| Project/Area Number |
25461652
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tokoha University (2014-2016)
Jichi Medical University (2013) |
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Principal Investigator |
SUGIE Hideo 常葉大学, 保健医療学部, 教授 (60119980)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUDA Tokiko 浜松医科大学, 小児科, 准教授 (10458268)
KONO Yumi 自治医科大学, 小児科, 教授 (50243390)
HIRASAWA Kyoko 東京女子医科大学, 小児科, 准教授 (50316709)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 新生児仮死 / 神経後遺症 / 脳性麻痺 / グリコーゲン / 嫌気性解糖 / アストロサイト / 遺伝子多型 / グリコーゲン代謝 / 脳型ホスホリラーゼ / 低酸素性虚血性脳症 / 脳エネルギー代謝 / 脳性まひ / 痙性両麻痺 / 脳グリコーゲン / 脳エネルギー産生 |
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| Outline of Final Research Achievements |
In this study, brain glycogen phosphorylase gene（PYGB) polymorphism, which is an enzyme involved in the first step of anaerobic glycolysis, was investigated as a factor modifying the cerebral metabolism during the ecent on neonatal asphyxia. Subjects experienced similar degree of neonatal asphyxia including with typical development and neurological sequelae were used. As a result, in the poor prognostic group, there was a significant difference in gene polymorphisms in exons 12 and 14 of the PYGB gene. By using this gene polymorphism it is necessary to verify whether it can be established as a biomarker that can estimate the neurological prognosis of a child exposed to asphyxia in newborn and whether it can be an important evidence for early treatment and therapy .
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