Analyze of right ventricular strain and cardiac dyssynchrony cine-tagging MRI in adult congenital heart disease

• Project/Area Number: 25461831
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: Nagao Michinobu 九州大学, 医学(系)研究科(研究院), 准教授 (60533081)
• Co-Investigator(Kenkyū-buntansha): Kamitani Takeshi 九州大学, 病院, 助教 (20419534) ; Yamamura Kenichiro 九州大学, 病院, 助教 (30532858) ; Honda Hiroshi 九州大学, 医学研究院, 教授 (90145433) ; Sakamoto Ichiro 九州大学, 医学研究院, 助教 (90616616) ; 松尾 芳雄 九州大学, 大学病院, 助教 (50419595) ; 米澤 政人 九州大学, 大学病院, その他 (80529834) ; 川波 哲 九州大学, 医学(系)研究科(研究院), 助教 (50330999) ; 山崎 誘三 九州大学, 大学病院, その他 (00643347)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: MRI / 成人先天性心疾患 / 心筋ストレイン / 心臓同期性障害 / 心不全 / 心臓MRI / タギングMRI / 右心不全

Outline of Final Research Achievements

Right ventricular (RV) failure and ventricular dyssynchrony are strong determinants of prognosis in patients with adult congenital heart disease (ACHD). The aim was to investigate the relationship between interventricular dyssynchrony (IVD) using tagged MRI and RV dysfunction in ACHD. 62 ACHD patients underwent tagging MRI. Time curves of myocardial strains for RV and left ventricle (LV) were delivered from tagging images. Contraction delay between RV and LV was computed by cross-correlation analysis of the two strain time curves and was defined as IVD. IVD was greater for patients with RVEF <40% than for those with RVEF >40% and was greater for patients with RV systolic pressure >40mmHg than for those with RV systolic pressure <40mmHg. ROC analysis revealed optimal IVD thresholds for detecting patients with RVEF <40% with C-statistics of 0.76 and patients with RV systolic pressure >40mmHg with C-statistics of 0.81. IVD may offer an indicator for RV failure in ACHD.

