| Project/Area Number |
25461816
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
NAKAMOTO Yuji 京都大学, 医学(系)研究科(研究院), 准教授 (20360844)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TEMMA Takashi 京都大学, 大学院薬学研究科, 助教 (90378787)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SANO Kohei 京都大学, 大学院医学研究科, 助教 (00546476)
MASUI Toshihiko 京都大学, 大学院医学研究科, 講師 (20452352)
YASODA Akihiro 京都大学, 大学院医学研究科, 講師 (50378642)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | がん / 画像診断 / ポジトロン断層撮像法 / 神経内分泌腫瘍 / オクトレオタイド / PET/CT / ガリウム-68 / ソマトスタチン受容体 / ソマトスタチン / イメージング / カルチノイド |
|---|
| Outline of Final Research Achievements |
Clinical efficacy of positron emission tomography using 68Ga-labeled octreotide has not been investigated in Japan so far. We applied DOTATOC-PET/CT in patients with neuroendocrine tumors. It provided useful information for making therapeutic strategies especially when recurrence had been suspected due to their higher hormone levels after resection of histologically-proven neuroendocrine tumors. On the other hand, it was indicated that information obtained by DOTATOC-PET/CT should be minimum simply when hormone levels were high without history of neuroendocrine tumors. In PET with fluorodeoxyglucose, dual-phase scanning sometimes yields significant information in clinical, but it was not helpful in DOTATOC-PET/CT because a sufficient tumor-to-background ratio can be obtained at 1-hr post-injection. As for the physiological uptake, pancreatic uncus was considered to be a pitfall in evaluating DOTATOC-PET images.
|
