Study for pathological Analysis and clinical intervention of pulmonary MAC disease

• Project/Area Number: 25461178
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: Hoshino Yoshihiko 国立感染症研究所, その他部局等, その他 (20569694)
• Co-Investigator(Kenkyū-buntansha): Hasegawa Naoki 慶應義塾大学, 医学部 感染制御部, 教授 (20198724)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 抗酸菌 / 細胞性免疫 / 液性免疫 / ワクチン / 非結核性抗酸菌 / 抗酸菌感染 / インターフェロン

Outline of Final Research Achievements

Using Enzyme-Linked ImmunoSpot and Enzyme-Linked ImmunoSorbent Assays, we observed less correlation of both cellular medicated immunity and IgG titers with patient clinical status. However IgA titers were significantly correlated with clinical status, suggesting that specific IgA antibodies protect proliferation. In addition, in some cases, IgA antibody titers were significantly associated with the serum concentration of total albumin, which supports the idea that humoral immunity can be influenced by the nutritional status. Based on these observations, we propose that the induction of humoral immunity should be included as an option in vaccine development strategies.

Research Products

• [Journal Article] Epidemiology of Pulmonary Nontuberculous Mycobacterial Disease, Japan (2016)
  • Author(s): Ho Namkoong, Atsuyuki Kurashima, Kozo Morimoto, Yoshihiko Hoshino, Naoki Hasegawa, Manabu Ato, Satoshi Mitarai
  • Journal Title: Emerging Infectious Diseases Volume: 22 Pages: 1116-1117
  • Peer Reviewed / Open Access
• [Journal Article] Disseminated Mycobacterium marinum Infection With a Destructive Nasal Lesion Mimicking Extranodal NK/T Cell Lymphoma: A Case Report. (2016)
  • Author(s): ASAKURA T, ISHII M, KIKUCHI T, KAMEYAMA K, NAMKOONG H, NAKATA N, SUGITA K, TASAKA S, SHIMIZU T, HOSHINO Y, OKAMOTO S, BETSUYAKU T, HASEGAWA N.
  • Journal Title: Medicine (Baltimore) Volume: 95 Issue: 11 Pages: 3131-3131
  • DOI: 10.1097/md.0000000000003131
  • Peer Reviewed
• [Journal Article] Peptide-Based Immunotherapeutics and Vaccines 2015 (2015)
  • Author(s): Pedro A. Reche, Darren R. Flower, Masha Fridkis-Hareli, Yoshihiko Hoshino
  • Journal Title: Journal of Immunology Research Volume: 2015 Pages: 349049-349049
  • DOI: 10.1155/2015/349049
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nontuberculous Mycobacteriosis in Farmed Thread-sail Filefish <i>Stephanolepis cirrhifer</i> (2015)
  • Author(s): Hanako Fukano, Shinpei Wada, Osamu Kurata, Kaori Mizuno, Kazue Nakanaga, Yoshihiko Hoshino
  • Journal Title: Fish Pathology Volume: 50 Issue: 2 Pages: 68-74
  • DOI: 10.3147/jsfp.50.68
  • NAID: 130005085872
  • ISSN: 0388-788X, 1881-7335
  • Peer Reviewed
• [Journal Article] Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development. (2015)
  • Author(s): Niki M, Suzukawa M, Akashi S, Nagai H, Ohta K, Inoue M, Niki M, Kaneko Y, Morimoto K, Kurashima A, Kitada S, Matsumoto S, Suzuki K, Hoshino Y.
  • Journal Title: J Immunol Res Volume: 2015 Pages: 527395-527395
  • DOI: 10.1155/2015/527395
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differential diagnostic assays for discriminating mycobacteria, especially for nontuberculous mycobacteria: what does the future hold? (2015)
  • Author(s): Hoshino Y, Suzuki K.
