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Analysis of a mouse model showing autism-related behavioral abnormalities

Research Project

Project/Area Number 25461567
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionMatsuyama University

Principal Investigator

Nakajima Mitsunari  松山大学, 薬学部, 准教授 (70311404)

Co-Investigator(Kenkyū-buntansha) FURUKAWA YOSHIKO  松山大学, 薬学部, 教授 (20219108)
OKUYAMA SATOSHI  松山大学, 薬学部, 助教 (40550380)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords自閉症 / モデルマウス / 性差 / 社会性行動
Outline of Final Research Achievements

Wnt1-cre and Wnt1-GAL4 double transgenic (dTg) mice are used to study neural crest cell lineages, and are achieved utilizing either the Cre/loxP or GAL4/UAS system. In the present study, we demonstrated behavioral abnormalities in dTg mice that are associated with psychiatric disorders, such as increased locomotor activity, decreased social behavior, and an increased frequency in vertical jumping. Of these, the proclivity for vertical jumping was observed only in male dTg mice. In contrast, MK-801 administration induced hyperlocomotion in only the female dTg mice, which was subsequently rescued by treatment with clozapine. Furthermore, the concentrations of prolactin in the sera, and oxytocin in the hypothalamus, were both reduced only in female dTg mice, compared to controls. These results suggest that the phenotype of psychiatric disorders may be influenced by gender-gene interactions.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] 精神疾患様異常行動、聴覚過敏、そして脳内オキシトシン含量の低下を示すマウスの紹介2015

    • Author(s)
      中島光業、奥山聡、古川美子
    • Journal Title

      愛媛県病薬会誌

      Volume: 117 Pages: 17-19

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Dilation of the inferior colliculus and hypersensitivity to sound in Wnt1-cre and Wnt1-GAL4 double-transgenic mice.2014

    • Author(s)
      Nakajima M, Nishikawa C, Miyasaka Y, Kikkawa Y, Mori H, Tsuruta M, Okuyama S, Furukawa Y.
    • Journal Title

      Neurosci Lett.

      Volume: 566 Pages: 236-240

    • DOI

      10.1016/j.neulet.2014.02.061

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 精神疾患様異常行動と聴覚過敏を伴うWnt1-cre, Wnt1-GAL4ダブルトランスジェニックマウスにおける脳内オキシトシン含量の低下2015

    • Author(s)
      中島光業、渡部貴司、青木ルイ、清水理誠、奥山聡、古川美子
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Wnt1-cre, Wnt1-GAL4ダブルトランスジェニックマウスで認められる精神疾患様行動異常と聴覚過敏2014

    • Author(s)
      中島光業、西川知沙、宮坂勇輝、吉川欣亮、森久倫、鶴田桃子、奥山聡、古川美子
    • Organizer
      日本神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 精神疾患モデルマウスで認められる下丘肥大と聴覚過敏2014

    • Author(s)
      中島光業、西川知沙、宮坂勇輝、吉川欣亮、森久倫、鶴田桃子、奥山聡、古川美子
    • Organizer
      日本薬学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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