The analysis of hypothalamus and pancreas specific ATF3 double knockout mice

Research Project

Project/Area Number	25461328
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Metabolomics
Research Institution	Gunma University
Principal Investigator	HASHIMOTO HIROMI 群馬大学, 生体調節研究所, 助手 (30323372)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	ATF3 / 視床下部 / 糖尿病 / 膵臓
Outline of Final Research Achievements	The pancreas and hypothalamus are critical for maintaining nutrient and energy homeostasis. Combined disorders in these organs account for the onset of metabolic syndrome. We generated pancreas- and hypothalamus-specific ATF3 knockout mice and showed that these mice displayed better glucose tolerance, neither plasma glucagon nor insulin level was altered in these mice. However, these mice exhibited higher insulin sensitivity, which was accompanied by leaner phenotype due to decreased food intake and increased energy expenditure. We concluded that ATF3 plays an important role in the control of glucose and energy metabolism.

Report

(4 results)