| Project/Area Number |
25461387
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Tottori University |
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Principal Investigator |
YOSHIDA Akio 鳥取大学, 医学(系)研究科(研究院), 特任教授 (90158428)
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| Co-Investigator(Kenkyū-buntansha) |
HISATOME Ichiro 鳥取大学, 医学系研究科, 教授 (60211504)
鈴木 幸一 帝京大学, 医療技術学部, 教授 (20206478)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Koichi 帝京大学, 医療技術部, 教授 (20206478)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 甲状腺 / ヨード / ペンドリン / イオン輸送体 / 陰イオン交換体 / 橋本病 / バセドウ病 / ELISA / ヨード輸送体 / pendrin / Immunopercipitation / Graves disease / Hashimoto thyroiditis / painless thyroiditis / subacue thyroiditis / anti-pendrin antibody / Graves' disease / subacute thyroiditis |
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| Outline of Final Research Achievements |
Autoimmune thyroid diseases are diagnosed by existence of autoーantibody against thyroglobulin and/or thyro-peroxidase in the patients’ sera. Pendrin is thyroid specific protein existｓ in the apical membrane of thyroid cells that transportｓ iodide. We have revealed that all of the patients with Hashimoto disease have anti-pendrin antibody in the sera using western blot analysis. We tried to establish ELISA for this antibody for the advance of diagnosis of autoimmune thyroid disease. We have obtained several results that will contribute the establishment of ELISA in the near future.
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