  • Journal Title: Future Microbiology Volume: 10 Issue: 2 Pages: 205-216
  • DOI: 10.2217/fmb.14.120
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evaluation of humoral immunity to Mycobacterium tuberculosis-specific antigens for correlation with clinical status and effective vaccine development (2015)
  • Author(s): Mamiko Niki, Maho Suzukawa, Shunsuke Akashi, Hideaki Nagai, Ken Ohta, Manabu Inoue, Makoto Niki, Yukihiro Kaneko, Kozo Morimoto, Atsuyuki Kurashima, Seigo Kitada, Sohkichi Matsumoto, Koichi Suzuki, Yoshihiko Hoshino
  • Journal Title: Journal of Immunology Research Volume: xx
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Complete Genome Sequence and Comparative Genomic Analysis of Mycobacterium massiliense JCM 15300 in the Mycobacterium abscessus Group Reveal a Conserved Genomic Island MmGI-1 Related to Putative Lipid Metabolism (2014)
  • Author(s): Tsuyoshi Sekizuka, Masanori Kai, Kazue Nakanaga, Noboru Nakata, Yuko Kazumi, Shinji Maeda, Masahiko Makino, Yoshihiko Hoshino, Makoto Kuroda
  • Journal Title: PLoS ONE Volume: 9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A Molecular Typing Methodology of Mycobacterium tuberculosis using Small Genomic Islet Patterns (TB-SGIP): A Novel Genotyping Methodology to Discriminate Clinical Strains between Beijing Family and T3-OSAKA (2014)
  • Author(s): Tomoshige Matsumoto, Masahiro Suzuki, Yoshitsugu Iinuma, Shinji Maeda, Hiromi Ano, Yuriko Koshii, Tomomi Murakawa, Koichi Suzuki, Yoshihiko Hoshino
  • Journal Title: Journal of Infectious Diseases and Therapeutics Volume: 2 Issue: 2 Pages: 35-45
  • DOI: 10.14205/2310-9386.2014.02.02.2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Adenosine Deaminase Acting on RNA-1 (ADAR1) inhibits HIV-1 Replication in Human Alveolar Macrophages (2014)
  • Author(s): Michael D. Weiden, Satomi Hoshino, David N. Levy, Yonghua Li, Rajnish Kumar, Sean A. Burke, Rodney Dawson, Catarina E. Hioe, William Borkowsky, William N. Rom, Yoshihiko Hoshino
  • Journal Title: PLoS ONE Volume: 9 Issue: 10 Pages: e108476-e108476
  • DOI: 10.1371/journal.pone.0108476
  • Peer Reviewed / Open Access
• [Journal Article] Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria. (2014)
  • Author(s): Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-Hora M, Akashi K, Yamasaki S.
  • Journal Title: Immunity Volume: 41 Issue: 3 Pages: 402-13
  • DOI: 10.1016/j.immuni.2014.08.005
  • Peer Reviewed / Open Access
• [Journal Article] Nutritional Indicators are Correlated with the Radiological Severity Score in Patients with <i>Mycobacterium avium</i> Complex Pulmonary Disease: A Cross-sectional Study (2014)
  • Author(s): Morimoto K, Yoshiyama T, Kurashima A, Sasaki Y, Hoshino Y, Yoshimori K, Ogata H, Gemma A, Kudoh S, Y Shiraishi.
  • Journal Title: Internal Medicine Volume: 53 Issue: 5 Pages: 397-401
  • DOI: 10.2169/internalmedicine.53.1277
  • NAID: 130003392681
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Peptide-Based Immunotherapeutics and Vaccines (2014)
  • Author(s): Reche PA, Caldas EF, Flower DW, Fridkis-Hareli M, Hoshino Y
  • Journal Title: Journal of Immunology Research Volume: 2014 Pages: 256784-256784
  • DOI: 10.1155/2014/256784
  • Peer Reviewed
• [Journal Article] Immunological responses and epitope mapping by tuberculosis-associated antigens within the RD1 region in Japanese patients (2014)
  • Author(s): Nagai H, Suzukawa M, Sakakibara Y, Ohta K, Reche PA, Suzuki Kand Hoshino Y
  • Journal Title: Clinical and Developmental Immunology Volume: 2014 Pages: 764028-764028
  • DOI: 10.1155/2014/764028
  • Peer Reviewed
• [Journal Article] Discrimination of Mycobacterium abscessus subsp. massiliense from Mycobacterium abscessus subsp. abscessus in clinical isolates by multiplex PCR (2014)
  • Author(s): Nakanaga K, Sekizuka T, Fukano H, Sakakibara Y, Takeuchi F, Wada S, Ishii N, Makino M, Kuroda M, Hoshino Y
  • Journal Title: J Clin Microbiol Volume: 52 Issue: 1 Pages: 251-259
  • DOI: 10.1128/jcm.01327-13
  • Peer Reviewed
• [Journal Article] ntra-subspecies sequence variability of the MACPPE12 gene in Mycobacterium avium subsp. Hominissuis (2014)
  • Author(s): Iwamoto T, Arikawa K, Nakajima C, Nakanishi N, Nishiuchi Y, Yoshida S, Tamaru A,Tamura Y, Hoshino Y, Yoo H, Park YK, Saito H, Suzuki Y
  • Journal Title: Infect. Genet. Evolu. Volume: 21 Pages: 476-483
  • DOI: 10.1016/j.meegid.2013.08.010
  • Peer Reviewed / Open Access
• [Journal Article] Simultaneous and Longitudinal Comparison of Interferon Gamma Release Assays Among Health Care Workers in Japan. (2013)
  • Author(s): Matsumoto T, Hirayama Y, Hisamitsu Y, Fukumura M, Hirata A, Tanaka K, Kurokawa M, Tamura Y, Yoshida H, Nagai T, Kawase I, Suzuki S, Hoshino Y
  • Journal Title: Journal of Mycobacterial Disease Volume: 3 Issue: 03 Pages: 134-134
  • DOI: 10.4172/2161-1068.1000134
  • Peer Reviewed
• [Journal Article] C-Type lectin is an FcRr-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor (2013)
  • Author(s): Miyake Y, Ynmasaki S, et al.
