Influence of diurnal blood glucose fluctuation on myocardial salvage in acute phase after myocardial infarction and establishment of its treatment
Project/Area Number |
25461063
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
|
Research Institution | Wakayama Medical University |
Principal Investigator |
Teraguchi Ikuko 和歌山県立医科大学, 医学部, 博士研究員 (70549782)
|
Co-Investigator(Kenkyū-buntansha) |
今西 敏雄 和歌山県立医科大学, 医学部, 博士研究員 (00285389)
|
Project Period (FY) |
2013-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 血糖日内変動 / 急性心筋梗塞 / 心筋救済率 / DPP4阻害剤 / DPP-4阻害剤 / DPP-4阻害薬 / 心筋救済 / 国際情報交換 |
Outline of Final Research Achievements |
The effect of diurnal blood glucose fluctuation in type 2 diabetes acute myocardial infarction cases acute phase on myocardial salvage and chronic left ventricular remodeling, clarifying the mechanism related to them, and the therapeutic intervention effect by DPP4 inhibitor I have been researching. We announced that "stress hyperglycemia in the acute phase is a factor for myocardial salvage in patients with acute myocardial infarction" and "average blood glucose fluctuation in acute phase is a factor for myocardial salvage in patients with acute myocardial infarction". He also announced that "average blood glucose variability affects coronary plaque rupture". Furthermore, we reported that the myocardial rescue rate is improved through the improvement of blood glucose fluctuation range by the intervention of DPP4 inhibitor, the improvement of peripheral monocyte subsets, and the active glucagon-like peptide 1.
|
Academic Significance and Societal Importance of the Research Achievements |
心筋梗塞後の心筋救済率は、慢性期の左室モデリングに悪影響を与え、長期予後に関与する。特に心筋梗塞急性期の高血糖のみならず、血糖日内変動の増大は心筋救済率に悪影響を及ぼすことが明らかとなった。心筋梗塞急性期の血糖変動の増大への治療介入が心筋救済率改善に影響する可能性があるとして、本研究を行ってきた。急性心筋梗塞症例のうち2型糖尿病罹患症例のうち、心筋梗塞発症急性期のビルダグリプチン投与例で有意な血糖変動の平定化が認められ、薬剤介入群では心筋救済率は高いものであった。心筋梗塞発症急性期のビルダグリプチン投与は、急性期血糖変動を平定化させ、心筋救済率に良い影響を与える可能性が示唆された。
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Report
(7 results)
Research Products
(8 results)
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[Journal Article] Acute-Phase Glucose Fluctuation Is Negatively Correlated With Myocardial Salvage After Acute Myocardial Infarction2014
Author(s)
Ikuko Teraguchi, MD; Toshio Imanishi, MD, PhD; Yuichi Ozaki, MD; Takashi Tanimoto, MD, PhD; Makoto Orii, MD; Yasutsugu Shiono, MD; Kunihiro Shimamura, MD; Kohei Ishibashi, MD; Takashi Yamano, MD; Yasushi Ino, MD, PhD; Tomoyuki Yamaguchi, MD; Kumiko Hirata, MD, PhD; Takashi Kubo, MD, PhD; and Takashi Akasaka, MD, PhD
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Journal Title
Circulation Journal
Volume: 78
Pages: 170-179
Related Report
Peer Reviewed
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[Journal Article] Impact of Glucose Fluctuation and Monocyte Subsets on Coronary Plaque Rupture2014
Author(s)
Ikuko Teraguchi, MD; Toshio Imanishi, MD, PhD; Yuichi Ozaki, MD; Takashi Tanimoto, MD, PhD; Makoto Orii, MD; Yasutsugu Shiono, MD; Kunihiro Shimamura, MD; Kohei Ishibashi, MD; Takashi Yamano, MD; Yasushi Ino, MD, PhD; Tomoyuki Yamaguchi, MD; Kumiko Hirata, MD, PhD; Takashi Kubo, MD, PhD; and Takashi Akasaka, MD, PhD
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Journal Title
Nutrition, Metabolism & Cardiovascular Disease
Volume: 24
Pages: 309-314
Related Report
Peer Reviewed
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[Presentation] Impact of glucose fluctuation and monocyte subsets on coronary plaque rupture2013
Author(s)
Teraguchi I, Imanishi T, Ozaki Y, Tanimoto T, Yamano T, Ino Y, Yamaguchi T, Hirata K, Kubo T, Akasaka T
Organizer
European Society Cardiology Congress
Place of Presentation
Amsterdam, Netherlands
Related Report
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[Presentation] 急性期の平均血糖変動幅(MAGE)は急性心筋梗塞(AMI)患者における心筋救済の因子である.2013
Author(s)
寺口郁子, 今西敏雄, 尾﨑雄一, 折居 誠, 塩野泰紹, 谷本貴志, 山野貴司, 山口智由, 平田久美子, 久保隆史, 今西敏雄, 久保隆史, 赤阪隆史
Organizer
第61回日本心臓病学会学術集会
Place of Presentation
熊本県熊本市
Related Report
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[Presentation] 平均血糖変動幅(MAGE)は冠動脈プラーク破裂に影響を与える.2013
Author(s)
寺口郁子, 今西敏雄, 尾﨑雄一, 折居 誠, 塩野泰紹, 谷本貴志, 山野貴司, 山口智由, 平田久美子, 久保隆史, 赤阪隆史
Organizer
第61回日本心臓病学会学術集会
Place of Presentation
熊本県熊本市
Related Report
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[Presentation] 平均血糖変動幅(MAGE)は冠動脈プラーク破裂に栄光を与える2013
Author(s)
寺口郁子, 今西敏雄, 尾﨑雄一, 西口 毅, 下角あい子, 嶋村邦宏, 折居 誠, 塩野泰紹, 谷本貴志, 山野貴司, 猪野 靖, 山口智由, 平田久美子, 久保隆史, 赤阪隆史
Organizer
第27回日本冠疾患学会学術集会
Place of Presentation
和歌山県和歌山市
Related Report
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[Presentation] 急性期の平均血糖変動幅(MAGE)は急性心筋梗塞(AMI)患者における心筋救済の因子である2013
Author(s)
寺口郁子, 今西敏雄, 尾﨑雄一, 折居 誠, 塩野泰紹, 谷本貴志, 山野貴司, 山口智由, 平田久美子, 久保隆史, 今西敏雄, 久保隆史, 赤阪隆史 :
Organizer
第21回日本血管生物医学会学術集会
Place of Presentation
大阪市豊中市
Related Report