| Project/Area Number |
25461502
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Yamaguchi University (2015)
Wakayama Medical University (2013-2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANAI Kuninobu 和歌山県立医科大学, 医学部, 学内助教 (90649055)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | TNF-LIGHT / 窒素化ストレス / 呼気NO / 難治性喘息 / 気道リモデリング / クロストーク / TNF-LIGTH / 呼気ＮＯ |
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| Outline of Final Research Achievements |
The molecular mechanism of airway remodeling in patients with asthma is not fully understood. TNF family member LIGHT (LIGHT) expressed on inflammatory cells may trigger airway remodeling via TGF-beta or IL13 overexpression. Moreover, patients with severe asthma are reported to have more nitrosative stress than patients with non-severe asthma.Therefore,the aim of this study is to elucidate whether there is cross-talk between LIGHT and nitrosative stress in the fixed airway obstruction of asthma.
Asthmatic patients with airway obstruction despite usual treatment and asthmatic patients with favorable pulmonary function were enrolled.Induced sputum was collected and LIGHT and 3-nitrotyrosine (3-NT), which is a footprint of nitrosative stress, were quantified by immunohistochemical staining.
As a result,it was suggested that cross-talk between LIGHT and nitrosative stress might be related to the pathophysiology of airway remodeling in asthma.
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