A Study on Cerebral Protection Mechanism against Neonatal Asphyxia: Treatment strategy Based on Brain Glycogen Metabolism
| Project/Area Number |
25461652
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tokoha University (2014-2016)
Jichi Medical University (2013) |
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Principal Investigator |
SUGIE Hideo 常葉大学, 保健医療学部, 教授 (60119980)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUDA Tokiko 浜松医科大学, 小児科, 准教授 (10458268)
KONO Yumi 自治医科大学, 小児科, 教授 (50243390)
HIRASAWA Kyoko 東京女子医科大学, 小児科, 准教授 (50316709)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 新生児仮死 / 神経後遺症 / 脳性麻痺 / グリコーゲン / 嫌気性解糖 / アストロサイト / 遺伝子多型 / グリコーゲン代謝 / 脳型ホスホリラーゼ / 低酸素性虚血性脳症 / 脳エネルギー代謝 / 脳性まひ / 痙性両麻痺 / 脳グリコーゲン / 脳エネルギー産生 |
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| Outline of Final Research Achievements |
In this study, brain glycogen phosphorylase gene（PYGB) polymorphism, which is an enzyme involved in the first step of anaerobic glycolysis, was investigated as a factor modifying the cerebral metabolism during the ecent on neonatal asphyxia. Subjects experienced similar degree of neonatal asphyxia including with typical development and neurological sequelae were used. As a result, in the poor prognostic group, there was a significant difference in gene polymorphisms in exons 12 and 14 of the PYGB gene. By using this gene polymorphism it is necessary to verify whether it can be established as a biomarker that can estimate the neurological prognosis of a child exposed to asphyxia in newborn and whether it can be an important evidence for early treatment and therapy .
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Report
(5 results)
Research Products
(37 results)
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[Journal Article] Divergent clinical outcomes of alpha-glucosidase enzyme replacement therapy in two siblings with infantile-onset Pompe disease treated in the symptomatic or pre-symptomatic state.2016
Author(s)
Matsuoka T, Miwa Y, Tajika M, Sawada M, Fujimaki K, Soga T, Tomita H, Uemura S, Nishino I, Fukuda T, Sugie H, Kosuga M, Okuyama T, Umeda Y
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Journal Title
Mol Genet Metab Rep
Volume: 9
Pages: 98-105
DOI
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[Journal Article] Clinical, biochemical and molecular investigation of adult-onset glutaric acidemia type II: Characteristics in comparison with pediatric cases.2016
Author(s)
Yamada K, Kobayashi H, Bo R, Takahashi T, Purevsuren J, Hasegawa Y, Taketani T, Fukuda S, Ohkubo T, Yokota T, Watanabe M, Tsunemi T, Mizusawa H, Takuma H, Shioya A, Ishii A, Tamaoka A, Shigematsu Y, Sugie H, Yamaguchi S.
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Journal Title
Brain Dev.
Volume: 38
Issue: 3
Pages: 293-301
DOI
Related Report
Peer Reviewed
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[Journal Article] A hemizygous GYG2 mutation and Leigh syndrome: a possible link?2014
Author(s)
Imagawa E, Osaka H, Yamashita A, Shiina M, Takahashi E, Sugie H, Nakashima M, Tsurusaki Y, Saitsu H, Ogata K, Matsumoto N, Miyake N.
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Journal Title
Hum Genet.
Volume: 133(2
Issue: 2
Pages: 225-34
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 肝機能障害、腹部膨満を主訴に診断に至った糖原病IX型の1例2016
Author(s)
小貫 孝則(新潟市民病院 小児科), 田屋 光将, 佐藤 大祐, 川島 英志, 松井 亨, 阿部 裕樹, 上原 由美子, 渡辺 徹, 阿部 時也, 佐藤 誠一, 杉江 秀夫, 福田 冬季子
Organizer
第119回日本小児科学会学術集会
Place of Presentation
札幌
Year and Date
2016-05-13
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坂中 亜衣, 高島 美和, 深山 侑祐, 廣佐古 裕子, 本郷 涼子, 花田 浩和, 中富 明子, 伊達木 澄人, 本村 秀樹, 松本 正, 森内 浩幸, 福田 冬季子, 杉江 秀夫, 世羅 至子
Organizer
第１９回日本病態栄養学会年次学術集会
Place of Presentation
横浜
Year and Date
2016-01-09
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[Presentation] 当院における副腎白質ジストロフィー6例の臨床的検討2014
Author(s)
宮内彰彦1, 門田行史, 池田尚広, 川原勇太, 長嶋雅子, 小坂仁, 杉江秀夫, 森本哲, 渡辺浩史, 下泉秀夫, 下澤伸行, 山形崇倫
Organizer
第５６回日本小児神経学会学術集会
Place of Presentation
浜松市
Year and Date
2014-05-29 – 2014-05-31
Related Report
Invited
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