The role of proteasome in pulmonary fibrosis

• Project/Area Number: 25461181
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: Nagai Katsura 北海道大学, 医学(系)研究科(研究院), 客員研究員 (40374293)
• Co-Investigator(Kenkyū-buntansha): TOMARU Utano 北海道大学, 医学研究科(研究院), 准教授 (20360901)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: プロテアソーム / 間質性肺炎

Outline of Final Research Achievements

The activity of 20S proteasome in bronchoalveolar labage fluid tend to be higher in the patients with idiopathic pulmonary fibrosis (IPF) than normal subjects or sarcoidosis patients. Increased proteasome activity suggests a link to fibrotic reaction. In contrast, cigarette smoke-exposed Tg mice with decreased proteasomal chymotrypsin-like activity showed remarkable air space enlargement and increased apoptotic cells compared with wild type controls. Impaired proteasomal activity also enhanced apoptosis and endoplasmic reticulum stress in cigarette smoke extract (CSE)-exposed fibroblastic cells.

Research Products

• [Journal Article] The responses of macrophages in interaction with neutrophils that undergo NETosis (2016)
  • Author(s): Nakazawa D, Shida H, Kusunoki Y, Miyoshi A, Nishio S, Tomaru U, Atsumi T, Ishizu A
  • Journal Title: J Autoimmun Volume: Feb;67 Pages: 19-28
  • DOI: 10.1016/j.jaut.2015.08.018
  • NAID: 120005743065
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel monoclonal antibodies that recognize both rat and mouse phosphatidylserine/prothrombin complexes. (2016)
  • Author(s): Kawakami T, Yoon SY, Takeuchi S, Soma Y, Kuroha S, Yoshida S, Shida H, Nakazawa D, Tomaru U, Ishizu A.
  • Journal Title: Mod Rheumatol. Volume: 26(3) Issue: 3 Pages: 470-471
  • DOI: 10.3109/14397595.2015.1054090
  • NAID: 120006219908
  • Peer Reviewed
• [Journal Article] Distinct Phenotypes of Cigarette Smokers Identified by Cluster Analysis of Patients with Severe Asthma (2015)
  • Author(s): Konno S, Taniguchi N, Makita H, Nakamaru Y, Shimizu K, Shijubo N, Fuke S, Takeyabu K, Oguri M, Kimura H, Maeda Y, Suzuki M, Nagai K, Ito YM, Wenzel SE, Nishimura M
  • Journal Title: Ann Am Thorac Soc Volume: 12 Issue: 12 Pages: 1771-1780
  • DOI: 10.1513/annalsats.201507-407oc
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Decreased proteosomal function accelerates cigarette smoke-induced pulmonary emphysema in mice. (2015)
  • Author(s): Yamada Y, Tomaru U, Ishizu A, Ito T, Kiuchi T, Ono A, Miyajima S, Nagai K, Higashi T, Matsuno Y, Dosaka-Akita H, Nishimura M, Miwa S, Kasahara M
  • Journal Title: Lab Invest Volume: 95 Issue: 6 Pages: 625-634
  • DOI: 10.1038/labinvest.2015.43
  • Peer Reviewed
• [Journal Article] Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients (2015)
  • Author(s): Nagai K, Makita H, Suzuki M, Shimizu K, Konno S, Ito YM, Nishimura M
  • Journal Title: Int J COPD Volume: 10 Pages: 745-757
  • DOI: 10.2147/copd.s77586
  • NAID: 120005613572
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Temporal Changes in Glutaredoxin 1 and Protein S-Glutathionylation in Allergic Airway Inflammation. (2015)
  • Author(s): Maki K, Nagai K, Suzuki M, Inomata T, Yoshida T, Nishimura M.
