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Human papillomavirus genotypes and HPV16 E6/E7 variants among patients with genital cancers in Asia

Research Project

Project/Area Number 25461509
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Infectious disease medicine
Research InstitutionKanazawa University

Principal Investigator

ICHIMURA HIROSHI  金沢大学, 医学系, 教授 (10264756)

Co-Investigator(Kenkyū-buntansha) SASAGAWA Toshiyuki  金沢医科大学, 医学系, 教授 (30272975)
Co-Investigator(Renkei-kenkyūsha) ISHIZAKI Azumi  金沢大学, 医学系, 助教 (30456420)
BI Xiuqiong  金沢大学, 医学系, 助教 (50565413)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsヒトパピローマウイルス / がん化 / HPV遺伝子型 / HPV E6・E7亜型 / ベトナム / 子宮頚癌 / 生殖器癌 / 分子疫学 / HPV関連がん / 子宮頸癌 / HPV E6/E7亜型
Outline of Final Research Achievements

This study aimed to investigate human papilloma virus (HPV) genotype distribution and the HPV16 E6/E7 variations in Vietnamese patients with genital cancers, such as cervical, vulvar/vaginal, and penile cancers. The most prevalent HPV genotype in the women with normal cervical cytology (HPV52) was different from those in patients with genital cancers (HPV16/18). More than 85% of genital cancers could be prevented with the current vaccine targeting HPV 16/18 in Vietnam. HPV16 E6/E7 European Asian lineage may be less oncogenic. The G to A and C to T mutations at specific nucleotide positions of HPV16 E6/E7 genes may be involved in the development of cancers.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (1 results)

  • [Int'l Joint Research] ハイフォン医科薬科大学/ハノイ国立がん病院/ハノイ国立皮膚性感染症病院(ベトナム)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] サンラサロ病院(フィリピン)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Human papillomavirus infection in male patients with STI-related symptoms in Hanoi, Vietnam.2016

    • Author(s)
      Le HHL, Bi X, Ishizaki A, Le HV, Nguyen TV, Hosaka N, Ichimura H.
    • Journal Title

      Journal of Medical Virology

      Volume: 88 Issue: 6 Pages: 1059-1066

    • DOI

      10.1002/jmv.24422

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Two-year outcome of first-line antiretroviral therapy among HIV-1 vertically infected children in Hanoi2014

    • Author(s)
      Pham HV, Ishizaki A, Nguyen LV, Phan CTT, Phung TTB, Takemoto K, Pham AN, Bi X, Khu DTK, and Ichimura H.
    • Journal Title

      Int J STD AIDS

      Volume: 印刷中

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diversity of HIV-1 and Drug Resistance Mutations among Injecting Drug Users in Kenya2013

    • Author(s)
      Osman S, Lihana RW, Kibaya RM, Ishizaki A, Bi X, Okoth FA, Ichimura H, Lwembe RM
    • Journal Title

      AIDS Res Hum Retroviruses

      Volume: 29 Issue: 1 Pages: 187-190

    • DOI

      10.1089/aid.2012.0182

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Infection with High-risk HPV Types among Female Sex Workers in Northern Vietnam2013

    • Author(s)
      Hoang HT, Ishizaki A, Nguyen CH, Tran VT, Matsushita K, Saikawa K, Hosaka N, Pham HV, Bi X, Ta VT, Pham TV, and Ichimura H.
    • Journal Title

      J Med Virol

      Volume: 85 Issue: 2 Pages: 288-294

    • DOI

      10.1002/jmv.23456

    • NAID

      120005253233

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] E6 and E7 variants of human papillomavirus-16 and -52 in Japan, the Philippines, and Vietnam.2013

    • Author(s)
      Ishizaki A, Matsushita K, Hoang HT, Agdamag DM, Nguyen CH, Tran VT, Sasagawa T, Saikawa K, Lihana R, Pham HV, Bi X, Ta VT, Pham TV, and Ichimura H.
    • Journal Title

      J Med Virol

      Volume: 85 Issue: 6 Pages: 1069-1076

    • DOI

      10.1002/jmv.23566

    • NAID

      120005254073

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ベトナムの男性性感染症患者におけるヒトパピローマウイルス感染2015

    • Author(s)
      Le Ha Long Hai、畢 袖晴、石崎 有澄美、市村 宏
    • Organizer
      第30回日本国際保健医療学会学術大会
    • Place of Presentation
      金沢大学自然科学本館
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] HPV infection in Asia2015

    • Author(s)
      市村 宏
    • Organizer
      Vietnamese-Japanese Students' Scientific Exchange Meeting 2015
    • Place of Presentation
      京都大学(京都市)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Human Papilloma Virus infection and HPV16 E6/E7 variants among cervical cancer patients in Vietnam2014

    • Author(s)
      Mai Thi Phuong Nguyen, Toshiyuki Sasagawa, Hiroshi Ichimura, et al.
    • Organizer
      第62回に本ウイルス学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-10
    • Related Report
      2014 Research-status Report
  • [Presentation] アジア(ベトナム、日本)の子宮頸癌患者におけるHPV感染―遺伝子型・E6/E7亜型の分布―2014

    • Author(s)
      市村 宏、Mai Thi Phuong Nguyen, 笹川寿之、ほか
    • Organizer
      北陸腸内細菌研究会2014
    • Place of Presentation
      金沢市
    • Year and Date
      2014-07-19
    • Related Report
      2014 Research-status Report
  • [Presentation] ベトナムのB型慢性肝炎患者における薬剤耐性ウイルス出現に関する検討2013

    • Author(s)
      石崎有澄美、Phan HV、畢 袖晴、市村 宏
    • Organizer
      第56回日本感染症学会中日本地方会学術集会、第83回日本感染症学会西日本地方会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] Sequence variation in the HIV-1 Gag gene among rapid, slow and non progressor children2013

    • Author(s)
      Matilda Saina, Xiuqiong Bi, Raphael Lihana, Hiroshi Ichimura
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] Change in the prevalence of HIV-1 and the rate of circulating drug-resistant HIV-1 in Hai Phong, Northern Viet Nam.2013

    • Author(s)
      Pham VH, Nguyen HC, Hoang TTH, Ishizaki A, Phan TTC, Bi X, Pham VT, Ichimura H
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] Mother-to-Child transmission of HIV-1 in Northern Vietnam2013

    • Author(s)
      Phan TTC, Pham HV, Ishizaki A, Bi X, Ichimura H
    • Organizer
      第27回日本エイズ学会学術集会総会
    • Place of Presentation
      熊本市民会館
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒト免疫不全ウイルス(HIV-1)感染者に対するプロバイオティクスの投与効果の解明

    • Author(s)
      市村 宏、石崎有澄美、畢 袖晴、Khu Thi Khanh Dung、ヤクルト中央研究所
    • Organizer
      平成25年度北陸腸内細菌研究会
    • Place of Presentation
      福井県国際交流会館
    • Related Report
      2013 Research-status Report
  • [Presentation] アジアのHPV感染症

    • Author(s)
      市村 宏
    • Organizer
      日本臨床細胞学会第39回和歌山県支部学術集会
    • Place of Presentation
      和歌山農協会館
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] 金沢大学医薬保健研究域医学系循環医科学専攻ウイルス感染症制御学

    • URL

      http://virus.w3.kanazawa-u.ac.jp

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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