| Project/Area Number |
25461753
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Fukui |
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Principal Investigator |
Omata Naoto 福井大学, 医学部附属病院, 講師 (30334832)
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| Co-Investigator(Kenkyū-buntansha) |
KIYONO Yasushi 福井大学, 高エネルギー医学研究センター, 教授 (50305603)
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| Research Collaborator |
MIZUNO Tomoyuki 福井大学, 医学部病態制御医学講座精神医学領域, 協力研究員
MARUOKA Nobuyuki 福井大学, 医学部病態制御医学講座精神医学領域, 協力研究員
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 亜鉛欠乏 / 社会的隔離 / うつ様状態 / 躁様状態 / ノルエピネフリン / 神経可塑性 / うつ / 不安 |
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| Outline of Final Research Achievements |
Zinc deficiency (ZD) or/and Social Isolation (SI) were loaded to rats. ZD or SI alone increased anxiety-related behavior and depression-like behavior, but the co-occurrence of ZD and SI decreased them. ZD or SI alone decreased the expression of NE transporter in the locus coeruleus and the expression of brain-derived neurotrophic factor in the hippocampus, and the co-occurrence of ZD and SI made these incidences more prominent. These findings suggest that ZD or SI alone induces depressive state, but the co-occurrence of ZD and SI induces manic state, and that the impairment of NE system and neuronal plasticity contribute to these behavioral changes.
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