Research Products

• [Journal Article] Quantification of coronary flow using dynamic angiography with320-detector row CT and motion coherence image processing:Detection of ischemia for intermediate coronary stenosis (2016)
  • Author(s): Nagao M, Yamasaki Y, Kamitani T, et al.
  • Journal Title: European Journal of Radiology Volume: 85 Issue: 5 Pages: 996-1003
  • DOI: 10.1016/j.ejrad.2016.02.027
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of ventricular dysfunction using semi-automatic longitudinal strain analysis of four-chamber cine MR imaging (2016)
  • Author(s): Kawakubo M, Nagao M, Kumazawa S, et al.
  • Journal Title: International Journal of Cardiovascular Imaging Volume: 32 Issue: 2 Pages: 283-289
  • DOI: 10.1007/s10554-015-0771-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Interventricular Dyssynchrony Using Tagging Magnetic Resonance Imaging Predicts Right Ventricular Dysfunction in Adult Congenital Heart Disease (2015)
  • Author(s): Nagao M, Yamasaki Y, Yonezawa M, et al.
  • Journal Title: Congenital Heart Disease Volume: 10 Pages: 271-280
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 1.Prediction of adverse cardiac events in dilated cardiomyopathy using cardiac T2* MRI and MIBG scintigraphy. (2015)
  • Author(s): Michinobu Nagao, Shingo Baba, Masato Yonezawa, Yuzo Yamasaki, Takeshi Kamitani, Takuro Isoda, Satoshi Kawanami, Yasuhiro Maruoka, Yoshiyuki Kitamura, Kohtaro Abe, Taiki Higo, Kenji Sunagawa, Hiroshi Honda
  • Journal Title: International Journal of Cardiovascular Imaging Volume: 31 Issue: 2 Pages: 399-407
  • DOI: 10.1007/s10554-014-0562-1
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clinical impact of left ventricular eccentricity index using cardiac MRI in assessment of right ventricular hemodynamics and myocardial fibrosis in congenital heart disease. (2015)
  • Author(s): Yamasaki Y, Nagao M, Kamitani T, Yamanouchi T, Kawanami S, Yamamura K, Sakamoto I, Yabuuchi H, Honda H
  • Journal Title: European Radiology Volume: 24 Issue: 10 Pages: 368-74
  • DOI: 10.1007/s00330-015-4199-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical Impact of Interventricular Dyssynchrony in Repaired Tetralogy of Fallot: Myocardial Strain Analysis Using Semi-automatic Tracking of Cine Magnetic Resonance Imaging (2015)
  • Author(s): Kawakubo M, Yamasaki Y, Nakamoto I, Yamamura K, Nagao M.
  • Journal Title: Journal of Adult Congenital Heart Disease Volume: 4 Pages: 69-73
  • Peer Reviewed
• [Journal Article] Interventricular dyssynchrony using tagging magnetic resonance imaging predicts right ventricular dysfunction in adult congenital heart disease. (2014)
  • Author(s): Michinobu Nagao, Yuzo Yamasaki, Masato Yonezawa, Yoshio Matsuo, Takeshi Kamitani, Kenichiro Yamamura, Ichiro Sakamoto, Kohtaro Abe, Satoshi Kawanami, Hiroshi Honda.
  • Journal Title: Congenital Heart Disease Volume: online Issue: 3 Pages: 1-10
  • DOI: 10.1111/chd.12217
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Geometrical characteristics of left ventricular dyssynchrony in advanced heart failure: myocardial strain analysis by tagged MRI. (2014)
  • Author(s): Michinobu Nagao, Yuzo Yamasaki, Masato Yonezawa, Takeshi Kamitani, Satoshi Kawanami, Yasushi Mukai, Taiki Higo, Hidetake Yabuuchi, Kenji Sunagawa, Hiroshi Honda.
  • Journal Title: International Heart Journal Volume: 55 Pages: 512-518
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Quantitative assessment of right ventricular function and pulmonary regurgitation in surgically repaired tetralogy of Fallot using 256-slice CT: comparison with 3-Tesla MRI. (2014)
  • Author(s): Yuzo Yamasaki, Michinobu Nagao, Kenichiro Yamamura, Masato Yonezawa, Yoshio Matsuo, Satoshi Kawanami, Takeshi Kamitani, Ko Higuchi, Ichiro Sakamoto, Yuichi Shiokawa, Hidetake Yabuuchi, Hiroshi Honda.
  • Journal Title: European Radiology Volume: 24 Issue: 12 Pages: 3289-3299
  • DOI: 10.1007/s00330-014-3344-1
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Quantification of myocardial iron deficiency in nonischemic heart failure by cardiac t2* magnetic resonance imaging. (2014)
  • Author(s): Nagao M, Matsuo Y, Kamitani T, Yonezawa M, Yamasaki Y, Kawanami S, Abe K, Mukai Y, Higo T, Yabuuchi H, Takemura A, Yoshiura T, Sunagawa K, Honda H.
