| Project/Area Number |
25461653
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOMATA Reiko 埼玉医科大学, 医学部, 助手 (50468378)
KAMEZAWA Hajime 埼玉医科大学, 医学部, 助手 (50646677)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 神経管閉鎖障害 / 二分脊椎 / 亜鉛イオン / 両生類 / 神経胚形成 / 発生 / 亜鉛 / 二分脊椎症 / カルシウムイオン / 脊柱管形成 / 無脳症 |
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| Outline of Final Research Achievements |
Neural tube defects (NTDs) are birth defects of the brain and spinal cord. NTDs are caused relatively at a high frequency in the newborn, and the symptoms are severe. The exact causes and mechanisms of NTDs are unclear. Many different factors, such as, genetics, environmental pollution, and nutrition (excess or deficiency of vitamin B and zinc ion) are likely to play a role. We analyzed the effects of excess zinc ions on neural tube formation of amphibian (newt) embryos in order to clarify the mechanism by which NTDs are caused. In this study, specific effects of zinc ions on the developing brain and spinal cord in amphibian embryos were demonstrated, and some mechanism of NTDs induced by zinc ions was revealed.
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