of the alveolar macrophage caused by chronic stress in mice (2013)
  • Author(s): 市田成志
  • Organizer: Pharmacology 2013
  • Place of Presentation: London, UK
• [Presentation] SARTストレスマウスから採取した肺胞マクロファージの貪食能に対するアドレナリン、ノルアドレナリンの効果
  • Author(s): 植芝慧子
  • Organizer: 第63回日本薬学会近畿支部総会・大会
  • Place of Presentation: 同志社女子大学薬学部（京都府京田辺市）