Reoxygenation by radiation for dose escalated radiation therapy

• Project/Area Number: 25461797
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: OKAMOTO SHOZO 北海道大学, 大学病院, 助教 (20431364)
• Co-Investigator(Kenkyū-buntansha): YASUDA KOUITI 北海道大学, 大学院医学研究科, 特任助教 (00431362) ; SHIGA TOHRU 北海道大学, 大学院医学研究科, 准教授 (80374495)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: FMISO / 低酸素 / 放射線治療 / 再酸素化 / FMISO-PET

Outline of Final Research Achievements

We performed FMISO-PET (pre-therapeutic, inter-therapeutic, and post-therapeutic) studies for 20 patients in accordance with our protocol. Tumor hypoxia was observed in 19 patient on pre-therapeutic FMISO-PET.
FMISO uptake at the inter-therapeutic PET reduced than that at the pre-therapeutic PET in all patients. Tumor hypoxia disappeared at the inter-therapeutic PET in ten patients in these 19 patients. Seven patients showed disappearance of tumor hypoxia at the post-therapeutic PET. However, tumore hypoxia remained in 2 patients.
These results indicates that reoxygenation occurred in the early phase of radiation course by intensity-modulated radiation therapy.

Research Products

• [Presentation] 低酸素PETイメージングによるIMRTを用いた治療計画への応用 (2016)
  • Author(s): 岡本祥三
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-04-14
  • Invited
• [Presentation] Serial changes of tumor hypoxia in head and neck cancer treated with intensity-modulated radiation therapy (2014)
  • Author(s): 岡本祥三
  • Organizer: 第54回日本核医学会学術総会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2014-11-06 – 2014-11-08
  • Invited
• [Presentation] Serial changes of hypoxia and glucose metabolism in head and neck cancer after Intensity Modulated Radiation Therapy (2014)
  • Author(s): 岡本祥三
  • Organizer: Annual Congress of the European Association of Nuclear Medicine 2014
  • Place of Presentation: The Swedish Exhibition & Congress Centre(Gothenburg, Sweden)
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] 頭頚部癌に対するIMRTにおける腫瘍低酸素の経時的変化 (2014)
  • Author(s): 岡本祥三
  • Organizer: 第73回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] 頭頚部癌に対するIMRTによる (2014)
  • Author(s): 岡本祥三、志賀哲、安田耕一、他
  • Organizer: 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] Serial changes of hypoxia in head and neck cancer by fractionated radiotherapy with IMRT (2013)
  • Author(s): 岡本祥三、志賀哲、安田耕一、他
  • Organizer: 米国核医学会(Society of Nuclear Medicine and Molecular Imaging)
  • Place of Presentation: Vancouver Convention Centre(バンクーバー・カナダ)
• [Presentation] Noninvasive evaluation of tumor hypoxia with FMISO-PET (2013)
  • Author(s): 岡本祥三
  • Organizer: 日本癌学会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Invited
• [Presentation] 頭頚部癌に対するIMRTにおける腫瘍低酸素の経時的変化 (2013)
  • Author(s): 岡本祥三、志賀哲、安田耕一、他
  • Organizer: 日本核医学会総会
  • Place of Presentation: 福岡国際会議場(福岡市)