| Project/Area Number |
25460920
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Aizawa Emiko 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第三部, 科研費研究員 (00639049)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUDO SHIN 東北大学, 医学系研究科, 教授 (80199249)
MUSHIAKE HAJIME 東北大学, 大学院医学系研究科, 教授 (80219849)
KAWASHIMA RYUTA 東北大学, 加齢医学研究所, 教授 (90250828)
SUGIURA MOTOAKI 東北大学, 加齢医学研究所, 教授 (60396546)
KOCHIYAMA TAKANORI 株式会社 国際電気通信基礎技術研究所, 脳情報通信総合研究所, 研究員 (90380146)
SATO YASUHIRO 東北大学, 大学病院, 助教 (20375033)
SEKIGUCHI ATSUSHI 国立精神・神経医療研究センター, 室長 (50547289)
KANAZAWA MOTOYORI 東北大学, 医学系研究科, 准教授 (70323003)
KANO MICHIKO 東北大学, 学際科学フロンティア研究所所新領域創成研究部, 助教 (20344658)
MORISHITA JOE 医療法人 佐々木胃腸科, 医師 (00375031)
KOTOZAKI YUKA 福島県立医科大学, ふくしま国際医療科学センター, 助教 (10569578)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 過敏性腸症候群 / 意思決定 / アイオワギャンブリングタスク / 脳腸相関 / ｆMRI / 直観的意思決定 / アイオワギャンブリング |
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| Outline of Final Research Achievements |
Patients with irritable bowel syndrome (IBS) exhibited an exaggerated sensorimotor function of the gastrointestinal tract in response to stress. However, the emotion-cognition sequence is largely unknown for IBS. We hypothesized that brain processing in individuals with IBS, during decision making, is different from that of healthy controls, due to increased activity of the insula and anterior cingulate cortex (ACC) as well as altered connectivity among brain regions. The results suggested that IBS subjects had significantly more advantageous card selections and gaining money.The dorsolateral prefrontal cortex (DLPFC) in IBS subjects is likely to be activated during decision making under ambiguity. Moreover, dynamic causal modeling analysis during decision making revealed significantly different connectivity in subjects with IBS, compared with controls. These findings suggested that gut feeling is involved in decision making individuals with IBS.
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