| Project/Area Number |
25461831
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyushu University |
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Principal Investigator |
Nagao Michinobu 九州大学, 医学(系)研究科(研究院), 准教授 (60533081)
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| Co-Investigator(Kenkyū-buntansha) |
Kamitani Takeshi 九州大学, 病院, 助教 (20419534)
Yamamura Kenichiro 九州大学, 病院, 助教 (30532858)
Honda Hiroshi 九州大学, 医学研究院, 教授 (90145433)
Sakamoto Ichiro 九州大学, 医学研究院, 助教 (90616616)
松尾 芳雄 九州大学, 大学病院, 助教 (50419595)
米澤 政人 九州大学, 大学病院, その他 (80529834)
川波 哲 九州大学, 医学(系)研究科(研究院), 助教 (50330999)
山崎 誘三 九州大学, 大学病院, その他 (00643347)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | MRI / 成人先天性心疾患 / 心筋ストレイン / 心臓同期性障害 / 心不全 / 心臓MRI / タギングMRI / 右心不全 |
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| Outline of Final Research Achievements |
Right ventricular (RV) failure and ventricular dyssynchrony are strong determinants of prognosis in patients with adult congenital heart disease (ACHD). The aim was to investigate the relationship between interventricular dyssynchrony (IVD) using tagged MRI and RV dysfunction in ACHD. 62 ACHD patients underwent tagging MRI. Time curves of myocardial strains for RV and left ventricle (LV) were delivered from tagging images. Contraction delay between RV and LV was computed by cross-correlation analysis of the two strain time curves and was defined as IVD. IVD was greater for patients with RVEF <40% than for those with RVEF >40% and was greater for patients with RV systolic pressure >40mmHg than for those with RV systolic pressure <40mmHg. ROC analysis revealed optimal IVD thresholds for detecting patients with RVEF <40% with C-statistics of 0.76 and patients with RV systolic pressure >40mmHg with C-statistics of 0.81. IVD may offer an indicator for RV failure in ACHD.
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