| Project/Area Number |
25461203
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
城戸 貴志 産業医科大学, 医学部, 講師 (30389465)
矢寺 和博 産業医科大学, 医学部, 教授 (40341515)
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| Co-Investigator(Renkei-kenkyūsha) |
Yatera Kazuhiro 産業医科大学, 医学部, 教授 (40341515)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 一酸化窒素 / NO / 一酸化窒素合成酵素 / 線毛 / 原発性線毛運動不全症 / PCD / NO合成酵素 / NOSs完全欠損マウス / NOS / 原発性線毛運動機能不全症 / ノックアウトマウス / 原発性線毛運動異常症 |
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| Outline of Final Research Achievements |
The role of nitric oxide (NO) and NO synthase (NOS) in ciliary motility is unclear. We investigated the role of NO in ciliary motility using triply NOS knockout mice in the present study. Lipopolysaccharide exposure caused more decrease of ciliary beat frequency (CBF) in triply NOS knockout mice compared with wild mice 24 hours exposure, and pre-treatment of isosorbide dinitrate (NO donor) improved the decrease of CBF. These results suggest the important protective role of NO in ciliary motility.
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