Pharmacogenetics of abnormal glucose metabolism and weight gain induced by atypical antipsychotics

• Project/Area Number: 25461725
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Niigata University
• Principal Investigator: Fukui Naoki 新潟大学, 医歯学系, 助教 (90535163)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 抗精神病薬 / 糖代謝異常 / 脂質代謝異常 / 体重増加 / 薬理遺伝学

Outline of Final Research Achievements

Meta-analysis of genome-wide association studies (GWAS) have detected several genetic markers related with glucose metabolism and obesity. We have examined relationships between these genetic markers and abnormal glucose metabolism and weight gain induced by atypical antipsychotics. Consequently, we found that, ⅰ) there may be different effects of the various antipsychotics on incretin secretion, ⅱ) the relationship between Trib1 gene and abnormal lipid metabolism, ⅲ) the relationship between GIPR gene and abnormal lipid metabolism.

Research Products

• [Journal Article] 抗精神病薬の副作用と予測因子 (2016)
  • Author(s): 福井直樹
  • Journal Title: 精神科臨床Legato Volume: 2（１） Pages: 24-27
• [Journal Article] GIPR Gene Polymorphism and Weight Gain in Patients With Schizophrenia Treated With Olanzapine (2015)
  • Author(s): Ono S, Suzuki Y, Fukui N, Sawamura K, Sugai T, Watanabe J, Tsuneyama N, Someya T
  • Journal Title: The Journal of Neuropsychiatry and Clinical Neurosciences Volume: 27(2) Issue: 2 Pages: 162-4
  • DOI: 10.1176/appi.neuropsych.13120389
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Improvement of dumping syndrome and oversecretion of glucose-dependent insulinotropic polypeptide following a switch from olanzapine to quetiapine in a patient with schizophrenia (2015)
  • Author(s): 渡邉藍子
  • Journal Title: Gen Hosp Psychiatry Volume: 37(4) Issue: 4 Pages: 372.e5-372.e6
  • DOI: 10.1016/j.genhosppsych.2015.03.012
  • Peer Reviewed / Open Access
• [Journal Article] 統合失調症患者の突然死リスクと遺伝子研究 (2015)
  • Author(s): 福井直樹
  • Journal Title: 臨床精神薬理 Volume: 18(1) Pages: 69-75
• [Journal Article] Improvement of dumping syndrome and oversecretion of glucose-dependent insulinotropic polypeptide following a switch from olanzapine to quetiapine in a patient with schizophrenia. (2015)
  • Author(s): 渡邉藍子
  • Journal Title: General Hospital Psychiatry Volume: Epub ahead of print
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Low prevalence of metabolic syndrome and its prediction in Japanese inpatients with schizophrenia. (2013)
  • Author(s): Suzuki Y, Sugai T, Fukui N, Watanabe J, Ono S, Tsuneyama N, Saito M, Someya T.
  • Journal Title: Hum Psychopharmacol. Volume: 28 Issue: 2 Pages: 188-91
  • DOI: 10.1002/hup.2295
  • Peer Reviewed
• [Journal Article] The prevalence of glucose intolerance in Japanese schizophrenic patients with a normal fasting glucose level. (2013)
  • Author(s): Ono S, Suzuki Y, Fukui N, Sugai T, Watanabe J, Tsuneyama N, Saito M, Someya T.
  • Journal Title: J Clin Psychopharmacol. Volume: 33 Issue: 4 Pages: 525-7
  • DOI: 10.1097/jcp.0b013e3182905775
  • Peer Reviewed
• [Presentation] Improvement of dumping syndrome following a switch from olanzapine to quetiapine in a patient with schizophrenia (2015)
  • Author(s): 福井直樹
  • Organizer: 4th Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Taipei（中華民国）
  • Year and Date: 2015-11-20
  • Int'l Joint Research
• [Presentation] 抗精神病薬内服中の統合失調症群におけるGIPR遺伝子と脂質プロファイルとの関連について (2015)
  • Author(s): 福井直樹
  • Organizer: 第25回日本臨床精神神経薬理学会
  • Place of Presentation: 京王プラザホテル（東京都千代田区）
  • Year and Date: 2015-10-30
• [Presentation] 統合失調症およびTrib1遺伝子が脂質プロファイルへ与える影響について (2014)
  • Author(s): 福井直樹
  • Organizer: 第24回日本臨床精神神経薬理学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2014-11-20
• [Presentation] シンポジウム１: 統合失調症の薬理ゲノム研究 (2014)
  • Author(s): 福井直樹
  • Organizer: 第24回日本臨床精神神経薬理学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2014-11-20
  • Invited
• [Presentation] オランザピン内服時に認められたダンピング症候群および糖負荷時のインクレチン過剰分泌がクエチアピンへの置換後改善した胃切除既往歴のある統合失調症患者の一例
  • Author(s): 佐々木藍子
  • Organizer: 第23回日本臨床精神神経薬理学会
  • Place of Presentation: 宜野湾