Role of Macrophage migration inhibitory factor in non-alcoholic steatohepatitis

• Project/Area Number: 25460968
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hokkaido University
• Principal Investigator: OHKAWARA Tatsuya 北海道大学, 薬学研究科(研究院), 研究員 (00374257)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Hiroshi 北海道大学, 薬学研究院臨床病態解析学, 教授 (60261294) ; OHNISHI Shunsuke 北海道大学, 大学病院, 講師 (10443475)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: マクロファージ遊走阻止因子 / 非アルコール性脂肪性肝炎 / 薬剤性肝障害 / コリン・メチオニン欠損食 / アセトアミノフェン / 非アルコール性脂肪肝炎 / 肝線維化

Outline of Final Research Achievements

We investigate the role of macrophage migration inhibitory factor (MIF) in non alcoholic steatohepatitis (NASH) using animal model. Methionine and choline-deficient diet(MCD) induces NASH in mice. The expression of MIF was up-regulated in liver of mice given MCD. However, ISO-1, an inhibitor of MIF bioactivity, did not ameliorated the severity of NASH in mice. In another hepatitis model induced by acetaminophene, ISO-1 reduced the severity of liver injury and decrease the level of inflammatory mediater. Taken together, our data suggest that the role of MIF is perplexing in NASH.