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Physiological roles of free fatty acids in the regulation of food intake

Research Project

Project/Area Number 25461385
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Endocrinology
Research InstitutionWakayama Medical University

Principal Investigator

Ariyasu Hiroyuki  和歌山県立医科大学, 医学部, 講師 (50378650)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsグレリン / 消化管ホルモン / 内分泌学
Outline of Final Research Achievements

Medium-chain triglycerides (MCTs) are triglycerides whose fatty acids have an aliphatic tail of 6-12 carbon atoms. Some studies have shown that MCTs can help in the process of excess calorie burning, because MCTs passively diffuse from the GI tract to the portal system and are used quickly. MCTs are also seen as promoting reduced food intake, but the mechanism by which MCTs reduces food intake is still unclear.
The aim of the study is to clarify whether medium fatty acids interfere with the biological activities of ghrelin. We used a mini-osmotic continuous infusion pump and kept plasma ghrelin levels 10-fold higher than control mouse. Cumulative food intake of standard-diet-fed mice were significantly increased, but those of MCT-diet-fed mice were not increased. These results suggest that May MCT diet may inhibit orexigenic effect of ghrelin.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Open Access: 5 results,  Acknowledgement Compliant: 5 results,  Peer Reviewed: 5 results) Presentation (4 results) (of which Invited: 2 results)

  • [Journal Article] Comprehensive Profiling of GPCR Expression in Ghrelin-producing Cells.2016

    • Author(s)
      Koyama H, Iwakura H, Dote K, Bando M, Hosoda H, Ariyasu H, Kusakabe T, Son C, Hosoda K, Akamizu T, Kangawa K, Nakao K.
    • Journal Title

      Endocrinology

      Volume: 157 Issue: 2 Pages: 692-704

    • DOI

      10.1210/en.2015-1784

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High incorporation of long-chain fatty acids contributes to the efficient production of acylated ghrelin in ghrelin-producing cells.2016

    • Author(s)
      Bando M, Iwakura H, Koyama H, Hosoda H, Shigematsu Y, Ariyasu H, Akamizu T, Kangawa K, Nakao K.
    • Journal Title

      FEBS Lett.

      Volume: 590 Issue: 7 Pages: 992-1001

    • DOI

      10.1002/1873-3468.12132

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Physiological significance of ghrelin revealed by studies using genetically engineered mouse models with modifications in the ghrelin system [Review]2015

    • Author(s)
      Ariyasu H, Akamizu T.
    • Journal Title

      Endocrine Journal

      Volume: 62 Issue: 11 Pages: 953-963

    • DOI

      10.1507/endocrj.EJ15-0361

    • NAID

      130005109821

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2015 Annual Research Report
    • Open Access / Acknowledgement Compliant
  • [Journal Article] Reduction in circulating ghrelin concentration after maturation does not affect food intake.2014

    • Author(s)
      Ariyasu H, Yamada G, Iwakura H, Matsumura S, Inoue K, Kangawa K, Nakao K, Akamizu T.
    • Journal Title

      Endocrine Journal

      Volume: 61 Pages: 1041-1052

    • NAID

      130004704359

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical effects of ghrelin on gastrointestinal involvement in patients with systemic sclerosis.2014

    • Author(s)
      Ariyasu H, Iwakura H, Yukawa N, Murayama T, Yokode M, Tada H, Yoshimura K, Teramukai S, Ito T, Shimizu A, Yonezawa A, Kangawa K, Mimori T, Akamizu T.
    • Journal Title

      Endocrine Journal

      Volume: 61 Pages: 735-742

    • NAID

      130004443975

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signaling pathway2014

    • Author(s)
      Shimada T, Furuta H, Doi A, Ariyasu H, Kawashima H, Wakasaki H, Nishi M, Sasaki H, Akamizu T
    • Journal Title

      Metabolism

      Volume: 63 Issue: 4 Pages: 469-474

    • DOI

      10.1016/j.metabol.2013.12.011

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] グレグレリン過剰分泌Tgマウスの解析を通じた、中鎖脂肪酸の摂食に与える影響の解析2015

    • Author(s)
      有安宏之 他8名
    • Organizer
      第88回 日本内分泌学会学術総会
    • Place of Presentation
      ホテルニューオータニ東京
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] グレリンの生理的及び病態生理学的意義の検討とそれに基づいたトランスレーショナルリサーチ2015

    • Author(s)
      有安宏之
    • Organizer
      第88回 日本内分泌学会学術総会
    • Place of Presentation
      ホテルニューオータニ東京
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] グレリン過剰分泌Tgマウスの解析を通じた、中鎖脂肪酸の摂食に与える影響の解析2014

    • Author(s)
      有安宏之、竹島健、浦木進丞、川嶋弘道、古田浩人、西理宏、中尾一和、寒川賢治、赤水尚史
    • Organizer
      第88回日本内分泌学会
    • Place of Presentation
      ホテルニューオータニ東京
    • Year and Date
      2014-04-23 – 2014-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] グレリンの生理的及び病態生理学的意義の検討とそれに基づいたトランスレーショナルリサーチ2014

    • Author(s)
      有安宏之
    • Organizer
      第88回日本内分泌学会
    • Place of Presentation
      ホテルニューオータニ東京
    • Year and Date
      2014-04-23 – 2014-04-25
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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