| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Aldehyde dehydrogenases (ALDHs) play a major role in detoxification of aldehydes. High ALDH expression is observed in the stem cells of many organs. A common mutation in ALDH2 gene (ALDH2*2), which affects 40% of East Asians, results in inactivation of the enzyme. This mutation is associated with alcohol flushing syndrome and increased risk for cardiovascular and Alzheimer’s diseases, and some cancers. However, the effect of this ALDH2 mutation on the lung has not been thoroughly examined.
We detected several subtle effects of ALDH2 mutation on lungs. Some of these effects are similar to changes observed during normal aging, suggesting a “premature lung aging” effect.
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