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The neural basis of depression based on the auditory change detection

Research Project

Project/Area Number 25461763
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionMie University

Principal Investigator

MOTOMURA Eishi  三重大学, 医学部附属病院, 講師 (10324534)

Co-Investigator(Kenkyū-buntansha) 前田 正幸  三重大学, 医学系研究科, 教授 (70219278)
乾 幸二  生理学研究所, システム脳科学研究領域, 准教授(兼任) (70262996)
Co-Investigator(Renkei-kenkyūsha) TANII Hisashi  三重大学, 医学系研究科, 准教授 (40346200)
SHIROYAMA Takashi  三重大学, 医学部附属病院, 講師 (00252354)
Research Collaborator OHOYAMA Keiko  
Project Period (FY) 2013-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsうつ病 / 誘発電位 / 誘発磁場 / 変化関連脳活動
Outline of Final Research Achievements

The change-related cerebral response, an auditory evoked potential measured by electroencephalography (EEG) or magnetoencephalography (MEG), is speculated to reflect the neural processing of sensory changes, which is essential for survival. Here we investigated the neural basis of depression by using the change-related cerebral response. We obtained the following findings. (1) The change-related response might be affected by personality traits, particularly anxiety- or depression-related traits. (2) The healthy subjects with Met carrier showed significantly higher amplitudes of the off-response compared to subjects with Val/Val in the BDNF polymorphisms. (3) The amplitude of the change-related response was significantly higher in the depressive patients compared to the healthy controls. These results suggest that high sensitivity of the change detection system might be a feature of predisposition to depression.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 2 results,  Open Access: 2 results) Presentation (4 results)

  • [Journal Article] Prepulse inhibition of the auditory off-response: A magnetoencephalographic study2017

    • Author(s)
      Motomura E, Inui K, Nishihara M, Tanahashi M, Kakigi R, Okada M
    • Journal Title

      Clin. EEG Neurosci

      Volume: 「-」

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Inhibition in the Human Auditory Cortex.2016

    • Author(s)
      Inui K, Nakagawa K, Nishihara M, Motomura E, Kakigi R.
    • Journal Title

      PLoS One

      Volume: 11(5) Issue: 5 Pages: e0155972-e0155972

    • DOI

      10.1371/journal.pone.0155972

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Auditory change-related cerebral responses and personality traits2016

    • Author(s)
      Tanahashi M., Motomura E., Inui K. et al.
    • Journal Title

      Neuroscience Research

      Volume: 103 Pages: 34-39

    • DOI

      10.1016/j.neures.2015.08.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Echoic memory: investigation of its temporal resolution by auditory offset cortical responses.2014

    • Author(s)
      Nishihara M, Inui K, Morita T, Kodaira M, Mochizuki H, Otsuru N, Motomura E, Ushida T, Kakigi R
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 8 Pages: e106553-e106553

    • DOI

      10.1371/journal.pone.0106553

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prepulse inhibition of change-related P50m no correlation with P50m gating.2013

    • Author(s)
      Koji Inui, Aki Tsuruhara, Kei Nakagawa, Makoto Nishihara, Minori Kodaira, Eishi Motomura, Ryusuke Kakigi
    • Journal Title

      SpringerPlus

      Volume: 2:588 Issue: 1 Pages: 1-9

    • DOI

      10.1186/2193-1801-2-588

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] .Effects of acute nicotine on prepulse inhibition of auditory change-related cortical responses.2013

    • Author(s)
      Kodaira M, Tsuruhara A, Motomura E, Tanii H, Inui K, Kakigi R.
    • Journal Title

      Behav Brain Res.

      Volume: 256 Pages: 27-35

    • DOI

      10.1016/j.bbr.2013.07.045

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 変化関連脳活動を用いて抑制系に迫る-新たな精神生理学的指標を目指して-2016

    • Author(s)
      元村英史
    • Organizer
      第14回三重神経生理フォーラム
    • Place of Presentation
      ホテルグリーンパーク津(三重県・津市)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Research-status Report
  • [Presentation] 感情障害における事象関連電位2016

    • Author(s)
      元村英史
    • Organizer
      第46回日本臨床神経生理学会
    • Place of Presentation
      ホテルハマツ(福島県・郡山市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 変化関連脳活動と人格特性―誘発電位とTemperament and Character Inventoryを用いて―2015

    • Author(s)
      棚橋めぐみ、元村英史、乾幸二ら
    • Organizer
      第111回日本精神神経学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル大阪 大阪府・大阪市
    • Year and Date
      2015-06-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 音圧変化と変化関連脳活動

    • Author(s)
      元村英史
    • Organizer
      第12回三重神経生理フォーラム
    • Place of Presentation
      津
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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