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The involvement of mast cells in the development of lung fibrosis

Research Project

Project/Area Number 25461176
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKurume University

Principal Investigator

Kaieda Shinjiro  久留米大学, 医学部, 助教 (20330798)

Co-Investigator(Kenkyū-buntansha) Tomoaki Hoshino  久留米大学, 医学部, 教授 (00261066)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsMast cell / Myofibroblast / TGFβ / VEGF / mast cell / myofibroblast / fibroblast / smooth muscle actin / TGF / fibrosis / soluble factor
Outline of Final Research Achievements

We found that the expansion of mast cells in lung tissue obtained from idiopathic interstitial pneumonia patients. Mast cells are close proximity to fibroblast and myofibroblasts. We hypothezed that mast cells contribute to lung fibrosis via myofibroblast differentiation from pulmonary fibroblasts. In vitro coculture experiments, human mast cells did not induce fibrobrasts to myofibroblast differentiation. α-SMA mRNA expression was not upregulated during coculture with mast cells. However, mast cells activated fibroblasts to produce fibrogenic factors including TGF-β and VEGF. Amplification loop between mast cells and pulmonary fibroblasts were generated. Mast cells may be involved in the lung fibrosis via inducing pulmonary fibroblast activation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Mast cellと関節リウマチ2016

    • Author(s)
      海江田信二郎
    • Journal Title

      アレルギーの臨床

      Volume: 36 Pages: 44-47

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] IL-38: A New Factor in Rheumatoid Arthritis2015

    • Author(s)
      Shinjiro Kaieda
    • Organizer
      12th World Congress on Inflammation
    • Place of Presentation
      アメリカ合衆国 ボストン
    • Year and Date
      2015-08-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IL-38: A new factor in Rheumatoid Arthritis2015

    • Author(s)
      Shinjiro Kaieda
    • Organizer
      第59回日本リウマチ学会総会
    • Place of Presentation
      東京 高輪プリンスホテル
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] The inolvemnent of mast cells in the development of Lung Fibrosis2014

    • Author(s)
      Shinjiro Kaieda
    • Organizer
      日本リウマチ学会総会
    • Place of Presentation
      東京都品川区 高輪プリンスホテル
    • Year and Date
      2014-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] The Involvement of Mast cells in the Development of Lung Fibrosis2014

    • Author(s)
      Shinjiro Kaieda
    • Organizer
      日本リウマチ学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] The Involvement of Mast cells in the Development of Lung Fibrosis2013

    • Author(s)
      Shinjiro Kaieda
    • Organizer
      2013 annual meeting of American College of Rheumatology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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