Reoxygenation by radiation for dose escalated radiation therapy
| Project/Area Number |
25461797
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
OKAMOTO SHOZO 北海道大学, 大学病院, 助教 (20431364)
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| Co-Investigator(Kenkyū-buntansha) |
YASUDA KOUITI 北海道大学, 大学院医学研究科, 特任助教 (00431362)
SHIGA TOHRU 北海道大学, 大学院医学研究科, 准教授 (80374495)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | FMISO / 低酸素 / 放射線治療 / 再酸素化 / FMISO-PET |
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| Outline of Final Research Achievements |
We performed FMISO-PET (pre-therapeutic, inter-therapeutic, and post-therapeutic) studies for 20 patients in accordance with our protocol. Tumor hypoxia was observed in 19 patient on pre-therapeutic FMISO-PET.
FMISO uptake at the inter-therapeutic PET reduced than that at the pre-therapeutic PET in all patients. Tumor hypoxia disappeared at the inter-therapeutic PET in ten patients in these 19 patients. Seven patients showed disappearance of tumor hypoxia at the post-therapeutic PET. However, tumore hypoxia remained in 2 patients.
These results indicates that reoxygenation occurred in the early phase of radiation course by intensity-modulated radiation therapy.
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Report
(4 results)
Research Products
(8 results)
