Investigation of a contribution of genes coding for paired receptors, LILR and LAIR families, to connective tissue diseases
Project/Area Number |
25461467
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Collagenous pathology/Allergology
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Research Institution | University of Tsukuba |
Principal Investigator |
KAWASAKI Aya 筑波大学, 医学医療系, 助教 (30532816)
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Co-Investigator(Renkei-kenkyūsha) |
TSUCHIYA Naoyuki 筑波大学, 医学医療系, 教授 (60231437)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 全身性エリテマトーデス / 全身性強皮症 / 疾患感受性遺伝子 / LILR / HLA-G / 多型 / ANCA関連血管炎 / SNP / LAIR |
Outline of Final Research Achievements |
To examine whether genes coding for paired receptors, leukocyte immunoglobulin (Ig)-like receptors (LILR), and one of their ligands, HLA-G, contribute to susceptibility to connective tissue diseases such as systemic lupus erythematosus (SLE), association study of LILR and HLA-G genes was conducted in a Japanese population. LILRA3 deletion allele was significantly increased in patients with systemic sclerosis with anti‐topoisomerase I antibodies. With respect to HLA-G, 14bp insertion allele in 3’ untranslated region was associated with SLE with the age of onset <20 years independently of the SLE susceptible and protective HLA-DRB1 alleles.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Association of IRF5 polymorphism with MPO-ANCA positive vasculitis in a Japanese population2013
Author(s)
Kawasaki A, Inoue N, Ajimi C, Sada K, Kobayashi S, Yamada H, Furukawa H, Sumida T, Tohma S, Miyasaka N, Matsuo S, Ozaki S, Hashimoto H, Makino H, Harigai M, Tsuchiya N
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Journal Title
Genes Immun
Volume: 14
Issue: 8
Pages: 527-529
DOI
Related Report
Peer Reviewed
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[Presentation] Association of HLA-G and Leukocyte Immunoglobulin-like Receptor A3 Polymorphisms with the Susceptibility to Pulmonary Hyterpention in Systemic Sclerosis2015
Author(s)
Yuki Hachiya, Aya Kawasaki, Takashi Matsushita, Hiroshi Furukawa, Shouhei Nagaoka, Kota Shimada, Shoji Sugii, Keigo Setoguchi, Akira Okamoto, Noriyuki Chiba, Eiichi Suematsu, Masao Katayama, Shunsei Hirohata, Hajime Kono, Kiyoshi Migita, Takayuki Sumida, Shigeto Tohma, Minoru Hasegawa, Naoyuki Tsuchiya et al
Organizer
The 2015 American College of Rheumatology Annual Scientific Meeting
Place of Presentation
Moscone Center (San Francisco, USA)
Year and Date
2015-11-08
Related Report
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[Presentation] Association study of LILRA4 with systemic lupus erythematosus2015
Author(s)
Aya Kawasaki, Hiroshi Furukawa, Yuya Kondo, Shouhei Nagaoka, Kota Shimada, Yoshinari Takasaki, Hiroshi Hashimoto, Takayuki Sumida, Shigeto Tohma, Naoyuki Tsuchiya
Organizer
11th International Congress on Systemic Lupus Erythematosus
Place of Presentation
HOFBURG Vienna Congress Center(Vienna, Austria)
Year and Date
2015-09-04
Related Report
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[Presentation] Association of Leukocyte Immunoglobulin-like Receptor A3 (LILRA3) Deletion Polymorphism with Systemic Sclerosis2014
Author(s)
Yuki Hachiya, Aya Kawasaki, Takashi Matsushita, Hiroshi Furukawa, Shouhei Nagaoka, Kota Shimada, Shoji Sugii, Takayuki Sumida, Shigeto Tohma, Minoru Hasegawa, Manabu Fujimoto, Shinichi Sato, Kazuhiko Takehara, Naoyuki Tsuchiya
Organizer
The 2014 American College of Rheumatology Annual Scientific Meeting
Place of Presentation
Boston Convention and Exhibit Center(Boston, USA)
Year and Date
2014-11-16
Related Report
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[Presentation] Association of functional polymorphisms in IRF2 with systemic lupus erythematosus in a Japanese population.
Author(s)
Aya Kawasaki, Hiroshi Furukawa, Nao Nishida, Eiji Warabi, Yuya Kondo, Satoshi Ito, Isao Matsumoto, Makio Kusaoi, Akiko Suda, Shouhei Nagaoka, Keigo Setoguchi,Tatsuo Nagai, Shunsei Hirohata, Katsushi Tokunaga, Yoshinari Takasaki, Hiroshi Hashimoto, Takayuki Sumida, Shigeto Tohma, Naoyuki Tsuchiya
Organizer
ACR/ARHP 2013 Annual Meeting
Place of Presentation
San Diego Convention Center (San Diego, USA)
Related Report
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