Analysis of metabolic syndrome on allergic diseases.

• Project/Area Number: 25461168
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Tokyo National Hospital (Clinical research)
• Principal Investigator: Suzukawa Maho 独立行政法人国立病院機構東京病院(臨床研究部), その他部局等, その他 (20453699)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 喘息 / 肥満 / レプチン / 気道上皮細胞 / アディポカイン

Outline of Final Research Achievements

The present study investigated the effects of leptin on human airway epithelial cells by using human primary airway epithelial cells and a human airway epithelial cell line, BEAS-2B. Airway epithelial cells expressed leptin receptor (Ob-R). Leptin enhanced ICAM-1 expression and production of CCL11, G-CSF, VEGF, and IL-6 by BEAS-2B cells. Leptin induced migration of primary airway epithelial cells toward leptin, suppressed BEAS-2B apoptosis, and enhanced proliferation of primary airway epithelial cells. In summary, leptin was able to directly activate human airway epithelial cells.

Research Products

• [Journal Article] Leptin enhances ICAM-1 expression, induces migration and cytokine synthesis, and prolongs survival of human airway epithelial cells. (2015)
  • Author(s): Suzukawa M, Koketsu R, Baba S, Igarashi S, Nagase H, Yamaguchi M, Matsutani N, Kawamura M, Shoji S, Hebisawa A, Ohta K.
  • Journal Title: Am J Physiol Lung Cell Mol Physiol Volume: 309 Issue: 8 Pages: L801-L811
  • DOI: 10.1152/ajplung.00365.2014
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Modulation of human basophil activation by resveratrol (2015)
  • Author(s): Tanaka Y, Yamaguchi M, Suzukawa M, Arai H, Nagase H, Ohta K.
  • Journal Title: Allergology International Volume: 64 Issue: Supplement.1 Pages: 80-82
  • DOI: 10.1016/j.alit.2015.05.003
  • NAID: 130005290376
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of clinical characteristics and prognosis of chronic pulmonary aspergillosis depending on the underlying lung diseases: Emphysema vs prior tuberculosis. (2015)
  • Author(s): Koyama K, Ohshima N, Suzuki J, Kawashima M, Okuda K, Sato R, Suzukawa M, Nagai H, Matsui H, Ohta K.
  • Journal Title: J Infect Chemother Volume: 21 Issue: 11 Pages: 00189-0
  • DOI: 10.1016/j.jiac.2015.08.006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development. (2015)
  • Author(s): Niki M, Suzukawa M, Akashi S, Nagai H, Ohta K, Inoue M, Niki M, Kaneko Y, Morimoto K, Kurashima A, Kitada S, Matsumoto S, Suzuki K, Hoshino Y.
  • Journal Title: J Immunol Res Volume: 2015 Pages: 527395-527395
  • DOI: 10.1155/2015/527395
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients. (2015)
  • Author(s): Baba S, Kagoya R, Kondo K, Suzukawa M, Ohta K, Yamasoba T.
  • Journal Title: Allergy Asthma Clin Immunol Volume: 11 Issue: 1 Pages: 33-33
  • DOI: 10.1186/s13223-015-0100-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ORMDL3 Transgenic Mice Have Increased Airway Remodeling and Airway Responsiveness Characteristic of Asthma. (2014)
  • Author(s): Miller M, Rosenthal P, Beppu A, Mueller JL, Hoffman HM, Tam AB, Doherty TA, McGeough MD, Pena CA, Suzukawa M, Niwa M, Broide DH.
  • Journal Title: J Immunol. Volume: 192 Issue: 8 Pages: 3475-87
  • DOI: 10.4049/jimmunol.1303047
  • Peer Reviewed / Open Access
• [Journal Article] Local increase in IgE and class switch recombination to IgE in nasal polyps in chronic rhinosinusitis. (2014)
  • Author(s): Baba S, Kondo K, Toma-Hirano M, Kanaya K, Suzukawa K, Ushio M, Suzukawa M, Ohta K, Yamasoba T.
  • Journal Title: Clin Exp Allergy Volume: 44 Issue: 5 Pages: 701-712
  • DOI: 10.1111/cea.12287
  • Peer Reviewed
• [Journal Article] Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria. (2014)
