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Chronic stress state promotes cancer metastatic ability

Research Project

Project/Area Number 25460918
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionKinki University

Principal Investigator

ICHIDA Seiji  近畿大学, 薬学部, 講師 (00125121)

Co-Investigator(Renkei-kenkyūsha) NISHIDA Shozo  近畿大学, 薬学部, 教授 (40208187)
FUNAKAMI Yoshinori  近畿大学, 薬学部, 講師 (70449833)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords慢性ストレス / がん / 転移 / 自然免疫 / マクロファージ / 肺胞マクロファージ / 貪食能
Outline of Final Research Achievements

We investigated whether chronic stress influences on cancer metastatic ability using a lung cancer metastasis model B16BL6 cell. As a result, we obtained the following findings. 1) The cancer metastasis and the tumor growth in B16BL6 cell were promoted in chronically stressed mice. 2) The number of NK cell and alveolar macrophage and the phagocytic activity of the macrophage in the chronically stressed mice were decreased.
It is suggested from these results suggest that the cancer metastatic ability of B16BL6 cell in chronically stressed mice is prompted so that the immunocompetence of the alveolar macrophage is decreased in the chronically stressed mice.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 2013 Other

All Presentation (6 results)

  • [Presentation] SARTストレス誘発肺胞マクロファージ貪食能低下に対するβ2受容体刺激薬サルブタモールの改善効果とそのシグナル伝達経路について2015

    • Author(s)
      植芝 慧子,大友 栞,杉原小雪,山村愛美,船上 仁範,和田 哲幸,市田 成志
    • Organizer
      日本薬学会 第135年会
    • Place of Presentation
      デザイン・クリエイティブセンター神戸(兵庫県神戸市)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] The adrenergic agonists improve the impaired phagocytosis of alveolar macrophages in chronically stressed mice2014

    • Author(s)
      Yoshinori Funakami, Keiko Ueshiba, Chisato Nishijima, Nozomi Tashiro, Tetsuyuki Wada, Seiji Ichida.
    • Organizer
      Pharmacology 2014 (British Pharmacological Society)
    • Place of Presentation
      London, England
    • Year and Date
      2014-12-16 – 2014-12-18
    • Related Report
      2014 Research-status Report
  • [Presentation] SARTストレス誘発肺胞マクロファージの機能異常に対する自律神経系の関与2014

    • Author(s)
      植芝慧子,船上仁範,大友 栞,杉原小雪,山村愛美,和田哲幸,市田成志
    • Organizer
      生体機能と創薬シンポジウム2014
    • Place of Presentation
      近畿大学薬学部(大阪府東大阪市)
    • Year and Date
      2014-08-28 – 2014-08-29
    • Related Report
      2014 Research-status Report
  • [Presentation] SARTストレスによる肺胞マクロファージの貪食能低下は交感神経系の活性化によって改善する2014

    • Author(s)
      植芝慧子
    • Organizer
      日本薬学会 第134 年会(熊本)
    • Place of Presentation
      熊本市総合体育館(熊本県熊本市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Diazepam improves the functional disorder of the alveolar macrophage caused by chronic stress in mice2013

    • Author(s)
      市田成志
    • Organizer
      Pharmacology 2013
    • Place of Presentation
      London, UK
    • Related Report
      2013 Research-status Report
  • [Presentation] SARTストレスマウスから採取した肺胞マクロファージの貪食能に対するアドレナリン、ノルアドレナリンの効果

    • Author(s)
      植芝慧子
    • Organizer
      第63回日本薬学会近畿支部総会・大会
    • Place of Presentation
      同志社女子大学薬学部(京都府京田辺市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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