| Project/Area Number |
25461097
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Foundation for Biomedical Research and Innovation |
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Principal Investigator |
Kaji Shuichiro 公益財団法人先端医療振興財団, その他部局等, 研究員 (80330554)
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| Co-Investigator(Kenkyū-buntansha) |
SENDA Michio 先端医療振興財団, 映像医療開発部門, 部門長 (00216558)
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| Research Collaborator |
OHNISHI Akihito 先端医療振興財団, 研究員
KITAI Takeshi 神戸市立医療センター中央市民病院, 循環器内科
MURAI Ryosuke 神戸市立医療センター中央市民病院, 循環器内科
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 急性大動脈症候群 / 急性大動脈解離 / PET/CT検査 / FDG-PET / 大動脈解離 / 偽腔閉塞型大動脈解離 / 偽腔開存型大動脈解離 / PET-CT検査 / PET-CT |
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| Outline of Final Research Achievements |
Acute aortic syndrome (AAS) is life-threatening disease and risk stratification is crucial for choosing a suitable therapy. It has been reported that elevated circulating markers of inflammation are associated with adverse outcomes in patients with AAS. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) may have potent diagnostic effects in the imaging of aortic wall inflammation. We aim to investigate the clinical significance of FDG-PET in patients with AAS. A total of 59 AAS patients underwent FDG-PET during acute phase. The standardized uptake value (SUV) and total FDG activity (t-FDG) were measured. As a result, patients with higher t-FDG had significantly worse prognosis compared to those with lower t-FDG. We conclude that greater uptake of 18F-FDG was associated with an increased risk of aorta-related events in patients with AAS, which suggests that FDG-PET might be useful for risk stratification in AAS patients.
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