The basic research of the change of mood by zinc deficiency and social isolation
| Project/Area Number |
25461753
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Fukui |
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Principal Investigator |
Omata Naoto 福井大学, 医学部附属病院, 講師 (30334832)
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| Co-Investigator(Kenkyū-buntansha) |
KIYONO Yasushi 福井大学, 高エネルギー医学研究センター, 教授 (50305603)
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| Research Collaborator |
MIZUNO Tomoyuki 福井大学, 医学部病態制御医学講座精神医学領域, 協力研究員
MARUOKA Nobuyuki 福井大学, 医学部病態制御医学講座精神医学領域, 協力研究員
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 亜鉛欠乏 / 社会的隔離 / うつ様状態 / 躁様状態 / ノルエピネフリン / 神経可塑性 / うつ / 不安 |
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| Outline of Final Research Achievements |
Zinc deficiency (ZD) or/and Social Isolation (SI) were loaded to rats. ZD or SI alone increased anxiety-related behavior and depression-like behavior, but the co-occurrence of ZD and SI decreased them. ZD or SI alone decreased the expression of NE transporter in the locus coeruleus and the expression of brain-derived neurotrophic factor in the hippocampus, and the co-occurrence of ZD and SI made these incidences more prominent. These findings suggest that ZD or SI alone induces depressive state, but the co-occurrence of ZD and SI induces manic state, and that the impairment of NE system and neuronal plasticity contribute to these behavioral changes.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population.2015
Author(s)
Miyagawa T, Toyoda H, Kanbayashi T, Imanishi A, Sagawa Y, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, Tokunaga K.
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Journal Title
Hum Genome Var.
Volume: 17(2)
Issue: 1
Pages: 15031-15031
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mania: Not the opposite of depression, but an extension? Neuronal plasticity and polarity.2013
Author(s)
Mizuno T, Omata N, Murata T, Mitsuya H, Maruoka N, Mita K, Kiyono Y, Okazawa H, Ikeda H, Wada Y.
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Journal Title
Medical Hypotheses
Volume: 81(2)
Issue: 2
Pages: 175-9
DOI
Related Report
Peer Reviewed
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