Examination of the mechanism of the renal protection with the statin administration to hypertension-induced ApoE deficient mouse

• Project/Area Number: 25461261
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Osaka Medical College
• Principal Investigator: Hoshiga Masaaki 大阪医科大学, 医学部, 教授 (90309154)
• Co-Investigator(Kenkyū-buntansha): ISHIZAKA Nobukazu 大阪医科大学, 医学部, 教授 (20270879)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 慢性腎臓病 / 高血圧 / 脂質異常症 / アンジオテンシン / 高脂血症 / アポE 欠損マウス / スタチン / メサンギウム増殖 / 生活習慣病 / アポE欠損マウス / 腎障害

Outline of Final Research Achievements

In ApoE deficient mouse with angiotensin II continuous infusion for 4 weeks as dyslipidemia combined hypertension model, glomerular swelling and sclerosis findings, and albuminuria were found. ARB olmesartan inhibited these renal injuries, but vasodilator hydralazine did not.　Statin inhibited the renal injury as well as olmesartan. As the fatty deposition was restrictive, suggesting fatty accumulation is not a main mechanism of the renal injury in these mice. This renal injury is occurred when dyslipidemia and hypertension are combined, suggesting that this renal injury resembles early stage of CKD in human.

Research Products

• [Journal Article] Association between serum immunoglobulin G4 concentration and cardiac function among elderly cardiology inpatients (2014)
  • Author(s): Kazushi Sakane, Kensaku Shibata, Shu-ichi Fujita, Shinsaku Shimamoto, Takahide Ito, Shun Kizawa, Hideaki Morita, Koichi Sohmia, Masaaki Hoshiga, Nobukazu Ishizaka.
  • Journal Title: Geriatr Gerontol Int Volume: 14（3） Issue: 3 Pages: 582-8
  • DOI: 10.1111/ggi.12138
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between circulating fibroblast growth factor 23, α-Klotho, and the left ventricular ejection fraction and left ventricular mass in cardiology inpatients. (2013)
  • Author(s): Shibata K, Fujita S, Morita H, Okamoto Y, Sohmiya K, Hoshiga M, Ishizaka N.
  • Journal Title: PLoS One Volume: 8(9) Issue: 9 Pages: e73184-e73184
  • DOI: 10.1371/journal.pone.0073184
  • Peer Reviewed
• [Journal Article] Serum uric acid is associated with left ventricular hypertrophy independent of serum parathyroid hormone in male cardiac patients. (2013)
  • Author(s): Fujita S, Okamoto Y, Shibata K, Morita H, Ito T, Sohmiya K, Hoshiga M, Ishizaka N
  • Journal Title: PLoS One Volume: 8(12) Issue: 12 Pages: e82735-e82735
  • DOI: 10.1371/journal.pone.0082735
  • Peer Reviewed
• [Presentation] Association between Serum FGF23 Levels and Left Ventricular Hypertrophy in Various CKD Stages. (2014)
  • Author(s): Shun Kizawa, Masaaki Hoshiga, Yuusuke Okamoto, Shuichi Fujita, Kensaku Shibata, Koichi Sohmiya, Nobukazu Ishizaka.
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京 東京国際フォーラム
• [Presentation] Association between circulating fibroblast growth factor 23, α-Klotho, and the left ventricular ejection fraction and left ventricular mass in cardiology inpatients. (2013)
  • Author(s): Shibata K, Fujita S, Morita H, Okamoto Y, Sohmiya K, Hoshiga M, Ishizaka N
  • Organizer: American Heart Association 2013
  • Place of Presentation: アメリカ ダラス