  • Journal Title: PLoS One Volume: 10 Issue: 4 Pages: e0122986-e0122986
  • DOI: 10.1371/journal.pone.0122986
  • NAID: 120005611268
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regional bronchodilator response assessed by computed tomographyin chronic obstructive pulmonary disease (2015)
  • Author(s): Shimizu K, Makita H, Hasegawa M, Kimura H, Fuke S, Nagai K, Yoshida T, Suzuki M, Konno S, Ito Y, ,Nishimura M
  • Journal Title: European Journal of Radiology Volume: 10 Issue: 6 Pages: 1196-1201
  • DOI: 10.1016/j.ejrad.2015.02.022
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Impact of c-Fos/Activator Protein-1 Inhibition on Allogeneic Pancreatic Islet Transplantation. (2015)
  • Author(s): Yoshida T, Yamashita K, Watanabe M, Koshizuka Y, Kuraya D, Ogura M, Asahi Y, Ono H, Emoto S, Mizukami T, Kobayashi N, Shibasaki S, Tomaru U, Kamachi H, Matsushita M, Shiozawa S, Hirono S, Todo S.
  • Journal Title: Am J Transplant. Volume: 15(10) Issue: 10 Pages: 2565-2575
  • DOI: 10.1111/ajt.13338
  • Peer Reviewed / Open Access
• [Journal Article] Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers (2015)
  • Author(s): Honma R, Kinoshita I, Miyoshi E, Tomaru U, Matsuno Y, Shimizu Y, Takeuchi S, Kobayashi Y, Kaga K, Taniguchi N, Dosaka-Akita H
  • Journal Title: Oncology Volume: 88 Issue: 5 Pages: 298-305
  • DOI: 10.1159/000369495
  • Peer Reviewed
• [Journal Article] Decreased expression of thymus-specific proteasome subunit β5t in Down syndrome patients. (2015)
  • Author(s): Tomaru U, Tsuji T, Kiuchi S, Ishizu A, Suzuki A, Otsuka N, Ito T, Ikeda H, Fukasawa Y, Kasahara M.
  • Journal Title: Histopathology. Volume: なし Issue: 2 Pages: 235-244
  • DOI: 10.1111/his.12642
  • Peer Reviewed
• [Journal Article] Presence of autoimmune regulator and absence of desmoglein 1 in thymoma associated with a pemphigus foliaceus patient. (2015)
  • Author(s): Tsuchisaka, A.
  • Journal Title: Br. J. Dermatol. Volume: 印刷中 Issue: 1 Pages: 268-271
  • DOI: 10.1111/bjd.13617
  • Peer Reviewed
• [Journal Article] Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers. (2015)
  • Author(s): Honma R, Kinoshita I, Miyoshi E, Tomaru U, Matsuno Y, Shimizu Y, Takeuchi S, Kobayashi Y, Kaga K, Taniguchi N, Dosaka-Akita H.
  • Journal Title: Oncology. Volume: 173 Pages: 268-71
  • Peer Reviewed
• [Journal Article] Decreased proteasomal function accelerates cigarette smoke-induced pulmonary emphysema in mice (2015)
  • Author(s): Yamada Y, Tomaru U, Ishizu A , Ito T, Kiuchi T, Ono A, Miyajima S, Nagai K, Higashi T, Matsuno Y, Dosaka-Akita H, Nishimura M, Miwa S, Kasahara M
  • Journal Title: Lab Invest Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Establishment of a vascular endothelial cell-reactive type II NKT cell clone from a rat model of autoimmune vasculitis. (2015)
  • Author(s): Iinuma C, Waki M, Kawakami A, Yamaguchi M, Tomaru U, Sasaki N, Masuda S, Matsui Y, Iwasaki S, Baba T, Kasahara M, Yoshiki T, Paletta D, Herrmann T, Ishizu A.
  • Journal Title: Int Immunol. Volume: 27 Issue: 2 Pages: 105-114
  • DOI: 10.1093/intimm/dxu088
  • Peer Reviewed
• [Journal Article] Lower leptin/adiponectin ratio and risk of rapid lung function decline in chronic obstructive pulmonary disease (2014)
  • Author(s): Suzuki M
  • Journal Title: Ann Am Thorac Soc Volume: 11 Issue: 10 Pages: 1511-9
  • DOI: 10.1513/annalsats.201408-351oc
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet. (2014)
  • Author(s): Matsui Y, Tomaru U, Miyoshi A, Ito T, Fukaya S, Miyoshi H, Atsumi T, Ishizu A.
