Potential of SPACIA1 as a druggable target of rheumatoid arthritis
| Project/Area Number |
25461490
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
Fujii Ryoji 聖マリアンナ医科大学, 医学研究科, 講師 (10333535)
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| Co-Investigator(Renkei-kenkyūsha) |
YUDO Kazuo 聖マリアンナ医科大学, 医学研究科, 教授 (60272928)
KOMATSU Rie 聖マリアンナ医科大学, 医学研究科, 研究技術員 (80517475)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 関節リウマチ / 滑膜 / 細胞増殖 / 炎症 / 滑膜炎 / リウマチ |
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| Outline of Final Research Achievements |
SPACIA1 is a gene associated with abnormal synovial proliferation in rheumatoid arthritis (RA). We previously showed that SPACIA1 transgenic mice exhibited early onset and rapid progression of collagen-induced arthritis (CIA). In the present study, we showed SPACIA1 could be involved in expression of CDK6 gene, a G1 phase-cell cycle factor, via mRNA stability. We also confirmed that TNF-alpha regulates CDK6 expression on transcriptional level in RA-synoviocytes. Unfortunately, even SPACIA1-deficient mice were investigated onset of CIA, therefore we focused CDK6, not SPACIA1, to assess the potential as a druggable target of RA. CDK6 knockdown by its siRNA inhibited the proliferation of RA-synoviocytes. Moreover, treatment of CDK6 inhibitor to mice almost completely prevented development of CIA.
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Report
(5 results)
Research Products
(9 results)
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[Presentation] SPACIA1/SAAL1-Deficient Mice Show Reduced Disease Progression in Collagen-Induced Arthritis.2015
Author(s)
Ryoji Fujii, Iwao Seki, Rie Komatsu, Miwa Takai, Tomomi Kohara, Tomoo Sato, Kohji Konomi, Hiroyuki Aono, Kazuo Yudoh, Kusuki Nishioka, Toshihiro Nakajima
Organizer
American College of Rheumatology
Place of Presentation
San Francisco, USA
Year and Date
2015-11-10
Related Report
Int'l Joint Research
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