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Influence of diurnal blood glucose fluctuation on myocardial salvage in acute phase after myocardial infarction and establishment of its treatment

Research Project

Project/Area Number 25461063
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionWakayama Medical University

Principal Investigator

Teraguchi Ikuko  和歌山県立医科大学, 医学部, 博士研究員 (70549782)

Co-Investigator(Kenkyū-buntansha) 今西 敏雄  和歌山県立医科大学, 医学部, 博士研究員 (00285389)
Project Period (FY) 2013-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords血糖日内変動 / 急性心筋梗塞 / 心筋救済率 / DPP4阻害剤 / DPP-4阻害剤 / DPP-4阻害薬 / 心筋救済 / 国際情報交換
Outline of Final Research Achievements

The effect of diurnal blood glucose fluctuation in type 2 diabetes acute myocardial infarction cases acute phase on myocardial salvage and chronic left ventricular remodeling, clarifying the mechanism related to them, and the therapeutic intervention effect by DPP4 inhibitor I have been researching. We announced that "stress hyperglycemia in the acute phase is a factor for myocardial salvage in patients with acute myocardial infarction" and "average blood glucose fluctuation in acute phase is a factor for myocardial salvage in patients with acute myocardial infarction". He also announced that "average blood glucose variability affects coronary plaque rupture". Furthermore, we reported that the myocardial rescue rate is improved through the improvement of blood glucose fluctuation range by the intervention of DPP4 inhibitor, the improvement of peripheral monocyte subsets, and the active glucagon-like peptide 1.

Academic Significance and Societal Importance of the Research Achievements

心筋梗塞後の心筋救済率は、慢性期の左室モデリングに悪影響を与え、長期予後に関与する。特に心筋梗塞急性期の高血糖のみならず、血糖日内変動の増大は心筋救済率に悪影響を及ぼすことが明らかとなった。心筋梗塞急性期の血糖変動の増大への治療介入が心筋救済率改善に影響する可能性があるとして、本研究を行ってきた。急性心筋梗塞症例のうち2型糖尿病罹患症例のうち、心筋梗塞発症急性期のビルダグリプチン投与例で有意な血糖変動の平定化が認められ、薬剤介入群では心筋救済率は高いものであった。心筋梗塞発症急性期のビルダグリプチン投与は、急性期血糖変動を平定化させ、心筋救済率に良い影響を与える可能性が示唆された。

Report

(7 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] Acute-Phase Glucose Fluctuation Is Negatively Correlated With Myocardial Salvage After Acute Myocardial Infarction2014

    • Author(s)
      Ikuko Teraguchi, MD; Toshio Imanishi, MD, PhD; Yuichi Ozaki, MD; Takashi Tanimoto, MD, PhD; Makoto Orii, MD; Yasutsugu Shiono, MD; Kunihiro Shimamura, MD; Kohei Ishibashi, MD; Takashi Yamano, MD; Yasushi Ino, MD, PhD; Tomoyuki Yamaguchi, MD; Kumiko Hirata, MD, PhD; Takashi Kubo, MD, PhD; and Takashi Akasaka, MD, PhD
    • Journal Title

      Circulation Journal

      Volume: 78 Pages: 170-179

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of Glucose Fluctuation and Monocyte Subsets on Coronary Plaque Rupture2014

    • Author(s)
      Ikuko Teraguchi, MD; Toshio Imanishi, MD, PhD; Yuichi Ozaki, MD; Takashi Tanimoto, MD, PhD; Makoto Orii, MD; Yasutsugu Shiono, MD; Kunihiro Shimamura, MD; Kohei Ishibashi, MD; Takashi Yamano, MD; Yasushi Ino, MD, PhD; Tomoyuki Yamaguchi, MD; Kumiko Hirata, MD, PhD; Takashi Kubo, MD, PhD; and Takashi Akasaka, MD, PhD
    • Journal Title

      Nutrition, Metabolism & Cardiovascular Disease

      Volume: 24 Pages: 309-314

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Impact of glucose fluctuation and monocyte subsets on coronary plaque rupture2013

    • Author(s)
      Teraguchi I, Imanishi T, Ozaki Y, Tanimoto T, Yamano T, Ino Y, Yamaguchi T, Hirata K, Kubo T, Akasaka T
    • Organizer
      European Society Cardiology Congress
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2013 Research-status Report
  • [Presentation] 急性期の平均血糖変動幅(MAGE)は急性心筋梗塞(AMI)患者における心筋救済の因子である.2013

    • Author(s)
      寺口郁子, 今西敏雄, 尾﨑雄一, 折居 誠, 塩野泰紹, 谷本貴志, 山野貴司, 山口智由, 平田久美子, 久保隆史, 今西敏雄, 久保隆史, 赤阪隆史
    • Organizer
      第61回日本心臓病学会学術集会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2013 Research-status Report
  • [Presentation] 平均血糖変動幅(MAGE)は冠動脈プラーク破裂に影響を与える.2013

    • Author(s)
      寺口郁子, 今西敏雄, 尾﨑雄一, 折居 誠, 塩野泰紹, 谷本貴志, 山野貴司, 山口智由, 平田久美子, 久保隆史, 赤阪隆史
    • Organizer
      第61回日本心臓病学会学術集会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2013 Research-status Report
  • [Presentation] 平均血糖変動幅(MAGE)は冠動脈プラーク破裂に栄光を与える2013

    • Author(s)
      寺口郁子, 今西敏雄, 尾﨑雄一, 西口 毅, 下角あい子, 嶋村邦宏, 折居 誠, 塩野泰紹, 谷本貴志, 山野貴司, 猪野 靖, 山口智由, 平田久美子, 久保隆史, 赤阪隆史
    • Organizer
      第27回日本冠疾患学会学術集会
    • Place of Presentation
      和歌山県和歌山市
    • Related Report
      2013 Research-status Report
  • [Presentation] 血糖変動と心血管病2013

    • Author(s)
      寺口郁子
    • Organizer
      第2回若手医師のためのハンズオンセミナー
    • Place of Presentation
      和歌山県和歌山市
    • Related Report
      2013 Research-status Report
  • [Presentation] 急性期の平均血糖変動幅(MAGE)は急性心筋梗塞(AMI)患者における心筋救済の因子である2013

    • Author(s)
      寺口郁子, 今西敏雄, 尾﨑雄一, 折居 誠, 塩野泰紹, 谷本貴志, 山野貴司, 山口智由, 平田久美子, 久保隆史, 今西敏雄, 久保隆史, 赤阪隆史 :
    • Organizer
      第21回日本血管生物医学会学術集会
    • Place of Presentation
      大阪市豊中市
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2020-03-30  

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