  • Journal Title: Exp Mol Pathol. Volume: 97(3) Issue: 3 Pages: 354-358
  • DOI: 10.1016/j.yexmp.2014.09.017
  • NAID: 120005476093
  • Peer Reviewed
• [Journal Article] Decreased proteasomal activity causes photoreceptor degeneration in mice. (2014)
  • Author(s): Ando R, Noda K, Tomaru U, Kamoshita M, Ozawa Y, Notomi S, Hisatomi T, Noda M, Kanda A, Ishibashi T, Kasahara M, Ishida S.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 55 Issue: 7 Pages: 4682-4690
  • DOI: 10.1167/iovs.13-13272
  • Peer Reviewed / Open Access
• [Journal Article] HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells. (2014)
  • Author(s): Araya N, Sato T, Ando H, Tomaru U, Yoshida M, Coler-Reilly A, Yagishita N, Yamauchi J, Hasegawa A, Kannagi M, Hasegawa Y, Takahashi K, Kunitomo Y, Tanaka Y, Nakajima T, Nishioka K, Utsunomiya A, Jacobson S, Yamano Y.
  • Journal Title: J Clin Invest. Volume: 124 Issue: 8 Pages: 3431-42
  • DOI: 10.1172/jci75250
  • Peer Reviewed / Open Access
• [Journal Article] Enhanced formation and disordered regulation of NETs in MPO-ANCA-associated microscopic polyangiitis (2014)
  • Author(s): Nakazawa D, Shida H, Tomaru U, Yoshida M, Nishio S, Atsumi T, Ishizu A.
  • Journal Title: Journal of the American Society of Nephrology Volume: Epub Issue: 5 Pages: 990-997
  • DOI: 10.1681/asn.2013060606
  • Peer Reviewed / Open Access
• [Journal Article] Ag and IL-2 immune complexes efficiently expand Ag-specific Treg cells that migrate in response to chemokines and reduce localized immune responses. (2014)
  • Author(s): Hamano R, Baba T, Sasaki S, Tomaru U, Ishizu A, Kawano M, Yamagishi M, Mukaida N
  • Journal Title: Eur J Immunol Volume: 44 Issue: 4 Pages: 1005-1015
  • DOI: 10.1002/eji.201343434
  • Peer Reviewed / Open Access
• [Journal Article] Effect of lung volume on airway luminal area assessed by computed tomography in chronic obstructive pulmonary disease. (2014)
  • Author(s): Kambara K
  • Journal Title: PLoS One Volume: 28 Issue: 2 Pages: e90040-e90040
  • DOI: 10.1371/journal.pone.0090040
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Relationship between neutrophil influx and oxidative stress in alveolar space in lipopolysaccharide-induced lung injury. (2014)
  • Author(s): Yoshida T, Nagai K, Inomata T, Ito Y, Betsuyaku T, Nishimura M.
  • Journal Title: Respir Physiol Neurobiol Volume: １９１ Pages: 75-83
  • DOI: 10.1016/j.resp.2013.11.008
  • Peer Reviewed
• [Journal Article] Clinical features and determinants of COPD exacerbation in the Hokkaido COPD cohort study. (2014)
  • Author(s): Suzuki M, Makita H, Ito YM, Nagai K, Konno S, Nishimura M; for the Hokkaido COPD Cohort Study Investigators.
  • Journal Title: Eur Respir J. Volume: 43 Pages: 1289-97
  • Peer Reviewed
• [Journal Article] Corticomedullary differentiation and maturational arrest in thymomas. (2014)
  • Author(s): Storbel P, Hartmann E, Rosenwald A, Kalla J, Ott G, Schalke B, Kasahara M, Tomaru U, Marx A.
  • Journal Title: Histopathology Volume: 64 Issue: 4 Pages: 557-566
  • DOI: 10.1111/his.12279
  • Peer Reviewed
• [Journal Article] Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis. (2014)
  • Author(s): Sato T, Yamano Y, Tomaru U, Shimizu Y, Ando H, Okazaki T, Nagafuchi H, Shimizu J, Ozaki S, Miyazawa T, Yudoh K, Oka H, Suzuki N.
