State markers of autism spectrum disorder: clinical application of eye tracking devices

• Project/Area Number: 25461758
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Tsuchiya Kenji 浜松医科大学, 子どものこころの発達研究センター, 准教授 (20362189)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Katsuaki 浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (00285040) ; MATSUZAKI Hideo 福井大学, 子どものこころの発達研究センター, 教授 (00334970)
• Co-Investigator(Renkei-kenkyūsha): MATSUMOTO Kaori 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (20447808) ; SHIMMURA Chie 浜松医科大学, 子どものこころの発達研究センター, 特任研究員 (30529467) ; TAKEI Noriyoshi 浜松医科大学, 子どものこころの発達研究センター, 教授 (80206937) ; KATAYAMA Taiichi 大阪大学, 大学院連合小児発達学研究科, 教授 (80333459) ; HONDA Maiko 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (40635629) ; NARUMIYA Makiko 浜松医科大学, 医学部附属病院, 臨床心理士 (20588769) ; HARAMAKI Tomoko 国立病院機構肥前精神医療センター, 臨床研究部, 研究員 (30601702) ; WAKUTA Manabu 大阪大学, 大学院連合小児発達学研究科, 講師 (20646210)
• Research Collaborator: KOSAKA Hirotaka 福井大学, 子どものこころの発達研究センター, 教授 ; FUJIOKA Toru 福井大学, 子どものこころの発達研究センター, 特任助教 ; SHUDO Katsuyuki (株)JVCケンウッド
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 自閉症スペクトラム / 注視点 / Gazefinder / 重症度 / 診断指標 / 重症度指標

Outline of Final Research Achievements

Eye gaze patterns of individuals with autism spectrum differ substantially from those outside the spectrum. Here we investigated whether severity of autism spectrum condition, using a novel device to measure autism spectrum traits, Gazefinder. With 158 individuals aged 2 to 16 years, we found that preferential looking on geometric patterns among individuals with autism spectrum disorder predict severity of the condition, if the individual is aged 5 years or older. We suggested that Gazefinder can be a useful tool to measure severity of autism spectrum.

Research Products

• [Journal Article] Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults. (2016)
  • Author(s): Fujioka T, Inohara K, Okamoto Y, Masuya Y, Ishitobi M, Saito DN, Jung M, Arai S, Matsumura Y, Fujisawa TX, Narita K, Suzuki K, Tsuchiya JK, Mori N, Katayama T, Sato M, Munesue T, Okazawa H, Tomoda A, Wada Y, Kosaka H.
  • Journal Title: Molecular Autism Volume: 7 Issue: 1 Pages: 19-19
  • DOI: 10.1186/s13229-016-0083-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gazefinder (Ka-o-TV) を用いた自閉スペクトラム症の早期診断指標の開発～1歳6カ月乳幼児健診における活用に向けて～ (2015)
  • Author(s): 1.土屋賢治，服巻智子，和久田学，新村千江，首藤勝行，大須賀優子，村田絵美，坂鏡子，中原竜治，浅野良輔，高貝就，鈴木勝昭，森則夫，黒木俊秀，片山泰一
  • Journal Title: 脳21 Volume: 18
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Broader autism phenotype as a risk factor for postpartum depression: Hamamatsu Birth Cohort (HBC) Study (2014)
  • Author(s): Asano R, Tsuchiya KJ, Takei N, Harada T, Kugizaki Y, Nakahara R, Nakayasu C, Okumura A, Suzuki Y, Takagai S, Mori N
  • Journal Title: Research in Autism Spectrum Disorders Volume: 8 Issue: 12 Pages: 1672-1678
  • DOI: 10.1016/j.rasd.2014.08.010
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Zinc finger protein 804A (ZNF804A) and verbal deficits in individuals with autism. (2014)
  • Author(s): Anitha A, Thanseem I, Nakamura K, Vasu MM, Yamada K, Ueki T, Iwayama Y, Toyota T, Tsuchiya KJ, Iwata Y, Suzuki K, Sugiyama T, Tsujii M, Yoshikawa T, Mori N.
  • Journal Title: J Psychiatry Neurosci Volume: 39 Issue: 5 Pages: 294-303
  • DOI: 10.1503/jpn.130126
  • Peer Reviewed / Open Access
• [Journal Article] Effectiveness of using the Modified Checklist for Autism in Toddlers in two-stage screening of autism spectrum disorder at the 18-month health check-up in Japan (2014)
  • Author(s): Kamio Y, Inada N, Koyama T, Inokuchi E, Tsuchiya K, Kuroda M
  • Journal Title: J Autism Dev Disord Volume: 44 Issue: 1 Pages: 193-202
  • DOI: 10.1007/s10803-013-1864-1
  • Peer Reviewed
• [Journal Article] A Comparison between Placental Gene Expression of 11βHydroxysteroid Dehydrogenases and Infantile Growth during at Ten Months. (2014)
  • Author(s): Muramatsu-Kato K, Itoh, H, Kohmura Y, Murakami H, Uchida T, Suzuki K, Sugihara K, Kanayama N
  • Journal Title: J Obstet Gynaecol Re. Volume: - Issue: 2 Pages: 465-472
  • DOI: 10.1111/jog.12200
  • Peer Reviewed
• [Presentation] 予防精神医学の可能性を探る (2014)
  • Author(s): 土屋賢治
  • Organizer: 第55回日本児童青年精神医学会総会
  • Place of Presentation: 浜松市
  • Year and Date: 2014-10-11 – 2014-10-23
  • Invited
• [Presentation] Placental weight and sleep onset among infants: Hamamatsu Birth Cohort (HBC) Study (2013)
  • Author(s): 1. Tsuchiya KJ, Asano R, Harada T, Kugizaki Y, Nakahara R, Nakayasu C, Okumura A, Suzuki Y, Takagai S, Itoh H, Takei N for HBC Study Team
  • Organizer: The 8th World Congress on Developmental Origins of Health and Disease
  • Place of Presentation: Singapore
• [Presentation] わが国におけるこころの発達コホート研究の将来展望
  • Author(s): 土屋賢治
  • Organizer: 第33回日本社会精神医学会
  • Place of Presentation: 東京
• [Presentation] 胎児～乳幼児期（小児含む）に着目した先制医療の精緻化：胎児期から出発する発達障害の理解と対応－浜松母と子の出生コホート研究
  • Author(s): 土屋賢治
  • Organizer: JST研究開発戦略センター（CRDS）科学技術未来戦略ワークショップ
  • Place of Presentation: 東京
• [Presentation] 特別セミナー：自閉症スペクトラム障害の研究と支援の最前線
  • Author(s): 土屋賢治
  • Organizer: 第110回日本小児精神神経学会
  • Place of Presentation: 名古屋
• [Patent(Industrial Property Rights)] 不注意の測定装置、システム、および方法 (2015)
  • Inventor(s): 森則夫、鈴木勝昭、土屋賢治、新村千江
  • Industrial Property Rights Holder: 森則夫、鈴木勝昭、土屋賢治、新村千江
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-09-30
• [Patent(Industrial Property Rights)] 不注意の測定装置、システム、方法、プログラム及び記憶媒体 (2014)
  • Inventor(s): 森則夫、鈴木勝昭、土屋賢治、新村千江
  • Industrial Property Rights Holder: 森則夫、鈴木勝昭、土屋賢治、新村千江
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-09-30