Extracorporeal low-energy shock wave therapy exerts anti-inflammatory effects in a rat model of acute myocardial infarction
| Project/Area Number |
25461099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
Ito Kenta 東北大学, 医学(系)研究科(研究院), 准教授 (50375086)
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| Co-Investigator(Kenkyū-buntansha) |
Shimokawa Hiroaki 東北大学, 大学院医学系研究科, 教授 (00235681)
Kawakami Kazuyoshi 東北大学, 大学院医学系研究科, 教授 (10253973)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 低出力体外衝撃波治療 / 血管新生 / 急性心筋梗塞 / 左室リモデリング / 抗炎症作用 |
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| Outline of Final Research Achievements |
It has been previously demonstrated that extracorporeal low-energy shock-wave (SW) therapy ameliorates left ventricular (LV) remodeling through enhanced angiogenesis after acute myocardial infarction (AMI) in pigs in vivo. However, it remains to be examined whether SW therapy also exerts anti-inflammatory effects on AMI.
In the present study, we have reported that low-energy shock wave therapy suppressed post-MI LV remodeling in rats in vivo, which was associated with anti-inflammatory effects in addition to its angiogenic effects.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] 心血管疾患に対する非侵襲性再生医療の開発：低出力体外衝撃波治療2014
Author(s)
伊藤健太, 進藤智彦, 尾形剛, 畠中和明, 芹澤玄, 河村圭一郎, 高橋潤, 松本泰治, 圓谷隆治, 羽尾清貴, 西宮健介, 二瓶太郎, 小鷹悠二, 塙健一郎, 長谷部雄飛, 宇塚裕紀, 平野道基, 後藤均, 下川宏明
Organizer
第53回日本生体医工学会大会
Place of Presentation
仙台
Year and Date
2014-06-24 – 2014-06-26
Related Report
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[Presentation] Extracorporeal Low-Energy Shock Wave Therapy Improves Left Ventricular Remodeling and Reduces Inflammatory Responses after Acute Myocardial Infarction in Rats2014
Author(s)
Yuzuru Abe, Kenta Ito, Kiyotaka Hao, Kenichiro Hanawa, Tomohiko Shindo, Kensuke Nishimiya, Yuhi Hasebe, Hiroaki Yamamoto, Kimio Satoh, Kazuyoshi Kawakami, Hiroaki Shimokawa
Organizer
第78回日本循環器学会学術集会
Place of Presentation
東京
Related Report
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