  • Journal Title: Mod Rheumatol Volume: 24(1) Issue: 1 Pages: 129-136
  • DOI: 10.3109/14397595.2013.852854
  • Peer Reviewed
• [Journal Article] Expression of thymoproteasome subunit β5t in type AB thymoma. (2014)
  • Author(s): Yamada Y, Tomaru U, Ishizu A, Kiuchi T, Kasahara M, Matsuno Y.
  • Journal Title: J Clin Pathol. Volume: 67 Issue: 3 Pages: 276-278
  • DOI: 10.1136/jclinpath-2013-201930
  • Peer Reviewed
• [Journal Article] Possible linkage between microscopic polyangiitis and thrombosis via neutrophil extracellular traps. (2014)
  • Author(s): Imamoto T, Nakazawa D, Shida H, Suzuki A, Otsuka N, Tomaru U, Ishizu A.
  • Journal Title: Clin Exp Rheumatol Volume: 32 Pages: 149-50
  • NAID: 120005397871
  • Peer Reviewed
• [Journal Article] Enhanced Formation and Disordered Regulation of NETs in Myeloperoxidase-ANCA-Associated Microscopic Polyangiitis. (2014)
  • Author(s): Nakazawa D, Shida H, Tomaru U, Yoshida M, Nishio S, Atsumi T, Ishizu A.
  • Journal Title: J Am Soc Nephrol. Volume: 未定
  • NAID: 120005372312
  • Peer Reviewed
• [Journal Article] Thymoproteasome: roles in thymic selection and clinical applications as a diagnostic marker of thymic epithelial tumors. (2013)
  • Author(s): Tomaru, U.
  • Journal Title: Arch. Immunol. Ther. Exp. Volume: 61 Issue: 5 Pages: 357-365
  • DOI: 10.1007/s00005-013-0234-1
  • Peer Reviewed
• [Journal Article] Human papillomavirus 16-positive uterine cervical squamous cell carcinoma with coinfection with human papillomavirus 34 has a lower incidence in lymph node metastasis than that without coinfection with human papillomavirus 34. (2013)
  • Author(s): Michimata R, Watari H, Tomaru U, Sakuragi N, Ishizu A.
  • Journal Title: Pathobiology Volume: 80(5) Issue: 5 Pages: 259-264
  • DOI: 10.1159/000350423
  • NAID: 120005311820
  • Peer Reviewed
• [Journal Article] Prediction of response to treatment by gene expression profiling of peripheral blood in patients with microscopic polyangiitis. (2013)
  • Author(s): Ishizu A, Tomaru U, Murai T, Yamamoto T, Atsumi T, Yoshiki T, Yumura W, Yamagata K, Yamada H, Kumagai S, Kurokawa MS, Suka M, Makino H, Ozaki S.
  • Journal Title: PLOS ONE Volume: 8 Issue: 5 Pages: e63182-e63182
  • DOI: 10.1371/journal.pone.0063182
  • Peer Reviewed
• [Journal Article] Lysosomal-associated membrane protein-2 plays an important role in the pathogenesis of primary cutaneous vasculitis. (2013)
  • Author(s): Takeuchi S, Kimura S, Soma Y, Waki M, Yamaguchi M, Nakazawa D, Tomaru U, Ishizu A, Kawakami T
  • Journal Title: Rheumatology Volume: 52 Issue: 9 Pages: 1592-1598
  • DOI: 10.1093/rheumatology/ket159
  • Peer Reviewed
• [Journal Article] [Successful rituximab treatment for acquired amegakaryocytic thrombocytopenic purpura complicated with Coombs-negative autoimmune hemolytic anemia]. (2013)
  • Author(s): Hashimoto A, Fujimi A, Kanisawa Y, Matsuno T, Okuda T, Minami S, Doi T, Ishikawa K, Uemura N, Tomaru U.
  • Journal Title: Rinsho Ketsueki Volume: 54 Pages: 568-73
  • NAID: 10031185458
  • Peer Reviewed
• [Journal Article] Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy. (2013)
  • Author(s): Ando H., Sato T., Tomaru U., Yoshida M., Utsunomiya A., Yamauchi J., Araya N., Yagishita N., Coler-Reilly A., Shimizu Y., Yudoh K., Hasegawa Y., Nishioka K., Nakajima T., Jacobson S., Yamano Y.
