| Project/Area Number |
25461740
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
Ozeki Yuji 獨協医科大学, 医学部, 准教授 (90303768)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 統合失調症 / L-セリン / D-セリン / ホスホセリンホスファターゼ / ホスホセリンアミノトランスフェラーゼ / ホスホグリセリン酸デヒドロゲナーゼ / グリシン |
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| Outline of Final Research Achievements |
The treatment for schizophrenia has improved, but there are some symptoms which do not improve entirely. The cause of illness remains being unexplained. If the etiology of schizophrenia is elucidated, a treatment and the prophylaxis of schizophrenia will progress. There are various hypotheses, but we hypothesized that the L-serine synthesis pathway might be related with a disease, so we investigated the L-serine synthesis pathway system in the patients. As a result, we found synthetic ability of the synthetases of L-serine increasing in the patients. In addition, we found that quantities of the mRNA expression of the enzymes which synthesize L-serine were decreased in the patients. However, as a whole, the association between such change and blood concentration of L-serine was not found. In future, we are going to investigate the relationship between L-serine synthesis pathway and the blood concentration of L-serine or amino acids related to L-serine.
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