  • Author(s): Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-Hora M, Akashi K, Yamasaki S.
  • Journal Title: Immunity Volume: 41 Issue: 3 Pages: 402-13
  • DOI: 10.1016/j.immuni.2014.08.005
  • Peer Reviewed / Open Access
• [Journal Article] Expression of IL-33 and its receptor ST2 in chronic rhinosinusitis with nasal polyp (2014)
  • Author(s): Baba S, Kondo K, Kanaya K, Suzukawa K, Ushio M, Urata S, Asakage T, Kakigi A, Suzukawa M, Ohta K, Yamasoba T.
  • Journal Title: Laryngoscope Volume: 124 Issue: 4 Pages: 115-122
  • DOI: 10.1002/lary.24462
  • Peer Reviewed
• [Journal Article] Modulation of Human Basophil Degranulation by Geranylgeranyl Compounds (2014)
  • Author(s): Nakase Y, Yamaguchi M, Sugimoto N, Suzukawa M, Arai H, Nagase H, Ohta K.
  • Journal Title: Allergology International Volume: 63 Issue: Supplement.1 Pages: S49-S51
  • DOI: 10.2332/allergolint.13-LE-0637
  • NAID: 130004477225
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Immunological responses and epitope mapping by tuberculosis-associated antigens within the RD1 region in Japanese patients (2014)
  • Author(s): Nagai H, Suzukawa M, Sakakibara Y, Ohta K, Reche PA, Suzuki Kand Hoshino Y
  • Journal Title: Clinical and Developmental Immunology Volume: 2014 Pages: 764028-764028
  • DOI: 10.1155/2014/764028
  • Peer Reviewed
• [Journal Article] Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice. (2013)
  • Author(s): Suzukawa M, Miller M, Rosenthal P, Cho JY, Doherty TA, Varki A, Broide D.
  • Journal Title: J Immunol. Volume: 190 Issue: 12 Pages: 5939-48
  • DOI: 10.4049/jimmunol.1203455
  • Peer Reviewed
• [Journal Article] Pretreatment with low levels of FcεRI-crosslinking stimulation enhances basophil mediator release. (2013)
  • Author(s): Koketsu R, Yamaguchi M, Suzukawa M, Tanaka Y, Tashimo H, Arai H, Nagase H, Matsumoto K, Saito H, Ra C, Yamamoto K, Ohta K.
  • Journal Title: Int Arch Allergy Immunol. Volume: 161 Issue: Suppl. 2 Pages: 23-31
  • DOI: 10.1159/000350339
  • Peer Reviewed
• [Journal Article] IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis (2013)
  • Author(s): Nakanishi W, Yamaguchi S, Matsuda A, Suzukawa M, Shibui A, Nambu A, Kondo K, Suto H, Saito H, Matsumoto K, Yamasoba T, Nakae S
  • Journal Title: PLoS ONE Volume: 8 Issue: 10 Pages: e78099-e78099
  • DOI: 10.1371/journal.pone.0078099
  • Peer Reviewed
• [Presentation] Analysis of asthma control and inflammatory mediators in severe asthmatics during omalizumab therapy (2015)
  • Author(s): 鈴川真穂、大島信治、田下浩之、長瀬洋之、山口正雄、庄司俊輔、小林信之、蛇澤晶、大田健
  • Organizer: The 25th Congress of Interasma Japan/North Asia
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2015-09-03
  • Int'l Joint Research
• [Presentation] 重症成人喘息に対するオマリズマブ使用の効果予測因子の検討 (2015)
  • Author(s): 鈴川真穂、大島信治、田下浩之、長瀬洋之、山口正雄、庄司俊輔、小林信之、蛇澤晶、大田健
  • Organizer: 第64回日本アレルギー学会学術大会
  • Place of Presentation: 東京都港区
  • Year and Date: 2015-05-26
• [Presentation] Leptin induces migration and cytokine production, and inhibits apoptosis, of human airway epithelial cells (2015)
  • Author(s): Maho Suzukawa, Rikiya Koketsu, Shintaro Baba, Sayaka Igarashi, Hiroyuki Nagase, Masao Yamaguchi, Noriyuki Matsutani, Masafumi Kawamura, Shunsuke Shoji, Akira Hebisawa, and Ken Ohta
  • Organizer: American Thoracic Society 2015 International Conference
  • Place of Presentation: Colorado, USA
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Presentation] レプチンによる気道上皮細胞の活性化 (2015)
  • Author(s): 鈴川真穂、纐纈力也、長瀬洋之、山口正雄、松谷哲行、川村雅文、庄司俊輔、蛇澤晶、大田健
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2015-04-17
• [Presentation] Leptin induces cytokine synthesis by human airway epithelial cell line by signaling via its receptor, Ob-R (2014)
