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Development of a novel diagnostic system using next-generation sequencing for targetable gene alterations in lung cancer

Research Project

Project/Area Number 25461179
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNational Cancer Center Japan

Principal Investigator

MATSUMOTO SHINGO  国立研究開発法人国立がん研究センター, 先端医療開発センター, 医員 (10392341)

Co-Investigator(Renkei-kenkyūsha) TSUCHIHARA KATSUYA  独立行政法人国立がん研究センター, 先端医療開発センター, 分野長 (00415514)
OHE YUICHIRO  独立行政法人国立がん研究センター, 中央病院, 副院長 (20233041)
GOTO KOICHI  独立行政法人国立がん研究センター, 東病院, 科長 (90435719)
KOHNO TAKASHI  独立行政法人国立がん研究センター, 研究所, 分野長 (80280783)
KATOH MAMORU  独立行政法人国立がん研究センター, 研究所, 研究員 (40391916)
Research Collaborator SUGIYAMA ERI  独立行政法人国立がん研究センター, 先端医療開発センター, 外来研究員 (50775385)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords肺がん / マルチプレックス遺伝子診断 / 次世代シークエンス / NGS診断 / 融合遺伝子 / 肺癌 / ドライバー遺伝子 / マルチプレックス診断 / ターゲットシーケンス / 分子標的治療 / 遺伝子診断 / ターゲットキャプチャー / シークエンス
Outline of Final Research Achievements

Establishment of a multiplex gene diagnostics is necessary for the development of precision medicine in lung cancer. We have generated a novel multiplex gene diagnostics by next-generation sequencing technology with a target enrichment system capturing genomic DNA. A variety of targetable gene alterations such as gene mutations and fusions occurring in lung cancer were successfully detected by our sequencing system. The detection sensitivity of targetable gene alterations by our diagnostic method was revealed to be more than 5% of cancer-derived genomic DNA. Further examination and evaluation for the clinical validity and utility are needed to establish this diagnostics. Additionally, the application of this method to gene diagnoses with peripheral blood samples; i.e., liquid biopsy, is an important issue to be essentially addressed.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2015 2013

All Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Mutational profile of targetable oncogenes in younger adult patients with lung adenocarcinoma2015

    • Author(s)
      Eri Sugiyama
    • Organizer
      ECCO/ESMO 2015 Congress
    • Place of Presentation
      Austria
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prevalence of driver gene alterations in younger adult patients with lung adenocarcinoma2015

    • Author(s)
      杉山 栄里
    • Organizer
      第13回日本臨床腫瘍学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Establishment of a diagnostic system using next-generation sequencing for RET rearrangements2013

    • Author(s)
      松本慎吾
    • Organizer
      The European Cancer Congress 2013
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2013 Research-status Report
  • [Presentation] Establishment of a diagnostic system using next generation sequencing for ALK, RET and ROS1 rearrangements in NSCLC2013

    • Author(s)
      松本慎吾
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] ゲノムシークエンスによるALK/RET/ROS1融合遺伝子診断法の開発2013

    • Author(s)
      松本慎吾
    • Organizer
      第54回日本肺癌学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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