| Project/Area Number |
25461603
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TSUCHIYA kunihiko 京都府立医科大学, 医学(系)研究科(研究院), 講師 (90381938)
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| Co-Investigator(Kenkyū-buntansha) |
HOSOI hajime 京都府立医科大学, 大学院医学研究科小児発達医学, 教授 (20238744)
IEHARA tomoko 京都府立医科大学, 大学院医学研究科小児発達医学, 准教授 (20285266)
MIYACHI mitsuru 京都府立医科大学, 大学院医学研究科小児発達医学, 助教 (40584983)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 横紋筋肉腫 / microRNA / liquid biopsy / バイオマーカー / 腫瘍マーカー / miR-206 / 転移 |
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| Outline of Final Research Achievements |
miR-206 is a muscle-specific microRNA and is much more strongly expressed in sera of patients with rhabdomyosarcoma (RMS) than in sera of patients with non-RMS tumors. Here, we analyzed the prognostic significance of circulating miR-206 values in serum specimens of RMS patients. Serum miR-206 expression levels were higher in RMS patients than in non-RMS patients with an area under the ROC curve of 0.8705, sensitivity of 0.714 and specificity of 0.938. The cut-off value was 164.1 copies/μl serum. Progression free survival (PFS) was negatively influenced by a high serum miR-206 expression level (2.5-year PFS; 10.7 % vs 77.9 %). miR-206 can be a novel biomarker for treatment stratification of RMS. The limitations of our study include a retrospective design, small sample size and non-uniform treatment. The Japan Rhabdomyosarcoma Study Group will prospectively validate its prognostic significance in a large cohort of uniformly-treated patients.
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