  • Journal Title: Brain Volume: 136(Pt9) Issue: 9 Pages: 2876-2887
  • DOI: 10.1093/brain/awt183
  • Peer Reviewed
• [Journal Article] Possible implication of Fcγ receptor-mediated trogocytosis in susceptibility to systemic autoimmune disease. (2013)
  • Author(s): Masuda S, Iwasaki S, Tomaru U, Baba T, Katsumata K, Ishizu A
  • Journal Title: Clin Dev Immunol Volume: 2013 Pages: 345745-345745
  • DOI: 10.1155/2013/345745
  • Peer Reviewed
• [Presentation] Aberrant expression of proteasomes affects thymic T cell selection． (2015)
  • Author(s): Syota Miyajima, Utano Tomaru，Akihiro Ishizu, Shizuka Kiuchi and Masanori Kasahara
  • Organizer: 第44回日本免疫学会総会
  • Place of Presentation: 札幌コンベンションセンター（北海道・札幌市）
  • Year and Date: 2015-11-18
• [Presentation] 胸腺T細胞選択におけるプロテアソームキモトリプシン様活性サブユニットの役割． (2015)
  • Author(s): 宮島祥太，外丸詩野，石津明洋，木内静香，大井智貴，笠原正典
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2015-04-30
• [Presentation] プロテアソーム機能低下マウスにおける記銘力障害の解析． (2015)
  • Author(s): 伊藤智樹，外丸詩野，大村優，戸松留花，石津明洋，笠原正典
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2015-04-30
• [Presentation] ダウン症患者の胸腺におけるプロテアソームサブユニットβ5tの発現低下 (2015)
  • Author(s): 木内静香，外丸詩野，辻隆裕，石津明洋，鈴木昭，大塚紀幸，伊藤智樹，池田仁，深澤雄一郎，笠原正典
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2015-04-30
• [Presentation] ダウン症患者の胸腺におけるプロテアソームサブユニットβ５ｔの発現低下 (2015)
  • Author(s): ）木内静香、外丸詩野、辻 隆裕、石津明洋、鈴木 昭、大塚紀幸、伊藤智樹、池田 仁、深澤雄一郎、笠原正典
  • Organizer: 第34回日本胸腺研究会
  • Place of Presentation: ユニコムプラザさがみはら（神奈川県・相模原市）
  • Year and Date: 2015-02-07
• [Presentation] Aberrant expression of proteasomal β5 subunit affects T cell repertories in the thymus. (2014)
  • Author(s): Shizuka Kikuchi, Utano Tomaru, Saori Konno, Shota Miyajima, Akihiro Ishizu, Masanori Kasahara
  • Organizer: 第43回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館（京都府・京都市）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] 高血糖による好中球細胞トラップ（neutrophil extracellular traps;NETs）の形成亢進 (2014)
  • Author(s): 三次有奈、山田真衣、館山ゆう、楠由宏、志田玄貴、中沢大悟、外丸詩野、三好秀明、渥美達也、石津明洋
  • Organizer: 第47回北海道病理談話会
  • Place of Presentation: 旭川グランドホテル（北海道・旭川市）
  • Year and Date: 2014-10-11
• [Presentation] 抗ラクトフェリン抗体の病原性 (2014)
  • Author(s): 志田玄貴、中沢大悟、館山ゆう、楠由宏、三次有奈、外丸詩野、渥美達也、石津明洋
  • Organizer: 第47回北海道病理談話会
  • Place of Presentation: 旭川グランドホテル（北海道・旭川市）
  • Year and Date: 2014-10-11
• [Presentation] プロテアソーム機能低下モデルマウスにおける脳機能障害の解析 (2014)
  • Author(s): 伊藤智樹、外丸詩野、大村優、戸松留花、石津明洋、笠原正典
  • Organizer: 第47回北海道病理談話会
  • Place of Presentation: 旭川グランドホテル（北海道・旭川市）
  • Year and Date: 2014-10-11
• [Presentation] Differential changes in quality of life components over 5 years in adequately treated patients with COPD in Hokkaido COPD cohort study (2014)
  • Author(s): Katsura Nagai,Hironi Makita,Masaru Suzuki,Kaoruko Shimizu,Satoshi Konno, Masaharu Nishimura,The Hokkaido COPD cohort study investigators
  • Organizer: 東京アジアCOPDシンポジウム2014
  • Place of Presentation: 経団連会館（東京都）
  • Year and Date: 2014-07-05
• [Presentation] Lower Plasma Leptin/Adiponectin Ratio Predicts Lung Function Decline In Patients With Chronic Obstructive Pulmonary Disease: An Analysis Of Data From Two Prospective Cohort Studies (2014)