  • Journal Title: Am J Cardiol. Volume: 113 Issue: 6 Pages: 1024-1030
  • DOI: 10.1016/j.amjcard.2013.11.061
  • Peer Reviewed
• [Presentation] Assessment of Flow Energy after Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension Using Phase-contrast MRI (2016)
  • Author(s): Michinobu Nagao
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] Quantification of Oxygen Consumption in Heart Failure Using BOLD Effect of T2-star Magnetic Resonance Imaging: Comparison with Cardiopulmonary Exercise Test (2016)
  • Author(s): Michinobu Nagao
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension: assessment of CT angiography, MRI, and perfusion scintigraphy (2016)
  • Author(s): Michinobu Nagao
  • Organizer: 1st Asia Oceania Workshop of Pulmonary Functional Imaging and 8th Japanese Society of Pulmonary Functional Imaging
  • Place of Presentation: Awajishima, Japan
  • Year and Date: 2016-01-29
  • Int'l Joint Research / Invited
• [Presentation] Quantification of coronary flow using dynamic angiography with 320-detector row CT and motion coherence image processing: Detection of ischemia for intermediate coronary stenosis (2015)
  • Author(s): Michinobu Nagao
  • Organizer: 10th Annual Scientific Meeting of the Society of Cardiovascular Computed Tomography
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2015-07-16
  • Int'l Joint Research
• [Presentation] Clinical impact of left ventricular eccentricity index using cardiac cine MRI for assessment of right ventricular hemodynamics in adult congenital heart disease (2015)
  • Author(s): Yuzo Yamasaki, Michinobu Nagao et al.
  • Organizer: ISMRM 2015 23th Annual Meeting
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Interventricular dyssynchrony using tagging magnetic resonance imaging predicts right ventricular dysfunction in adult congenital heart disease. (2015)
  • Author(s): Michinobu Nagao, Yuzo Yamasaki, Masato Yonezawa, Yoshio Matsuo, Takeshi Kamitani, Kenichiro Yamamura, Ichiro Sakamoto, Kohtaro Abe, Satoshi Kawanami, Hiroshi Honda
  • Organizer: 第17回日本成人先天性心疾患学会
  • Place of Presentation: 東京
  • Year and Date: 2015-01-16 – 2015-01-18
• [Presentation] Semi-automatic cardiac longitudinal strain analysis using four-chamber cine MR imaging: Correlation with left ventricular dysfunction (2014)
  • Author(s): Masateru Kawakubo, Michinobu Nagao, Seiji Kumazawa, Masato Yonezawa, Yuzo Yamasaki, Chishaki S Akiko, Yasuhiko Nakamura, Hiroshi Honda, Junji Morishita
  • Organizer: 100th RSNA 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] 成人先天性心疾患のCTとMRI (2014)
  • Author(s): 長尾充展
  • Organizer: 第11回成人先天性心疾患セミナー
  • Place of Presentation: 福岡
  • Year and Date: 2014-10-18
  • Invited
• [Presentation] Myocardial iron deficiency in non-ischemic heart failure: quantification by cardiac T2* magnetic resonance imaging. (2014)
  • Author(s): Michinobu Nagao, Masato Yonezawa, Takeshi Kamitani, Yuzo Yamasaki, Satoshi Kawanami, Youko Fujita, Kohtaro Abe, Taiki Higo, Kenji Sunagawa, Hiroshi Honda
  • Organizer: European Society of Cardiology Congress 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] MRIとCTによる心筋ストレイン (2014)
  • Author(s): 長尾充展
  • Organizer: 第73回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-04-10
  • Invited
• [Book] これだけは知っておきたい心臓・血管疾患の画像診断 (2016)
  • Author(s): 長尾充展
  • Total Pages: 388
  • Publisher: 学研メディカル秀潤社
• [Book] 知っておきたい循環器疾患のCT・MRI1 画像診断2015 7月号 (2015)
  • Author(s): 長尾充展
  • Total Pages: 135
  • Publisher: 学研メディカル秀潤社
• [Book] Structural heart disease/adult congenital heart diseaseのCT・MRI (2015)
  • Author(s): 長尾充展
  • Total Pages: 250
  • Publisher: メジカルビュー社
• [Book] 成人先天性心疾患パーフェクトガイド (2015)
  • Author(s): 長尾充展
  • Total Pages: 288
  • Publisher: 文光堂
• [Book] 臨床画像 4 増刊号 Cardiac imaging 2015 (2015)
  • Author(s): 長尾充展
  • Total Pages: 120
  • Publisher: メジカルビュー社
• [Book] 臨床放射線 (2015)
  • Author(s): 長尾充展, 米澤政人, 山崎誘三, 神谷武志, 藤田陽子, 山之内寅彦, 川波哲, 本田浩
  • Total Pages: 345
  • Publisher: 金原出版
• [Book] 臨床画像 (2015)
  • Author(s): 長尾充展, 米澤政人, 山崎誘三, 神谷武志, 山之内寅彦, 川波哲, 本田浩
  • Total Pages: 231
  • Publisher: メジカルビュー社
• [Book] 臨床放射線 (2014)
  • Author(s): 長尾充展, 馬場真吾, 米澤政人, 山崎誘三, 神谷武志, 川波哲, 磯田拓郎, 丸岡保博, 北村宣之, 松尾芳雄, 本田浩
  • Total Pages: 1910
  • Publisher: 金原出版