Heterogeneity of sympathetic nerve pre-synaptic function in the left ventricular wall in patients with dilated cardiomyopathy

• Project/Area Number: 25461840
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagoya City University
• Principal Investigator: Ohte Nobuyuki 名古屋市立大学, 医学(系)研究科(研究院), 教授 (10185332)
• Co-Investigator(Kenkyū-buntansha): Nakagawa Motoo 名古屋市立大学, 医学研究科, 講師 (60590982)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 心不全 / PET / 心筋血流 / 心臓交感神経 / ammonia / hydroxyephedrine / ammmonia / 交感神経 / 血流 / 拡張型心筋症 / ＰＥＴ

Outline of Final Research Achievements

N-13 ammonia positron emission tomography (PET) for quantitative myocardial blood flow (MBF) measurement and C-11 hydroxyephedrine (HED) PET for quantitative sympathetic nerve pre-synaptic function evaluation were performed in 15 patients with dilated cardiomyopathy (DCM) and in 15 healthy volunteers. Both MBF and HED-RI of the whole left ventricle were significantly reduced in patients with DCM than in healthy volunteers. Heterogeneities of MBF and HED-RI among the segmental left ventricular walls were significantly greater in the DCM patients than in the healthy volunteers. Such heterogeneities of MBF and HED-RI as well as the reduction of both is related to the pathophysiology of heart failure in patients with DCM.

Research Products

• [Presentation] Heterogeneity of Sympathetic Nervous Funtion in Left Ventricle is an Important Factor for Left Ventricular Dysfunction in Dilated Cardiomyopathy (2015)
  • Author(s): Shohei Kikuchi
  • Organizer: 第79回日本循環器学会
  • Place of Presentation: 大阪国際会議場（大阪府、大阪市）
  • Year and Date: 2015-04-24 – 2015-04-29
• [Presentation] Heterogeneity of Sympathetic Nerve Function in Left Ventricle is an Important Factor for Left Ventricular Dysfunction in Dilated Cardiomyopathy (2015)
  • Author(s): Shohei Kikuchi
  • Organizer: 第79回日本循環器学会
  • Place of Presentation: 大阪国際会議場（大阪府、大阪市）
  • Year and Date: 2015-04-24
• [Presentation] Heterogeneity of Sympathetic Nervous Density in the Left Ventricular Wall in Dilated Cardiomyopathy (2014)
  • Author(s): Shohei Kikuchi
  • Organizer: American Heart Association 2014
  • Place of Presentation: Chicago (U.S.A)
  • Year and Date: 2014-11-16 – 2014-11-19
• [Presentation] Presynaptic Sympathetic Nervous Function in Non-ischemic Cardiomyopathy Using Positron Emission Tomography with Carbon-11 Hydroxyephedrine (2014)
  • Author(s): 菊池祥平、 後藤利彦、山本浩司、若見和明、福田英克、成田ひとみ、飯田昭彦、大手信之
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京）