  • Author(s): Masaru Suzuki, Hironi Makita, Jorgen Ostling, Laura H. Thomsen , Satoshi Konno , Katsura Nagai , Kaoruko Shimizu, Asger Dirksen, Rose A. Maciewicz, Masaharu Nishimura,
  • Organizer: Annals of the American Thoracic Society meeting, 2014
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-05-18 – 2014-05-21
• [Presentation] Emphysema And Airways Assessed By Computed Tomography In COPD Patients Who Displayed Variable Annual Changes In FEV1 Over 5 Years (2014)
  • Author(s): Kaoruko Shimizu, Hironi Makita, Masaru Suzuki, Katsura Nagai, Satoshi Konno, Nguyen V. Tho, Emiko Ogawa, Yasutaka Nakano, Masaharu Nishimura
  • Organizer: Annals of the American Thoracic Society meeting, 2014
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-05-18 – 2014-05-21
• [Presentation] Neutrophil-, But Not Lymphocyte-, Predominant Inflammation Is Associated With Local Progression Of Nontuberculous Mycobacterium (NTM) Infection (2014)
  • Author(s): Takashi Inomata , Satoshi Konno, Katsura Nagai, Masaharu Nishimura
  • Organizer: Annals of the American Thoracic Society meeting, 2014
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-05-18 – 2014-05-21
• [Presentation] Associations Of Serum Periostin Level With Sinusitis Severity And Persistent Airflow Limitation In Severe Asthma (2014)
  • Author(s): Hirokazu Kimura, Satoshi Konno, Yuji Nakamaru, Hironi Makita, Natsuko Taniguchi, Kaoruko Shimizu, Yukiko Maeda, Masaru Suzuki, Katsura Nagai, Junya Ono, Kenji Izuhara, Masaharu Nishimura
  • Organizer: Annals of the American Thoracic Society meeting, 2014
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-05-18 – 2014-05-21
• [Presentation] Glutaredoxin Regulates Chemokine Expression Induced By IL-13 And TNF-α (2014)
  • Author(s): Kanako Maki, Katsura Nagai, Masaru Suzuki, Takashi Inomata, Masaharu Nishimura
  • Organizer: Annals of the American Thoracic Society meeting, 2014
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-05-18 – 2014-05-21
• [Presentation] Role Of Apoptosis Inhibitor Of Macrophage (AIM) In LPS-Induced Lung Injury (2014)
  • Author(s): Hiroki Kimura, Masaru Suzuki, Katsura Nagai, Takahide Nagase, Toru Miyazaki, Masaharu Nishimura,
  • Organizer: Annals of the American Thoracic Society meeting, 2014
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-05-18 – 2014-05-21
• [Presentation] Elevated Plasma Adiponectin Associated With Lung Function Decline In Patients With Chronic Obstructive Pulmonary Disease (2014)
  • Author(s): Masaru Suzuki, Hironi Makita, Jorgen Ostling, Satoshi Konno, Katsura Nagai, Kaoruko Shimizu, Rose A. Maciewicz, Masaharu Nishimura
  • Organizer: Annals of the American Thoracic Society meeting, 2014
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-05-18 – 2014-05-21
• [Presentation] 当院における喀痰トリコスポロン陽性症例の臨床的特徴の検討 (2014)
  • Author(s): 武井 望長井 桂猪又 崇志渋江 寧谷口 菜津子 清水 薫子鈴木 雅今野 哲西村 正治
  • Organizer: 第54回 日本呼吸器学会学術講演会
  • Place of Presentation: 大阪国際会議場（大阪府・大阪市）
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] 胸腺におけるプロテアソームキモトリプシン様活性サブユニットの発現とT細胞選択 (2014)
