Human papillomavirus genotypes and HPV16 E6/E7 variants among patients with genital cancers in Asia

• Project/Area Number: 25461509
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Kanazawa University
• Principal Investigator: ICHIMURA HIROSHI 金沢大学, 医学系, 教授 (10264756)
• Co-Investigator(Kenkyū-buntansha): SASAGAWA Toshiyuki 金沢医科大学, 医学系, 教授 (30272975)
• Co-Investigator(Renkei-kenkyūsha): ISHIZAKI Azumi 金沢大学, 医学系, 助教 (30456420) ; BI Xiuqiong 金沢大学, 医学系, 助教 (50565413)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ヒトパピローマウイルス / がん化 / HPV遺伝子型 / HPV E6・E7亜型 / ベトナム / 子宮頚癌 / 生殖器癌 / 分子疫学 / HPV関連がん / 子宮頸癌 / HPV E6/E7亜型

Outline of Final Research Achievements

This study aimed to investigate human papilloma virus (HPV) genotype distribution and the HPV16 E6/E7 variations in Vietnamese patients with genital cancers, such as cervical, vulvar/vaginal, and penile cancers. The most prevalent HPV genotype in the women with normal cervical cytology (HPV52) was different from those in patients with genital cancers (HPV16/18). More than 85% of genital cancers could be prevented with the current vaccine targeting HPV 16/18 in Vietnam. HPV16 E6/E7 European Asian lineage may be less oncogenic. The G to A and C to T mutations at specific nucleotide positions of HPV16 E6/E7 genes may be involved in the development of cancers.

Research Products

• [Int'l Joint Research] ハイフォン医科薬科大学/ハノイ国立がん病院/ハノイ国立皮膚性感染症病院(ベトナム)
• [Int'l Joint Research] サンラサロ病院(フィリピン)
• [Journal Article] Human papillomavirus infection in male patients with STI-related symptoms in Hanoi, Vietnam. (2016)
  • Author(s): Le HHL, Bi X, Ishizaki A, Le HV, Nguyen TV, Hosaka N, Ichimura H.
  • Journal Title: Journal of Medical Virology Volume: 88 Issue: 6 Pages: 1059-1066
  • DOI: 10.1002/jmv.24422
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Two-year outcome of first-line antiretroviral therapy among HIV-1 vertically infected children in Hanoi (2014)
  • Author(s): Pham HV, Ishizaki A, Nguyen LV, Phan CTT, Phung TTB, Takemoto K, Pham AN, Bi X, Khu DTK, and Ichimura H.
  • Journal Title: Int J STD AIDS Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Diversity of HIV-1 and Drug Resistance Mutations among Injecting Drug Users in Kenya (2013)
  • Author(s): Osman S, Lihana RW, Kibaya RM, Ishizaki A, Bi X, Okoth FA, Ichimura H, Lwembe RM
  • Journal Title: AIDS Res Hum Retroviruses Volume: 29 Issue: 1 Pages: 187-190
  • DOI: 10.1089/aid.2012.0182
  • Peer Reviewed
• [Journal Article] Infection with High-risk HPV Types among Female Sex Workers in Northern Vietnam (2013)
  • Author(s): Hoang HT, Ishizaki A, Nguyen CH, Tran VT, Matsushita K, Saikawa K, Hosaka N, Pham HV, Bi X, Ta VT, Pham TV, and Ichimura H.
  • Journal Title: J Med Virol Volume: 85 Issue: 2 Pages: 288-294
  • DOI: 10.1002/jmv.23456
  • NAID: 120005253233
  • Peer Reviewed
• [Journal Article] E6 and E7 variants of human papillomavirus-16 and -52 in Japan, the Philippines, and Vietnam. (2013)
  • Author(s): Ishizaki A, Matsushita K, Hoang HT, Agdamag DM, Nguyen CH, Tran VT, Sasagawa T, Saikawa K, Lihana R, Pham HV, Bi X, Ta VT, Pham TV, and Ichimura H.
  • Journal Title: J Med Virol Volume: 85 Issue: 6 Pages: 1069-1076
  • DOI: 10.1002/jmv.23566
  • NAID: 120005254073
  • Peer Reviewed
• [Presentation] ベトナムの男性性感染症患者におけるヒトパピローマウイルス感染 (2015)
  • Author(s): Le Ha Long Hai、畢 袖晴、石崎 有澄美、市村 宏
  • Organizer: 第30回日本国際保健医療学会学術大会
  • Place of Presentation: 金沢大学自然科学本館
  • Year and Date: 2015-11-21
• [Presentation] HPV infection in Asia (2015)
  • Author(s): 市村 宏
  • Organizer: Vietnamese-Japanese Students' Scientific Exchange Meeting 2015
  • Place of Presentation: 京都大学（京都市）
  • Year and Date: 2015-10-31
  • Int'l Joint Research / Invited
• [Presentation] Human Papilloma Virus infection and HPV16 E6/E7 variants among cervical cancer patients in Vietnam (2014)
  • Author(s): Mai Thi Phuong Nguyen, Toshiyuki Sasagawa, Hiroshi Ichimura, et al.
  • Organizer: 第62回に本ウイルス学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-11-10
• [Presentation] アジア（ベトナム、日本）の子宮頸癌患者におけるHPV感染―遺伝子型・E6/E7亜型の分布― (2014)
  • Author(s): 市村 宏、Mai Thi Phuong Nguyen, 笹川寿之、ほか
  • Organizer: 北陸腸内細菌研究会2014
  • Place of Presentation: 金沢市
  • Year and Date: 2014-07-19
• [Presentation] ベトナムのB型慢性肝炎患者における薬剤耐性ウイルス出現に関する検討 (2013)
  • Author(s): 石崎有澄美、Phan HV、畢 袖晴、市村 宏
  • Organizer: 第56回日本感染症学会中日本地方会学術集会、第83回日本感染症学会西日本地方会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Sequence variation in the HIV-1 Gag gene among rapid, slow and non progressor children (2013)
  • Author(s): Matilda Saina, Xiuqiong Bi, Raphael Lihana, Hiroshi Ichimura
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Change in the prevalence of HIV-1 and the rate of circulating drug-resistant HIV-1 in Hai Phong, Northern Viet Nam. (2013)
  • Author(s): Pham VH, Nguyen HC, Hoang TTH, Ishizaki A, Phan TTC, Bi X, Pham VT, Ichimura H
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Mother-to-Child transmission of HIV-1 in Northern Vietnam (2013)
  • Author(s): Phan TTC, Pham HV, Ishizaki A, Bi X, Ichimura H
  • Organizer: 第27回日本エイズ学会学術集会総会
  • Place of Presentation: 熊本市民会館
• [Presentation] ヒト免疫不全ウイルス（HIV-1)感染者に対するプロバイオティクスの投与効果の解明
  • Author(s): 市村 宏、石崎有澄美、畢 袖晴、Khu Thi Khanh Dung、ヤクルト中央研究所
  • Organizer: 平成25年度北陸腸内細菌研究会
  • Place of Presentation: 福井県国際交流会館
• [Presentation] アジアのHPV感染症
  • Author(s): 市村 宏
  • Organizer: 日本臨床細胞学会第39回和歌山県支部学術集会
  • Place of Presentation: 和歌山農協会館
  • Invited
• [Remarks] 金沢大学医薬保健研究域医学系循環医科学専攻ウイルス感染症制御学
  • URL: http://virus.w3.kanazawa-u.ac.jp