| Project/Area Number |
25461778
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nara Medical University |
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Principal Investigator |
Yoshino Hiroki 奈良県立医科大学, 医学部, 講師 (10347560)
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| Co-Investigator(Renkei-kenkyūsha) |
MAKINODAN Manabu 奈良県立医科大学, 医学部, 助教 (00510182)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 前頭葉 / 社会経験 / 興奮性 / 神経細胞 / 発達 / 前頭前野 / h-current / 錐体細胞 / 社会的経験 / 社会的隔離 / 興奮性後シナプス電流 / 膜興奮性 / 内側前頭前野 / 興奮性シナプス伝達 |
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| Outline of Final Research Achievements |
To elucidate how social experience during early childhood influence the development of prefrontal cortex, we compared the electrical activity of layer 5 pyramidal cell of medial prefrontal cortex in adulthood between isolate-housing mouse (be housed in isolation from postnatal 21 day to 35 day) and group-housing mouse. We found that the pyramidal cells of isolate-housing mouse has lower excitability than that of group-housing mouse, and the frequency of excitatory inputs into the pyramidal cell is lower in isolate-housing mouse than in group-housing mouse. Furthermore once we classified the pyramidal cells into two groups by the electrical character, we found that only one group of the pyramidal cells was influenced by social isolation.
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