  • Author(s): 木内静香、外丸詩野、石津明洋、宮島祥太、平川彩香、笠原正典
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: ANAクラウンプラザ（広島県・広島市）
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] プロテアソーム機能異常と脳機能の低下 (2014)
  • Author(s): 伊藤智樹、外丸詩野、大村優、石津明洋、笠原正典
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: ANAクラウンプラザ（広島県・広島市）
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 高齢男性でみられたEBV陽性肝脾腫γδT細胞リンパ腫の一例 (2014)
  • Author(s): 竹中淳規、大塚紀幸、藤田裕美、中馬誠、外丸詩野、石津明洋、笠原正典
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: ANAクラウンプラザ（広島県・広島市）
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] Relationship of Baseline or Annual Change of Clinical Parameters on Mortality in patients with COPD (2013)
  • Author(s): Makita H, Suzuki M, Nagai K, Nishimura M
  • Organizer: the European Respiratory Society's 23rd Annual Congress
  • Place of Presentation: Fira Barcelona(Spain)
• [Presentation] Relationships between glutaredoxin 1 and cytokine levels in a murine model of allergic airway inflammation (2013)
  • Author(s): Maki K, Nagai K,Suzuki M, Inomata T, Yoshida T, Nishimura M
  • Organizer: the European Respiratory Society's 23rd Annual Congress
  • Place of Presentation: Fira Barcelona(Spain)
• [Presentation] Clinical Features of Patients with Positive Sputum Culture for Trichosporon Species (2013)
  • Author(s): Takei N Nagai K Inomata T Shibue Y Taniguchi N Shimizu K Suzuki M Konno S Nishimura M
  • Organizer: The 18th Congress of Asian Pacific Society of Respirology
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] プロテアソームの機能異常と病態 (2013)
  • Author(s): 外丸詩野
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌（札幌）
• [Presentation] プロテアソームの発現異常における免疫応答の変化 (2013)
  • Author(s): 紺野沙織、外丸詩野、岸本栞奈、石津明洋、笠原正典
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌（札幌）
• [Presentation] プロテアソームの機能異常と病理作用 (2013)
  • Author(s): 外丸詩野
  • Organizer: 第59回日本病理学会秋期特別総会
  • Place of Presentation: 甲府富士屋ホテル（甲府）
• [Presentation] Aberrant proteasomal expression affects T cell differentiation and functions. (2013)
  • Author(s): Konno S, Tomaru U, Ishizu A, Kasahara M
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] Establishment of invariant NKT cell clone from vasculitis-prone rats,which recognizes autoantigen but not α-galactosylceramide presented by CD1d. (2013)
  • Author(s): Kawakami A, Iinura C, Waki M, Yamaguchi M, Tomaru U, Kasahara M, Yoshiki T, Ishizu A
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] Among subjects’ variation in longitudinal changes in total and three domain scores of St George's Respiratory Questionnaire in chronic obstructive pulmonary disease
  • Author(s): Nagai K,Makita H, Shimizu K, Suzuki M, Konno S, Nishimura M
  • Organizer: 第109回 米国胸部疾患学会総会
  • Place of Presentation: Pennsylvania Convention Center (USA)
• [Presentation] プロテアソームの発現異常による免疫応答の変化
  • Author(s): 紺野沙織、外丸詩野、石津明洋、笠原正典
  • Organizer: 第46回北海道病理談話会（病理分科会）
  • Place of Presentation: 北大医学部学友会館「フラテ」（札幌）
• [Remarks] 北海道大学大学院 医学研究科 呼吸器内科学分野 HP
  • URL: http://fdm.med.hokudai.ac.jp/
• [Remarks] 北海道大学大学院 医学研究科 分子病理学分野 HP
  • URL: http://www.path1-hokudai.jp/path1/