Mesangial viral and psuedoviral immunity: possible involvement in the pathogenesis of glomerulonephritis
Project/Area Number |
25461615
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Hirosaki University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
IMAIZUMI TADAATSU 弘前大学, 大学院医学研究科, 教授 (90232602)
YOSHIDA HIDEMI 弘前大学, 大学院医学研究科, 講師 (40201008)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 腎炎症候群 / 自然免疫 / メサンギウム細胞 / 炎症性ケモカイン / Toll-like receptor 3 / ISG15 / Interferon-β / CXCL1 / TLR3 / human mesangial cells / pseudoviral immunity / lupus nephritis / toll-like receptor 3 / Mx1 / MCP-1 / CCL5 / mizoribine |
Outline of Final Research Achievements |
Since viral infections activate type I interferon (IFN) pathways and cause subsequent release of IFN-dependent proinflammatory chemokines/cytokines, the innate immune system plays an important role in the pathogenesis of glomerulonephritis (GN). So far, we have examined the toll-like receptor (TLR) 3 signaling cascades treated with polyinosinic-polycytidylic acid (poly IC), a synthetic analogue of viral dsRNA, that makes “pseudoviral” infection in cultured human mesangial cells (MCs). We found that the activation of mesangial TLR3 upregulated the expression of functional molecules acting as monocyte/macrophage and lymphocyte chemoattractants in MCs. Further, intense glomerular expressions of these functional molecules were observed in biopsy specimens from children with GN. These observations further support the implication of “pseudoviral” immunity in the pathogenesis of GN.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Interferon-Dependent Transcript, Is Involved in a Negative Feedback Loop in Innate Immune Reactions in Human Mesangial Cells.2016
Author(s)
Imaizumi T, Shimada T, Matsumiya T, Yoshida H, Watanabe S, Tsuruga K, Kawaguchi S, Murakami M, Joh K, Tanaka H.
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Journal Title
Nephron
Volume: 132
Issue: 2
Pages: 144-152
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Toll-like receptor 3 signaling contributes to the expression of a neutrophil chemoattractant, CXCL1 in human mesangial cells.2015
Author(s)
Imaizumi T, Aizawa T, Segawa C, Shimada M, Tsuruga K, Kawaguchi S, Matsumiya T, Yoshida H, Joh K, Tanaka H:
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Journal Title
Clinical and Experimental Nephrology
Volume: 19
Issue: 5
Pages: 761-770
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Tumor necrosis factor-α synergistically enhances polyinosinic-polycytidylic acid-induced toll-like receptor 3 signaling in cultured normal human mesangial cells: possible involvement in the pathogenesis of lupus nephritis2014
Author(s)
Imaizumi T, Aizawa T, Hayakari R, Xing F, Meng P, Tsuruga K, Matsumiya T, Yoshida H, Wang L, Tatsuta T, Tanaka H
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Journal Title
Clin Exp Nephrol
Volume: (online ahead of print)
Issue: 1
Pages: 75-81
DOI
Related Report
Peer Reviewed / Open Access
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