Physiological roles of free fatty acids in the regulation of food intake
Project/Area Number |
25461385
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Endocrinology
|
Research Institution | Wakayama Medical University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | グレリン / 消化管ホルモン / 内分泌学 |
Outline of Final Research Achievements |
Medium-chain triglycerides (MCTs) are triglycerides whose fatty acids have an aliphatic tail of 6-12 carbon atoms. Some studies have shown that MCTs can help in the process of excess calorie burning, because MCTs passively diffuse from the GI tract to the portal system and are used quickly. MCTs are also seen as promoting reduced food intake, but the mechanism by which MCTs reduces food intake is still unclear. The aim of the study is to clarify whether medium fatty acids interfere with the biological activities of ghrelin. We used a mini-osmotic continuous infusion pump and kept plasma ghrelin levels 10-fold higher than control mouse. Cumulative food intake of standard-diet-fed mice were significantly increased, but those of MCT-diet-fed mice were not increased. These results suggest that May MCT diet may inhibit orexigenic effect of ghrelin.
|
Report
(4 results)
Research Products
(10 results)
-
[Journal Article] Comprehensive Profiling of GPCR Expression in Ghrelin-producing Cells.2016
Author(s)
Koyama H, Iwakura H, Dote K, Bando M, Hosoda H, Ariyasu H, Kusakabe T, Son C, Hosoda K, Akamizu T, Kangawa K, Nakao K.
-
Journal Title
Endocrinology
Volume: 157
Issue: 2
Pages: 692-704
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
[Journal Article] Clinical effects of ghrelin on gastrointestinal involvement in patients with systemic sclerosis.2014
Author(s)
Ariyasu H, Iwakura H, Yukawa N, Murayama T, Yokode M, Tada H, Yoshimura K, Teramukai S, Ito T, Shimizu A, Yonezawa A, Kangawa K, Mimori T, Akamizu T.
-
Journal Title
Endocrine Journal
Volume: 61
Pages: 735-742
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-