Identification and characterization of a novel protein that regulates adipogenesis and myogenesis

Research Project

Project/Area Number	25461354
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Metabolomics
Research Institution	Okayama University
Principal Investigator	EGUCHI JUN 岡山大学, 大学病院, 助教 (60616366)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	メタボリック症候群 / 肥満症 / 糖尿病 / メタボリックシンドローム / 肥満 / インスリン抵抗性 / 肥満サルコペニア
Outline of Final Research Achievements	Sarcopenic obesity refers to the co-presence of excess fat mass (obesity) and low muscle mass (sarcopenia). Sarcopenic obesity is a major risk factor for metabolic syndrome. Systemic insulin resistance is closely associated with the development of sarcopenic obesity. However, the pathophysiology of sarcopenic obesity in metabolic syndrome remains unclear. We identified Transmembrane protein 97 (Tmem97) as a novel regulator of adipogenesis and myogenesis by using lentiviral short hairpin RNA libraries targeting murine genomes. In the present study, we show that global Tmem97 deficient mice are protected from systemic insulin resistance associated with high fat feeding. These findings suggest that Tmem97 might play a key role in the development of sarcopenic obesity.