Heterogeneity of sympathetic nerve pre-synaptic function in the left ventricular wall in patients with dilated cardiomyopathy
Project/Area Number |
25461840
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Nagoya City University |
Principal Investigator |
Ohte Nobuyuki 名古屋市立大学, 医学(系)研究科(研究院), 教授 (10185332)
|
Co-Investigator(Kenkyū-buntansha) |
Nakagawa Motoo 名古屋市立大学, 医学研究科, 講師 (60590982)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 心不全 / PET / 心筋血流 / 心臓交感神経 / ammonia / hydroxyephedrine / ammmonia / 交感神経 / 血流 / 拡張型心筋症 / PET |
Outline of Final Research Achievements |
N-13 ammonia positron emission tomography (PET) for quantitative myocardial blood flow (MBF) measurement and C-11 hydroxyephedrine (HED) PET for quantitative sympathetic nerve pre-synaptic function evaluation were performed in 15 patients with dilated cardiomyopathy (DCM) and in 15 healthy volunteers. Both MBF and HED-RI of the whole left ventricle were significantly reduced in patients with DCM than in healthy volunteers. Heterogeneities of MBF and HED-RI among the segmental left ventricular walls were significantly greater in the DCM patients than in the healthy volunteers. Such heterogeneities of MBF and HED-RI as well as the reduction of both is related to the pathophysiology of heart failure in patients with DCM.
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Report
(4 results)
Research Products
(4 results)