Study of the effect of bisphosphonate on osteocyte function and bone formation
| Project/Area Number |
25461548
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka University |
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Principal Investigator |
Kitaoka Taichi 大阪大学, 医学(系)研究科(研究院), 助教 (20599229)
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| Co-Investigator(Kenkyū-buntansha) |
NAMBA Noriyuki 大阪大学, 大学院医学系研究科, 招聘教員 (10379076)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | スクレロスチン / 骨形成不全症 / ビスホスホネート / 骨代謝マーカー / ビスフォスフォネート / 骨細胞 |
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| Outline of Final Research Achievements |
We examined the levels of sclerostin, an inhibitor of bone formation, during bisphosphonate treatment in patients with osteogenesis imperfecta, and evaluated the influence of bisphosphonate on bone formation. Serum sclerostin concentration did not change significantly during the bisphosphonate treatment. On the other hand, bone-specific alkaline phosphatase (BAP), a bone formation marker, was associated significantly with the change of sclerostin levels. Since the levels of BAP gradually increased during childhood, it was suggested that the change of sclerostin levels may, in part, contribute to the effect of bone formation with bisphosphonate treatment and the growth.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Serum Fibroblast Growth Factor 23 Is a Useful Marker to Distinguish Vitamin D-Deficient Rickets from Hypophosphatemic Rickets.2014
Author(s)
Kubota T, Kitaoka T, Miura K, Fujiwara M, Ohata Y, Miyoshi Y, Yamamoto K, Takeyari S, Yamamoto T, Namba N, Ozono K.
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Journal Title
Hormone Research in Paediatrics
Volume: [Epub ahead of print]
Issue: 4
Pages: 1-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Two Japanese familial cases of Caffey disease with and without the common COL1A1 mutation and normal bone density, and review of the literature.2014
Author(s)
Taichi Kitaoka, Yoko Miyoshi, Noriyuki Namba, Kohji Miura, Takuo Kubota, Yasuhisa Ohata, Makoto Fujiwara, Masaki Takagi, Tomonobu Hasegawa, Harald Jüppner, Keiichi Ozono
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Journal Title
European Journal of Pediatrics
Volume: [Epub ahead of print]
Issue: 6
Pages: 1-6
DOI
Related Report
Peer Reviewed
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[Presentation] Correlation between genotype and phenotype in patients with osteogenesis imperfect using targeted exome sequencing.2015
Author(s)
Varoona Bizaoui-Auffret, Takuo Kubota, Yasuhisa Ohata, Nobutoshi Nawa, Hirofumi Nakayama, Keiko Yamamoto, Makoto Fujiwara, Taichi Kitaoka, Satoshi Takakuwa, Noriyuki Namba, Keiichi Ozono
Organizer
第48回 発育異常研究会
Place of Presentation
大阪
Year and Date
2015-06-20
Related Report
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