Study of new IL-18 inhibitors and molecular targeting molecules for beta-trefoil cytokines
Project/Area Number |
25461588
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Gifu University |
Principal Investigator |
Kato Zenichiro 岐阜大学, 医学(系)研究科(研究院), 教授 (90303502)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | IL-18 / 立体構造 / 複合体 / 創薬 |
Outline of Final Research Achievements |
The binding mode of IL-18 was determined at atomic resolution to investigate the complex structure of Il-18 ligand, Il-18 receptor alpha, and IL-18 receptor beta. The candidate drugs were obtained through the structural information. The candidates have different mode of inhibition from those we obtained before this study. The new molecular mechanism of the future drugs will open up a new avenue for drug development, especially for the beta-trefoil cytokines including IL-1,IL-18 and IL33.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] The structural basis for receptor recognition of human interleukin-182014
Author(s)
Naotaka Tsutsumi, Takeshi Kimura, Kyohei Arita, Mariko Ariyoshi, Hidenori Ohnishi, Takahiro Yamamoto, Xiaobing Zuo, Katsumi Maenaka, Enoch Y. Park, Naomi Kondo, Masahiro Shirakawa, Hidehito Tochio and Zenichiro Kato
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Journal Title
Nat. Commun.
Volume: 5 5340
Issue: 1
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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