Role of Indolethylamine Nmethyltransferase in chronic kidney disease

• Project/Area Number: 25461218
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Uzu Takashi 滋賀医科大学, 医学部, 准教授 (20422884)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 尿細管 / 糖尿病性腎症 / 尿細管細胞 / モノアミン / 慢性腎臓病 / 肥満 / 加齢 / 脂肪酸毒性 / モノアミンメチル化酵素

Outline of Final Research Achievements

We examined the role of Indolethylamine N－methyltransferase, a new target for the tubular damage, in chronic kidney disease. In the proximal culture cells, cell damages were reduced by over-expression of Inmt. On the other hand, those damages were enhanced by the inhibition of Immt by using specific siRNA. However, we found no differences between wild and Inmt KO mice in the chronic kidney diseases models.