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Pharmacogenetics of abnormal glucose metabolism and weight gain induced by atypical antipsychotics

Research Project

Project/Area Number 25461725
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionNiigata University

Principal Investigator

Fukui Naoki  新潟大学, 医歯学系, 助教 (90535163)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords抗精神病薬 / 糖代謝異常 / 脂質代謝異常 / 体重増加 / 薬理遺伝学
Outline of Final Research Achievements

Meta-analysis of genome-wide association studies (GWAS) have detected several genetic markers related with glucose metabolism and obesity. We have examined relationships between these genetic markers and abnormal glucose metabolism and weight gain induced by atypical antipsychotics. Consequently, we found that, ⅰ) there may be different effects of the various antipsychotics on incretin secretion, ⅱ) the relationship between Trib1 gene and abnormal lipid metabolism, ⅲ) the relationship between GIPR gene and abnormal lipid metabolism.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 2013 Other

All Journal Article (7 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] 抗精神病薬の副作用と予測因子2016

    • Author(s)
      福井直樹
    • Journal Title

      精神科臨床Legato

      Volume: 2(1) Pages: 24-27

    • Related Report
      2015 Annual Research Report
  • [Journal Article] GIPR Gene Polymorphism and Weight Gain in Patients With Schizophrenia Treated With Olanzapine2015

    • Author(s)
      Ono S, Suzuki Y, Fukui N, Sawamura K, Sugai T, Watanabe J, Tsuneyama N, Someya T
    • Journal Title

      The Journal of Neuropsychiatry and Clinical Neurosciences

      Volume: 27(2) Issue: 2 Pages: 162-4

    • DOI

      10.1176/appi.neuropsych.13120389

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Improvement of dumping syndrome and oversecretion of glucose-dependent insulinotropic polypeptide following a switch from olanzapine to quetiapine in a patient with schizophrenia2015

    • Author(s)
      渡邉藍子
    • Journal Title

      Gen Hosp Psychiatry

      Volume: 37(4) Issue: 4 Pages: 372.e5-372.e6

    • DOI

      10.1016/j.genhosppsych.2015.03.012

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 統合失調症患者の突然死リスクと遺伝子研究2015

    • Author(s)
      福井直樹
    • Journal Title

      臨床精神薬理

      Volume: 18(1) Pages: 69-75

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Improvement of dumping syndrome and oversecretion of glucose-dependent insulinotropic polypeptide following a switch from olanzapine to quetiapine in a patient with schizophrenia.2015

    • Author(s)
      渡邉藍子
    • Journal Title

      General Hospital Psychiatry

      Volume: Epub ahead of print

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Low prevalence of metabolic syndrome and its prediction in Japanese inpatients with schizophrenia.2013

    • Author(s)
      Suzuki Y, Sugai T, Fukui N, Watanabe J, Ono S, Tsuneyama N, Saito M, Someya T.
    • Journal Title

      Hum Psychopharmacol.

      Volume: 28 Issue: 2 Pages: 188-91

    • DOI

      10.1002/hup.2295

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The prevalence of glucose intolerance in Japanese schizophrenic patients with a normal fasting glucose level.2013

    • Author(s)
      Ono S, Suzuki Y, Fukui N, Sugai T, Watanabe J, Tsuneyama N, Saito M, Someya T.
    • Journal Title

      J Clin Psychopharmacol.

      Volume: 33 Issue: 4 Pages: 525-7

    • DOI

      10.1097/jcp.0b013e3182905775

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Improvement of dumping syndrome following a switch from olanzapine to quetiapine in a patient with schizophrenia2015

    • Author(s)
      福井直樹
    • Organizer
      4th Congress of Asian College of Neuropsychopharmacology
    • Place of Presentation
      Taipei(中華民国)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗精神病薬内服中の統合失調症群におけるGIPR遺伝子と脂質プロファイルとの関連について2015

    • Author(s)
      福井直樹
    • Organizer
      第25回日本臨床精神神経薬理学会
    • Place of Presentation
      京王プラザホテル(東京都千代田区)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 統合失調症およびTrib1遺伝子が脂質プロファイルへ与える影響について2014

    • Author(s)
      福井直樹
    • Organizer
      第24回日本臨床精神神経薬理学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2014-11-20
    • Related Report
      2014 Research-status Report
  • [Presentation] シンポジウム1: 統合失調症の薬理ゲノム研究2014

    • Author(s)
      福井直樹
    • Organizer
      第24回日本臨床精神神経薬理学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2014-11-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] オランザピン内服時に認められたダンピング症候群および糖負荷時のインクレチン過剰分泌がクエチアピンへの置換後改善した胃切除既往歴のある統合失調症患者の一例

    • Author(s)
      佐々木藍子
    • Organizer
      第23回日本臨床精神神経薬理学会
    • Place of Presentation
      宜野湾
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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