| Project/Area Number |
25461813
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Watanabe Shobu 滋賀医科大学, 医学部, 特任助教 (60570364)
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| Co-Investigator(Kenkyū-buntansha) |
NITTA Norihisa 滋賀医科大学, 医学部, 准教授 (40324587)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 酸化鉄ナノ粒子 / ドラッグデリバリーシステム / 酸化ナノ鉄粒子 / ドラッグ・デリバリー・システム |
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| Outline of Final Research Achievements |
We evaluated the anti-tumor effect using the newly developed negatively charged superparamagnetic ion-oxide (SPIO) nanoparticles created by changing the reaction time with cisplatin and the diameter of the particles.
In this study, negatively charged SPIO nanoparticle was combined with cisplatin well than conventional SPIO. Although the Iron concentration in the tumor tissue was higher in a small size of SPIO, Platinum concentration was lower in the tumor tissue. The reaction time did not have a clear influence on the antitumor effect. Further studies are necessary, such as conditions of the release of the drug, negatively charged SPIO nanoparticle can be expected to become an effective contrast agent also as drug delivery system.
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