  • Journal Title: Immunity Volume: 38 Issue: 5 Pages: 1050-62
  • DOI: 10.1016/j.immuni.2013.03.010
  • Peer Reviewed
• [Journal Article] A method for visual scoring of pulmonary Mycobacteirum avium complex disease: “NICE Scoring System” (2013)
  • Author(s): Kurashima A, Morimoto K, Horibe M, Hoshino Y, Shiraishi Y, Kudoh S
  • Journal Title: Journal of Mycobacterial Disease Volume: 3 Issue: 02 Pages: 127-127
  • DOI: 10.4172/2161-1068.1000127
  • Peer Reviewed
• [Journal Article] Buruli Ulcer and Mycolactone-Producing Mycobacteria (2013)
  • Author(s): Nakanaga K, Yotsu RR, Hoshino Y, Suzuki K, Makino M, Ishii1 N.
  • Journal Title: Japanese Journal of Infectious Diseases Volume: 66 Issue: 2 Pages: 83-88
  • DOI: 10.7883/yoken.66.83
  • NAID: 130003381664
  • ISSN: 1344-6304, 1884-2836
  • Peer Reviewed
• [Journal Article] Laboratory procedures for the detection and identification of cutaneous non-tuberculousmycobacterial infections (2013)
  • Author(s): Nakanaga K
  • Journal Title: The Journal of Dermatology Volume: 40 Issue: 3 Pages: 151-159
  • DOI: 10.1111/1346-8138.12047
  • Peer Reviewed
• [Presentation] 肺非結核性抗酸菌症，肺結核症，健常者における抗Interferon-γ自己抗体に関する検討 (2015)
  • Author(s): 青木 亜美、坂上 拓郎、島 賢治郎、青木 信将、茂呂 寛、田邊 嘉也、小屋 俊之、各務 博、成田 一衛、星野 仁彦、森本 耕三、倉島 篤行
  • Organizer: 第90回日本結核病学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2015-04-27
• [Presentation] Small genomic island の有無による新規結核菌遺伝子型別解析 TB-SGIPの開発 (2015)
  • Author(s): 松本 智成、 前田 伸司、星野 仁彦、倉島 篤行
  • Organizer: 第90回日本結核病学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2015-04-27
• [Presentation] 効果的なワクチン開発のための結核特異抗原に対する液性免疫の解析 (2015)
  • Author(s): 星野仁彦 仁木満美子、仁木 誠、金子幸弘 吉山崇、森本耕三、倉島篤行 後藤元、工藤翔二 永井英明、松本壮吉
  • Organizer: 第90回日本結核病学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2015-04-27
• [Presentation] 肺Mycobacterium scrofulaceum症の臨床的特徴 (2015)
  • Author(s): 鈴木 翔二、石井 誠、南宮 湖 八木 一馬、朝倉 崇徳、浅見 貴弘 田坂 定智 森野英里子、高崎 仁 石井 聡 上蓑 義典、藤原 宏、長谷川直樹 西村 知泰 星野 仁彦 倉島 篤行
  • Organizer: 第90回日本結核病学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2015-04-27
• [Presentation] 肺Mycobacterium lentiflavum症の3例の検討 (2015)
  • Author(s): 八木 一馬、石井 誠、南宮 湖 朝倉 崇徳、鈴木 翔二、浅見 貴弘 田坂 定智 森本 耕三、倉島 篤行 上簑 義典、藤原 宏、長谷川直樹
  • Organizer: 第90回日本結核病学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2015-04-27
• [Presentation] NTM症：罹患率増加の現状と今後の課題 (2015)
  • Author(s): 星野仁彦
  • Organizer: 第90回日本結核病学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2015-04-27
  • Invited
• [Presentation] 肺非結核性抗酸菌症，肺結核症，健常者における抗Interferon-γ自己抗体に関する検討 (2015)
  • Author(s): 青木 亜美、坂上 拓郎、島 賢治郎、青木 信将、茂呂 寛、田邊 嘉也、小屋 俊之、各務 博、成田 一衛、星野 仁彦、森本 耕三、倉島 篤行
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-17
