Differentiated imaging of microstructures in brain tumors using phase difference enhanced imaging (PADRE) by high magnetic field MRI system

• Project/Area Number: 25461843
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka City University
• Principal Investigator: SAKAMOTO Shinichi 大阪市立大学, 大学院医学研究科, 講師 (40464648)
• Co-Investigator(Kenkyū-buntansha): 米田 哲也 熊本大学, 大学院生命科学研究部(保), 准教授 (20305022) ; 三木 幸雄 大阪市立大学, 大学院医学研究科, 教授 (80303824)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: PADRE / 位相画像 / 脳腫瘍 / 石灰化

Outline of Final Research Achievements

Brain tumors influence various microstructures of the brain, which are sometimes essential of biological feature; and these microstructures have a possibility to be imaged separately using phase difference enhanced imaging (PADRE) technique.
In the present study, vascular-enhanced images and myelin-enhanced images were obtained with PADRE technique. In two groups of 11 cases of metastatic brain tumors（age 64.3±13.9）and 31 cases of glioma（WHO grading 2-4）（age 49.6±21.9）, vessels and myelin fibers of cerebral white matter including optic radiations were visually analyzed using the four grade of imaging findings （1: poor; 2: fair; 3:　moderate; 4: good）. Delineations of vascular components showed no statistically significant differences between the two groups of metastatic brain tumor and glioma（p=0.56）, while these of optic radiations showed statistically significant（p=0.04）.