Fatty acid composition and diabetic nephropathy

• Project/Area Number: 25461219
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Kanasaki Masami 滋賀医科大学, 医学部, 助教 (30402720)
• Co-Investigator(Renkei-kenkyūsha): UZU Takashi 滋賀医科大学, 医学部, 准教授 (20422884) ; MAEDA Shiro 独立行政法人理化学研究所, 統合生命医科学研究センター, チームリーダー (50314159)
• Research Collaborator: KUME Shinji 滋賀医科大学, 医学部, 特任助教 (00452235)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 糖尿病性腎症 / 脂肪酸 / 飽和脂肪酸 / 不飽和脂肪酸 / 蛋白尿 / 尿細管細胞 / 尿蛋白 / 脂肪酸毒性 / 腎臓 / 内科 / 糖尿病

Outline of Final Research Achievements

This study was designed to identify the role of free fatty acid (FFA) composition in the progression of diabetic nephropathy, a leading cause of renal failure in Japan. Omega-3 unsaturated fatty acid prevented rapid renal function decline without affecting levels of proteinuria in the diabetic patients with overt proteinuria. SCD1 is a rate limiting enzyme converting saturated FFAs to monounsaturated FFAs. SCD1 overexpresion in the cultured proximal tubular cells showed cell-protective role, however SCD1-treansgenic animal show little renopotective effect. We analyzed the relationship between the SNPs in SCD1 gene and the progression of diabetic nephropathy. However, we did not identify any relationship. Although, according to the result from clinical study, unsaturated FFAs may have a renoprotective role in diabetic nephropathy, further examination are needed to conclude the effectiveness of unsaturated FFAs on diabetic nephropathy

Research Products

• [Presentation] 飢餓時の糖新生ならびにケトン産生におけるオートファジーの役割 (2014)
  • Author(s): 高木 彩乃, 久米 真司, 金崎 雅美, 荒木 久澄, 一色 啓二, 荒木 信一, 茶野 徳宏, 柏木 厚典, 宇津 貴, 前川 聡
  • Organizer: 第57回日本糖尿病学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] 糸球体上皮細胞オートファジー不全は糖尿病性腎症における蛋白尿を増悪させる (2014)
  • Author(s): 安田 真子, 田川 安都子, 久米 真司, 田中 敬, 金崎 雅美, 荒木 久澄, 一色 啓二, 荒木 信一, 古家 大祐, 羽田 勝計, 柏木 厚典, 宇津 貴, 前川 聡
  • Organizer: 第57回日本糖尿病学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24