• [Presentation] 本邦における肺非結核性抗酸菌症の疫学的実態に関する全国調査（第一報） (2015)
  • Author(s): 南宮 湖、倉島 篤行、森本 耕三、星野 仁彦、長谷川直樹、阿戸学、御手洗聡
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-17
• [Presentation] 結核特異抗原に対する液性免疫の解析 (2015)
  • Author(s): 星野仁彦 仁木満美子、鈴川真穂、赤司俊介、永井英明、大田健、森本耕三、倉島篤行、吉山崇、工藤翔二、松本壮吉
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-17
• [Presentation] Role of Dectin-2 in mycobacterial infection (2014)
  • Author(s): Akiko Yonekawa , Shinobu Saijo, Yoshihiko Hoshino, Yasunobu Miyake, Eri Ishikawa, Maho Suzukawa, Mitsutoshi Yoneyama, Masatsugu Oh-hora, Sho Yamasaki
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Characterization of a rapidly growing nontuberculous mycobacteria isolated from farmed thread-sail filefish Stephanolepis cirrhifer in Japan (2014)
  • Author(s): Hanako Fukano, Shinpei Wada, Osamu Kurata, Kaori Mizuno, Kazue Nakanaga, Yoshihiko Hoshino
  • Organizer: 9th Symposium on Diseases in Asian Aquaculture
  • Place of Presentation: Ho Chi Minh City (Vietnam)
  • Year and Date: 2014-11-24 – 2014-11-28
• [Presentation] ブルーリ潰瘍原因菌であるMycobacterium shinshuenseが持つ毒性脂質合成酵素coding plasmid pMUM001自然欠損変異株に対する全ゲノムシークエンス解析 (2014)
  • Author(s): 中永和枝、星野仁彦、大岡唯祐、小椋義俊、林哲也
  • Organizer: 文部科学省新学術領域「ゲノム支援」研究班拡大班会議
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2014-08-28 – 2014-08-29
• [Presentation] Clinical And Bacteriological Evaluations During Observation Of Mycobacterium Avium Complex Lung Disease Without Treatment (2014)
  • Author(s): Yoshifumi Kimizuka, Makoto Ishii, Yoshihiko Hoshino, Takahiro Asami, Tomoyasu, Nishimura, Shinji Maeda, Sadatomo Tasaka, Ho Namkoong, Hiroshi Fujiwara, Kazuma Yagi, Takayuki Abe, Satoshi Iwata, Tomoko Betsuyaku, Naoki Hasegawa :Non-Tuberculous Mycobacteriosis Tokyo Research Consortium (NTM-TRC)
  • Organizer: The 109th International Conference of American Thoracic Society
  • Place of Presentation: SAN DIEGO (USA)
  • Year and Date: 2014-05-16 – 2014-05-21
• [Presentation] Grasping The Environmental Exposure Of The Patients With Pulmonary Nontuberculous Mycobacterial Disease Using Questionnaire Survey In Japan (2014)
  • Author(s): Kozo Morimoto, Kazuhiro Uchimura, Yuka Sasaki, Yoshihiko Hoshino, Takashi Yoshiyama, Hideo Ogata, Atsuyuki Kurashima, Shoji Kudoh, Ryozo Yano
  • Organizer: The 109th International Conference of American Thoracic Society
  • Place of Presentation: SAN DIEGO (USA)
  • Year and Date: 2014-05-16 – 2014-05-21
• [Presentation] アンケートを用いた肺NTM症患者の環境暴露把握調査 (2014)
  • Author(s): 森本耕三、吉山崇、内村和弘、佐々木結花、倉島篤行、星野仁彦、御手洗聡、尾形英雄、早乙女幹朗、上山雅子、工藤翔二
  • Organizer: 第89回日本結核病学会総会
  • Place of Presentation: 岐阜県 長良川国際会議場
