The involvement of mast cells in the development of lung fibrosis
| Project/Area Number |
25461176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Tomoaki Hoshino 久留米大学, 医学部, 教授 (00261066)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Mast cell / Myofibroblast / TGFβ / VEGF / mast cell / myofibroblast / fibroblast / smooth muscle actin / TGF / fibrosis / soluble factor |
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| Outline of Final Research Achievements |
We found that the expansion of mast cells in lung tissue obtained from idiopathic interstitial pneumonia patients. Mast cells are close proximity to fibroblast and myofibroblasts. We hypothezed that mast cells contribute to lung fibrosis via myofibroblast differentiation from pulmonary fibroblasts. In vitro coculture experiments, human mast cells did not induce fibrobrasts to myofibroblast differentiation. α－SMA mRNA expression was not upregulated during coculture with mast cells. However, mast cells activated fibroblasts to produce fibrogenic factors including TGF-β and VEGF. Amplification loop between mast cells and pulmonary fibroblasts were generated. Mast cells may be involved in the lung fibrosis via inducing pulmonary fibroblast activation.
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Report
(4 results)
Research Products
(6 results)
