Evaluation and investigation between the risk of cardiovascular disease and SNP-environment interaction in the company labor men

• Project/Area Number: 25461052
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Fujita Health University
• Principal Investigator: Hayashi Mutsuharu 藤田保健衛生大学, 医学部, 准教授 (70426500)
• Co-Investigator(Kenkyū-buntansha): YASUDA YOSHINARI 名古屋大学, 大学院医学系研究科, 准教授 (60432259) ; HONDA HIROYUKI 名古屋大学, 大学院工学系研究科, 教授 (70209328)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 遺伝子多型 / 遺伝子環境相互因子 / 生活習慣病 / 労働男性 / 遺伝子環境相互作用 / マイクロRNA / 慢性腎臓病 / 慢性心臓病 / 高血圧

Outline of Final Research Achievements

We performed a case-control study to explore novel SNP × clinical parameter(CP) interactions as risk markers for MetS based on health check-up data of Japanese male employees. After selection of 99 SNPs that were previously reported to be associated with MetS and components of MetS, we performed logistic regression analyses to assess the association of each SNP with MetS. Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05). Then we performed multiple logistic regression analyses, including an SNP term, a CP term, and an SNP × CP interaction term for each CP and SNP that was significantly associated with MetS. We identified a novel SNP × CP interaction between rs7965413 and platelet count that was significantly associated with MetS (P < 0.01). We publised these results as an English paper.

Research Products

• [Journal Article] Impact of circulating cathepsin K on the coronary calcification and the clinical outcome in chronic kidney disease patients. (2016)
  • Author(s): Izumi Y, Hayashi M, Morimoto R, Cheng XW, Wu H, Ishii H, Yasuda Y, Yoshikawa D, Izawa H, Matsuo S, Oiso Y, Murohara T
  • Journal Title: Heart and Vessels Volume: 31(1) Pages: 6-14
  • Peer Reviewed
• [Journal Article] Clinical Characteristics and Long-Term Outcomes of Hypertrophic Cardiomyopathy. (2015)
  • Author(s): Yoshinaga M, Yoshikawa D, Ishii H, Hirashiki A, Okumura T, Kubota A, Sakai S, Harada K, Somura F, Mizuno T, Fujiwara W, Yokoi H, Hayashi M, Ishii J, Ozaki Y, Murohara T, Yoshida Y, Amano T, Izawa H.
  • Journal Title: International Heart Journal Volume: 56(4) Pages: 415-420
  • Peer Reviewed
• [Journal Article] Impact of abdominal aortic calcification on long-term cardiovascular outcomes in patients with chronic kidney disease. (2015)
  • Author(s): Tatami Y, Yasuda Y, Suzuki S, Ishii H, Sawai A, Shibata Y, Ota T, Shibata K, Niwa M, Morimoto R, Hayashi M, Kato S, Maruyama S, Murohara T.
  • Journal Title: Atherosclerosis Volume: 243(2) Pages: 349-355
  • Peer Reviewed
• [Journal Article] Impact of non-invasive cardiovascular screening programs as a predictor of cardiovascular events among asymptomatic chronic kidney disease patients. (2015)
  • Author(s): Sawai A, Yasuda Y, Suzuki S, Ishii H, Goto M, Kato S, Hayashi M, Maruyama S, Murohara T, Oiso Y, Matsuo S
  • Journal Title: Clinical and Experimental Nephrology Volume: 20(3) Pages: 416-24
  • Peer Reviewed
• [Journal Article] Left ventricular dyssynchrony in patients with moderate coronary stenosis and border line fractional flow reserve. (2015)
  • Author(s): Shibata Y, Sone T, Tsuboi H, Isobe S, Ishii H, Suzuki S, Hayashi M, Murohara T
  • Journal Title: Nagoya journal of medical science Volume: 77(1-2) Pages: 155-166
  • NAID: 120005549561
  • Peer Reviewed
• [Journal Article] Identification of an interaction between VWF rs7965413 and platelet count as a novel risk marker for metabolic syndrome: an extensive search of candidate polymorphisms in a case-control study. (2015)
  • Author(s): Nakatochi M, Ushida Y, Yasuda Y, Yoshida Y, Kawai S, Kato R, Nakashima T, Iwata M, Kuwatsuka Y, Ando M, Hamajima N, Kondo T, Oda H, Hayashi M, Kato S, Yamaguchi M, Maruyama S, Matsuo S, Honda H.
  • Journal Title: PLoS One Volume: 10(2)
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 特発性拡張型心筋症患者の末梢血マイクロRNAの網羅的解析と定量評価 (2015)
  • Author(s): 林 睦晴
  • Organizer: 心筋症研究会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-04
• [Presentation] Impact of Indoxyl sulfate on the progression of endothelial dysfunction and atherosclerosis in chronic kidney disease patients (2014)
  • Author(s): M. Hayashi, H. Ishii, H. Izawa, T. Murohara
  • Organizer: ESC congress 2014
  • Place of Presentation: Barcelona
  • Year and Date: 2014-08-30 – 2014-09-04