  • Author(s): Maho Suzukawa, Rikiya Koketsu, Hiroyuki Nagase, Masao Yamaguchi, Ken Ohta
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10
• [Presentation] Regulatory roles of basophils in Th2 immune responses (2014)
  • Author(s): 鈴川真穂
  • Organizer: International Symposium on Homeostasis through development, life, and diseases
  • Place of Presentation: 群馬
  • Year and Date: 2014-11-07
  • Invited
• [Presentation] レプチンによるヒト気道上皮細胞株(BEAS-2B)のサイトカイン産生増強作用 (2014)
  • Author(s): 鈴川真穂、纐纈力也、田下浩之、大島信治、長瀬洋之、山口正雄、小林信之、庄司俊輔、蛇澤晶、大田健
  • Organizer: 第24回国際喘息学会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-08-18
• [Presentation] 好塩基球が重症喘息に関与している可能性（基礎） (2014)
  • Author(s): 鈴川真穂
  • Organizer: 第34回六甲カンファレンス
  • Place of Presentation: 京都
  • Year and Date: 2014-07-26
  • Invited
• [Presentation] 炎症細胞を標的としたアレルギー疾患に対する新規治療法の可能性：Siglecを中心としたトピックス (2014)
  • Author(s): 鈴川真穂
  • Organizer: 第１回東京Asthma & COPD研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-27
  • Invited
• [Presentation] omalizumabによる好塩基球感作抑制を利用したin vitroでのIgE関与の証明
  • Author(s): 山口 正雄, 鈴川 真穂, 小泉 佑太, 田中 祐輔, 中瀬 裕子, 杉本 直也, 戸田 貴子, 田宮 浩之, 小島 康弘, 吉原 久直, 倉持 美知雄, 田嶋 誠, 田下 浩之, 新井 秀宜, 長瀬 洋之, 大田 健
  • Organizer: 日本職業・環境アレルギー学会総会・学術大会
  • Place of Presentation: 相模大野
• [Presentation] 平成24年以降に原因検索を行ったアナフィラキシー等の急性アレルギー症状成人110症例のまとめ 無視できないアニサキスの高頻度
  • Author(s): 中瀬 裕子, 高橋 美圭, 小泉 佑太, 田中 祐輔, 杉本 直也, 戸田 貴子, 田宮 浩之, 小島 康弘, 吉原 久直, 倉持 美知雄, 新井 秀宜, 田嶋 誠, 中野 純一, 長瀬 洋之, 山口 正雄, 立澤 直子, 佐川 俊世, 坂本 哲也, 鈴川 真穂, 田下 浩之, 大田 健
  • Organizer: 臨床アレルギー研究会
  • Place of Presentation: 東京
• [Presentation] 好酸球性気道炎症の基礎と臨床 肺における好酸球性炎症制御機構
  • Author(s): 鈴川 真穂, 蛇澤 晶, 庄司 俊輔, 大田 健, Broide David
  • Organizer: 日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] マウスにおけるSiglec-Fリガンドの発現パターンおよび好酸球性気道炎症に及ぼす作用
  • Author(s): 鈴川 真穂, Miller Marina, Rosenthal Peter, Cho Jae Youn, Doherty Taylor, Varki Ajit, Broide David, 大田 健
  • Organizer: 日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] Effect of siRNA inhibition of sialyltransferases and fucosyltransferases on Siglec-F ligand expression by epithelial cells in vitro
  • Author(s): Maho Suzukawa, Ken Ohta, and David Broide
  • Organizer: 2014 AAAAI Annual Meeting
  • Place of Presentation: San Diego
• [Presentation] Sialyltransferase ST3Gal-III plays an important role in Siglec-F ligand formation and eosinophilic lung inflammation in mice
  • Author(s): Maho Suzukawa, Marina Miller, Peter Rosenthal, Jae Youn Cho, Taylor Doherty, Ajit Varki, David Broide, Ken Ohta
  • Organizer: 日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Book] 連載「学会印象記」 第46回日本職業・環境アレルギー学会総会・学術大会. (2015)
  • Author(s): 鈴川真穂、大島信治.
  • Total Pages: 3
  • Publisher: 医薬ジャーナル社
• [Book] アレルギー性皮膚疾患が喘息に及ぼす影響. (2015)
  • Author(s): 鈴川真穂、大田健.
  • Total Pages: 5
  • Publisher: 科学評論社
• [Book] 肥満がフェノタイプに及ぼす意義. (2015)
  • Author(s): 鈴川真穂.
  • Total Pages: 6
  • Publisher: 医薬ジャーナル社
• [Book] 喘息の難治化因子 肥満. (2015)
  • Author(s): 鈴川真穂.
  • Total Pages: 5
  • Publisher: 先端医学社
• [Book] ブロンコレアとはどんな疾患でしょうか？ (2015)
  • Author(s): 鈴川真穂.
  • Total Pages: 1
  • Publisher: 北隆館
• [Book] 【喘息に影響する種々の側面とその課題をめぐって】 修飾因子の種々の側面を考慮した治療 肥満(解説/特集) (2014)
  • Author(s): 鈴川真穂
  • Total Pages: 5
  • Publisher: ライフ・サイエンス
• [Book] 【気管支喘息における新規生物学的製剤開発の可能性を探る】 IL-17(解説/特集) (2014)
  • Author(s): 鈴川真穂、中江進
  • Total Pages: 6
  • Publisher: 先端医学社
• [Book] Siglecによるアレルギーの抑制(解説) (2014)
  • Author(s): 鈴川真穂
  • Total Pages: 5
  • Publisher: 科学評論社
• [Book] 【アレルギー疾患と生物学的製剤】 標的分子の基礎医学的追求(解説/特集) (2014)
  • Author(s): 鈴川真穂、中江進
  • Total Pages: 4
  • Publisher: 北隆館
• [Book] 【難治性喘息 Up-Date―病態から治療まで】喘息の難治化因子 ― 肥満 (2014)
  • Author(s): 鈴川真穂
  • Total Pages: 5
  • Publisher: 先端医学社
• [Book] 【I型アレルギーを究める】 I型アレルギー診療の最近の動向 (2013)
  • Author(s): 鈴川 真穂, 大田 健
  • Total Pages: 6
  • Publisher: 医歯薬出版株式会社