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The research of social experience-dependent development of prefrontal excitatory neural circuit for psychiatric treatment

Research Project

Project/Area Number 25461778
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionNara Medical University

Principal Investigator

Yoshino Hiroki  奈良県立医科大学, 医学部, 講師 (10347560)

Co-Investigator(Renkei-kenkyūsha) MAKINODAN Manabu  奈良県立医科大学, 医学部, 助教 (00510182)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords前頭葉 / 社会経験 / 興奮性 / 神経細胞 / 発達 / 前頭前野 / h-current / 錐体細胞 / 社会的経験 / 社会的隔離 / 興奮性後シナプス電流 / 膜興奮性 / 内側前頭前野 / 興奮性シナプス伝達
Outline of Final Research Achievements

To elucidate how social experience during early childhood influence the development of prefrontal cortex, we compared the electrical activity of layer 5 pyramidal cell of medial prefrontal cortex in adulthood between isolate-housing mouse (be housed in isolation from postnatal 21 day to 35 day) and group-housing mouse. We found that the pyramidal cells of isolate-housing mouse has lower excitability than that of group-housing mouse, and the frequency of excitatory inputs into the pyramidal cell is lower in isolate-housing mouse than in group-housing mouse. Furthermore once we classified the pyramidal cells into two groups by the electrical character, we found that only one group of the pyramidal cells was influenced by social isolation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2015 2014

All Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Presentation] Social isolation during the critical period affects excitatory neuronal activity in mouse medial prefrontal cortex2015

    • Author(s)
      Yamamuro K, Yoshino H, Ogawa Y, Okamura Y, Nishihata Y, Saito Y, Kishimoto T
    • Organizer
      Society for neuroscience 45th annual meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Social isolation during the critical period and excitatory neuronal activity in mouse medial prefrontal cortex2015

    • Author(s)
      Yoshino H, Yamamuro K, Ogawa Y, Okamura K, Saito Y, Kishimoto T
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 臨界期の社会的隔離とマウス内側前頭前野皮質の興奮性神経活動2015

    • Author(s)
      芳野 浩樹、山室 和彦、小川 陽一、岡村 和哉、齋藤 康彦、岸本 年史
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28 – 2015-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 神経細胞の電気活動から精神疾患へ2015

    • Author(s)
      芳野 浩樹
    • Organizer
      第111回日本精神神経学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 臨界期の社会的孤立によるマウス内側前頭前野皮質の興奮性シナプス伝達の減弱2015

    • Author(s)
      山室 和彦、芳野 浩樹、小川 陽一、岡村 和哉、齋藤 康彦、岸本 年史
    • Organizer
      第92回日本生理学会大会 第120回日本解剖学会総会全国学術総会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Chronic social isolation reduces excitatory synaptic inputs in medial prefrontal cortex2014

    • Author(s)
      K. Yamamuro, H.Yoshino, Y. Ogawa, M. Makinodan, C.Gabriel, T. Kishimoto
    • Organizer
      44th Annual meeting of Society for neuroscience
    • Place of Presentation
      Washington DC USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 社会的孤立によるマウス内側前頭前皮質の興奮性シナプス伝達の減弱2014

    • Author(s)
      山室 和彦、芳野 浩樹、小川 陽一、牧之段 学、岸本 年史
    • Organizer
      第36回日本生物学的精神学会 第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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