  • Year and Date: 2014-05-09 – 2014-05-10
• [Presentation] 肺Mycobacterium avium complex症に対するアミカシン投与例の検討(後ろ向き他施設共同研究) (2014)
  • Author(s): 南宮湖、森本耕三、西村知泰、八木一馬、浅見貴弘、船津洋平、藤原宏、君塚善文、石井誠、田坂定智、星野仁彦、長谷川 直樹、倉島篤行
  • Organizer: 第89回日本結核病学会総会
  • Place of Presentation: 岐阜県 長良川国際会議場
  • Year and Date: 2014-05-09 – 2014-05-10
• [Presentation] 肺Mycobacterium abscessus症に対するアミカシン投与例の検討(後ろ向き他施設共同研究) (2014)
  • Author(s): 南宮湖、森本耕三、西村知泰、八木一馬、浅見貴弘、船津洋平、藤原宏、君塚善文、石井誠、田坂定智、星野仁彦、長谷川 直樹、倉島篤行
  • Organizer: 第89回日本結核病学会総会
  • Place of Presentation: 岐阜県 長良川国際会議場
  • Year and Date: 2014-05-09 – 2014-05-10
• [Presentation] 当院における肺Mycobacterium abscessus complex症の検討 (2014)
  • Author(s): 浅見貴弘、石井誠、八木一馬、南宮湖、船津洋平、藤原宏、君塚善文、西村知泰、斎藤史武、田坂定智、星野仁彦、別役智子、長谷川 直樹
  • Organizer: 第89回日本結核病学会総会
  • Place of Presentation: 岐阜県 長良川国際会議場
  • Year and Date: 2014-05-09 – 2014-05-10
• [Presentation] 肺MAC症における無治療経過観察群の増悪治療開始に関する後ろ向き検討 (2014)
  • Author(s): 星野仁彦、君塚善文、浅見貴弘、西村知泰、田坂 定智、石井誠、南宮湖、藤原宏、船津洋平、前田 伸司、岩田敏、森本耕三、倉島篤行、長谷川 直樹
  • Organizer: 第89回日本結核病学会総会
  • Place of Presentation: 岐阜県 長良川国際会議場
  • Year and Date: 2014-05-09 – 2014-05-10
• [Presentation] 抗酸菌の遺伝子解析分野 (2014)
  • Author(s): 星野仁彦
  • Organizer: 第89回日本結核病学会総会
  • Place of Presentation: 岐阜県 長良川国際会議場
  • Year and Date: 2014-05-09 – 2014-05-10
  • Invited
• [Presentation] NTM症の免疫学 (2014)
  • Author(s): 星野仁彦
  • Organizer: 第89回日本結核病学会総会
  • Place of Presentation: 岐阜県 長良川国際会議場
  • Year and Date: 2014-05-09 – 2014-05-10
  • Invited
• [Presentation] 無治療経過観察を受けた肺Mycobcateirum avium complex症患者の臨床的及び細菌学的検討 (2014)
  • Author(s): 君塚善文、長谷川直樹、星野仁彦、石井誠、西村知泰、浅見貴弘、田坂定智、南宮湖、藤原宏、船津洋平、八木一馬、阿部貴行、前田伸司、岩田敏、別役智子
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] Dectin-2は抗酸菌のlipogylcanと結合して抗原性を増強する (2014)
  • Author(s): 星野仁彦、米川晶子、西城忍、井上博雅、山崎晶
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] Usefulness Of Biomarkers (Glycopeptidolipid Core IgA Antibody, CD64 On Neutrophils, Cathelicidin, And Vitamin D) And Radiologic Score (NICE Score) In MAC Pulmonary Disease (2013)
  • Author(s): Morimoto K, Hoshino Y, Sasaki Y, Yoshiyama T, Sakakibara Y, Ogata H, Kudoh S, Kurashima A
  • Organizer: The 108th International Conference of American Thoracic Society
  • Place of Presentation: San Diego, USA
• [Presentation] Gene expression analysis of 40-years’ hypoxic culture of Mycobacterium tuberculosis. (2013)
  • Author(s): Satoshi Mitarai, Yoshihiko Hoshino, Tomoko Kato, Akio Aono, Kinuyo Chikamatsu, Hiroyuki Yamada
  • Organizer: 44th Union World Conference on Lung Health
  • Place of Presentation: Paris, France
• [Book] 肺MAC症診療Up to Date (2013)
  • Author(s): 倉島篤行 小川賢二編集
  • Total Pages: 272
  • Publisher: 南江堂